Fluoride Excess and Periostitis in Transplant Patients Receiving Long-Term Voriconazole Therapy

Background. We describe a heart transplant patient with painful periostitis and exostoses who was receiving long-term therapy with voriconazole, which is a fluoride-containing medication. Elevated plasma and bone fluoride levels were identified. Discontinuation of voriconazole therapy led to improve...

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Veröffentlicht in:	Clinical infectious diseases 2011-03, Vol.52 (5), p.604-611
Hauptverfasser:	Wermers, Robert A., Cooper, Kay, Razonable, Raymund R., Deziel, Paul J., Whitford, Gary M., Kremers, Walter K., Moyer, Thomas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alkaline Phosphatase - blood Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - adverse effects Antifungal Agents - therapeutic use ARTICLES AND COMMENTARIES Biological and medical sciences Blood plasma Bones Control groups Diseases of the osteoarticular system Drug therapy Exostoses Exostoses - chemically induced Female Fluorides Fluorides - blood Fluorosis Heart Heart Transplantation - adverse effects Humans Infectious diseases Male Measurement Medical sciences Medications Middle Aged Osteoporosis. Osteomalacia. Paget disease Periostitis Periostitis - chemically induced Pharmacology. Drug treatments Phosphatases Plasma Plasma - chemistry Pyrimidines - adverse effects Pyrimidines - therapeutic use Transplantation Transplants & implants Triazoles - adverse effects Triazoles - therapeutic use Voriconazole Water fluoridation
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