The relationship between serum thyrotropin and components of metabolic syndrome
To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyro...
Gespeichert in:
| Veröffentlicht in: | ENDOCRINE JOURNAL 2011, Vol.58(1), pp.23-30 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 30 |
|---|---|
| container_issue | 1 |
| container_start_page | 23 |
| container_title | ENDOCRINE JOURNAL |
| container_volume | 58 |
| creator | Lai, Yaxin Wang, Jiani Jiang, Fengwei Wang, Beibei Chen, Yanyan Li, Mengchun Liu, He Li, Chenyan Xue, Haibo Li, Ningna Yu, Jiashu Shi, Liangfeng Bai, Xue Hou, Xin Zhu, Lin Lu, Li Wang, Sen Xing, Qian Teng, Xiaochun Teng, Weiping Shan, Zhongyan |
| description | To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyrotropin (TSH), fasting plasma glucose (FPG), OGTT 2h PG, fasting insulin (FINS), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C). Serum TSH in metabolic syndrome group was higher than that in the non-metabolic syndrome group (2.54 mIU/L vs. 2.22 mIU/L, p‹0.05). TG level increased significantly in subclinical hypothyroid group compared with euthyroid subjects (1.73±0.12 mmol/L vs. 1.47±0.03 mmol/L, p‹0.05), and HDL-C decreased significantly in patients with subclinical hypothyroidism compared with euthyroid subjects (1.26±0.27 mmol/L vs. 1.33±0.27 mmol/L, p‹0.05). The prevalence of hypertension was higher in the subclinical hypothyroid group than that in euthyroid group (42.86% vs. 33.2%, p‹0.05). The serum TSH within the reference range was positively related with the prevalence of overweight/obesity. Slight increase in serum TSH maybe a risk factor for metabolic syndrome. |
| doi_str_mv | 10.1507/endocrj.K10E-272 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_849433786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>849433786</sourcerecordid><originalsourceid>FETCH-LOGICAL-c704t-e2902faf42681f1859ddfa5d392252427a2800602695d246f1a5cd7712f4fb333</originalsourceid><addsrcrecordid>eNpFkD1v3DAMhoWgRXJNs3cqvHVySn3Z8lgESVskQJZ0FnQylfPBlhxJRnH_Prrc5TKQHPjwJfkS8o3CNZXQ_kTfBxu31_cUbmvWsjOyolyoWkgBn8gKOqpq1cnugnxJaQvAuRT8nFwwSrmUFFbk8WmDVcTR5CH4tBnmao35P6KvEsZlqvJmF0OOYR58ZXxf2TDNwaPPqQqumjCbdRgHW6Wd72OY8Cv57MyY8OpYL8m_u9unmz_1w-Pvvze_Hmrbgsg1sg6YM06wRlFHlez63hnZ844xyQRrDVMADbCmkz0TjaNG2r5tKXPCrTnnl-THQXeO4WXBlPU0JIvjaDyGJWklOsF5q5pCwoG0MaQU0ek5DpOJO01B713URxf13kVdXCwj34_iy3rC_jTwblsB7g5A6Q7WjMGPg0e9DUv05WttX5o3Uc2AUg0gFbyVEoyXxIGy8pr4ENqmbJ7xtMnEPNgRT6dJpek-vZ94AuzGxELxV4LEnys</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>849433786</pqid></control><display><type>article</type><title>The relationship between serum thyrotropin and components of metabolic syndrome</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Lai, Yaxin ; Wang, Jiani ; Jiang, Fengwei ; Wang, Beibei ; Chen, Yanyan ; Li, Mengchun ; Liu, He ; Li, Chenyan ; Xue, Haibo ; Li, Ningna ; Yu, Jiashu ; Shi, Liangfeng ; Bai, Xue ; Hou, Xin ; Zhu, Lin ; Lu, Li ; Wang, Sen ; Xing, Qian ; Teng, Xiaochun ; Teng, Weiping ; Shan, Zhongyan</creator><creatorcontrib>Lai, Yaxin ; Wang, Jiani ; Jiang, Fengwei ; Wang, Beibei ; Chen, Yanyan ; Li, Mengchun ; Liu, He ; Li, Chenyan ; Xue, Haibo ; Li, Ningna ; Yu, Jiashu ; Shi, Liangfeng ; Bai, Xue ; Hou, Xin ; Zhu, Lin ; Lu, Li ; Wang, Sen ; Xing, Qian ; Teng, Xiaochun ; Teng, Weiping ; Shan, Zhongyan ; Department of Endocrinology and Metabolism ; The Liaoning Provincial Key Laboratory of Endocrine Diseases ; The First Hospital of China Medical University ; The Endocrine Institute of China Medical University</creatorcontrib><description>To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyrotropin (TSH), fasting plasma glucose (FPG), OGTT 2h PG, fasting insulin (FINS), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C). Serum TSH in metabolic syndrome group was higher than that in the non-metabolic syndrome group (2.54 mIU/L vs. 2.22 mIU/L, p‹0.05). TG level increased significantly in subclinical hypothyroid group compared with euthyroid subjects (1.73±0.12 mmol/L vs. 1.47±0.03 mmol/L, p‹0.05), and HDL-C decreased significantly in patients with subclinical hypothyroidism compared with euthyroid subjects (1.26±0.27 mmol/L vs. 1.33±0.27 mmol/L, p‹0.05). The prevalence of hypertension was higher in the subclinical hypothyroid group than that in euthyroid group (42.86% vs. 33.2%, p‹0.05). The serum TSH within the reference range was positively related with the prevalence of overweight/obesity. Slight increase in serum TSH maybe a risk factor for metabolic syndrome.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.K10E-272</identifier><identifier>PMID: 21135510</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Glucose - metabolism ; China - epidemiology ; Cholesterol, HDL - blood ; Female ; Glucose Tolerance Test ; Humans ; Hypertension - epidemiology ; Hyperthyroidism - diagnosis ; Hypothyroidism - diagnosis ; Insulin - blood ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - epidemiology ; Middle Aged ; Obesity - epidemiology ; Overweight ; Prevalence ; Subclinical hyperthyroidism ; Subclinical hypothyroidism ; Thyrotropin ; Thyrotropin - blood ; Triglycerides - blood</subject><ispartof>Endocrine Journal, 2011, Vol.58(1), pp.23-30</ispartof><rights>The Japan Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c704t-e2902faf42681f1859ddfa5d392252427a2800602695d246f1a5cd7712f4fb333</citedby><cites>FETCH-LOGICAL-c704t-e2902faf42681f1859ddfa5d392252427a2800602695d246f1a5cd7712f4fb333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21135510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Yaxin</creatorcontrib><creatorcontrib>Wang, Jiani</creatorcontrib><creatorcontrib>Jiang, Fengwei</creatorcontrib><creatorcontrib>Wang, Beibei</creatorcontrib><creatorcontrib>Chen, Yanyan</creatorcontrib><creatorcontrib>Li, Mengchun</creatorcontrib><creatorcontrib>Liu, He</creatorcontrib><creatorcontrib>Li, Chenyan</creatorcontrib><creatorcontrib>Xue, Haibo</creatorcontrib><creatorcontrib>Li, Ningna</creatorcontrib><creatorcontrib>Yu, Jiashu</creatorcontrib><creatorcontrib>Shi, Liangfeng</creatorcontrib><creatorcontrib>Bai, Xue</creatorcontrib><creatorcontrib>Hou, Xin</creatorcontrib><creatorcontrib>Zhu, Lin</creatorcontrib><creatorcontrib>Lu, Li</creatorcontrib><creatorcontrib>Wang, Sen</creatorcontrib><creatorcontrib>Xing, Qian</creatorcontrib><creatorcontrib>Teng, Xiaochun</creatorcontrib><creatorcontrib>Teng, Weiping</creatorcontrib><creatorcontrib>Shan, Zhongyan</creatorcontrib><creatorcontrib>Department of Endocrinology and Metabolism</creatorcontrib><creatorcontrib>The Liaoning Provincial Key Laboratory of Endocrine Diseases</creatorcontrib><creatorcontrib>The First Hospital of China Medical University</creatorcontrib><creatorcontrib>The Endocrine Institute of China Medical University</creatorcontrib><title>The relationship between serum thyrotropin and components of metabolic syndrome</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyrotropin (TSH), fasting plasma glucose (FPG), OGTT 2h PG, fasting insulin (FINS), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C). Serum TSH in metabolic syndrome group was higher than that in the non-metabolic syndrome group (2.54 mIU/L vs. 