Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-[alpha]

Vaccination with tumor-specific antigens is one of several attempted therapies seeking to harness the immune system, but -- unfortunately -- this strategy has been unsuccessful, possibly because of the immunosuppressive properties of the tumor microenvironment. Kraman et al. (p. 827; see the Perspec...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2010-11, Vol.330 (6005), p.827-830
Hauptverfasser:	Kraman, Matthew, Bambrough, Paul J, Arnold, James N, Roberts, Edward W, Magiera, Lukasz, Jones, James O, Gopinathan, Aarthi, Tuveson, David A, Fearon, Douglas T
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Activation Cancer Cancer therapies Depletion Fibroblasts Human Immunity Immunotherapy Transgenic Tumors Vaccines
Online-Zugang:	Volltext
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