A Yeast Toxic Mutant of HET-s^sub (218-289)^ Prion Displays Alternative Intermediates of Amyloidogenesis

Amyloids are thought to be involved in various types of neurodegenerative disorders. Several kinds of intermediates, differing in morphology, size, and toxicity, have been identified in the multistep amyloidogenesis process. However, the mechanisms explaining amyloid toxicity remain unclear. We prev...

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Veröffentlicht in:	Biophysical journal 2010-08, Vol.99 (4), p.1239-1246
Hauptverfasser:	Berthelot, Karine, Lecomte, Sophie, Géan, Julie, Immel, Françoise, Cullin, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Mutation Neurodegeneration Neurotoxicity Prions Proteins Yeast
Online-Zugang:	Volltext
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