2.22 mIU/L, p‹0.05). TG level increased significantly in subclinical hypothyroid group compared with euthyroid subjects (1.73±0.12 mmol/L vs. 1.47±0.03 mmol/L, p‹0.05), and HDL-C decreased significantly in patients with subclinical hypothyroidism compared with euthyroid subjects (1.26±0.27 mmol/L vs. 1.33±0.27 mmol/L, p‹0.05). The prevalence of hypertension was higher in the subclinical hypothyroid group than that in euthyroid group (42.86% vs. 33.2%, p‹0.05). The serum TSH within the reference range was positively related with the prevalence of overweight/obesity. Slight increase in serum TSH maybe a risk factor for metabolic syndrome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Glucose - metabolism</subject><subject>China - epidemiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Hyperthyroidism - diagnosis</subject><subject>Hypothyroidism - diagnosis</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Obesity - epidemiology</subject><subject>Overweight</subject><subject>Prevalence</subject><subject>Subclinical hyperthyroidism</subject><subject>Subclinical hypothyroidism</subject><subject>Thyrotropin</subject><subject>Thyrotropin - blood</subject><subject>Triglycerides - blood</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1v3DAMhoWgRXJNs3cqvHVySn3Z8lgESVskQJZ0FnQylfPBlhxJRnH_Prrc5TKQHPjwJfkS8o3CNZXQ_kTfBxu31_cUbmvWsjOyolyoWkgBn8gKOqpq1cnugnxJaQvAuRT8nFwwSrmUFFbk8WmDVcTR5CH4tBnmao35P6KvEsZlqvJmF0OOYR58ZXxf2TDNwaPPqQqumjCbdRgHW6Wd72OY8Cv57MyY8OpYL8m_u9unmz_1w-Pvvze_Hmrbgsg1sg6YM06wRlFHlez63hnZ844xyQRrDVMADbCmkz0TjaNG2r5tKXPCrTnnl-THQXeO4WXBlPU0JIvjaDyGJWklOsF5q5pCwoG0MaQU0ek5DpOJO01B713URxf13kVdXCwj34_iy3rC_jTwblsB7g5A6Q7WjMGPg0e9DUv05WttX5o3Uc2AUg0gFbyVEoyXxIGy8pr4ENqmbJ7xtMnEPNgRT6dJpek-vZ94AuzGxELxV4LEnys</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Lai, Yaxin</creator><creator>Wang, Jiani</creator><creator>Jiang, Fengwei</creator><creator>Wang, Beibei</creator><creator>Chen, Yanyan</creator><creator>Li, Mengchun</creator><creator>Liu, He</creator><creator>Li, Chenyan</creator><creator>Xue, Haibo</creator><creator>Li, Ningna</creator><creator>Yu, Jiashu</creator><creator>Shi, Liangfeng</creator><creator>Bai, Xue</creator><creator>Hou, Xin</creator><creator>Zhu, Lin</creator><creator>Lu, Li</creator><creator>Wang, Sen</creator><creator>Xing, Qian</creator><creator>Teng, Xiaochun</creator><creator>Teng, Weiping</creator><creator>Shan, Zhongyan</creator><general>The Japan Endocrine Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>The relationship between serum thyrotropin and components of metabolic syndrome</title><author>Lai, Yaxin ; Wang, Jiani ; Jiang, Fengwei ; Wang, Beibei ; Chen, Yanyan ; Li, Mengchun ; Liu, He ; Li, Chenyan ; Xue, Haibo ; Li, Ningna ; Yu, Jiashu ; Shi, Liangfeng ; Bai, Xue ; Hou, Xin ; Zhu, Lin ; Lu, Li ; Wang, Sen ; Xing, Qian ; Teng, Xiaochun ; Teng, Weiping ; Shan, Zhongyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c704t-e2902faf42681f1859ddfa5d392252427a2800602695d246f1a5cd7712f4fb333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Glucose - metabolism</topic><topic>China - epidemiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Hyperthyroidism - diagnosis</topic><topic>Hypothyroidism - diagnosis</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Obesity - epidemiology</topic><topic>Overweight</topic><topic>Prevalence</topic><topic>Subclinical hyperthyroidism</topic><topic>Subclinical hypothyroidism</topic><topic>Thyrotropin</topic><topic>Thyrotropin - blood</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Yaxin</creatorcontrib><creatorcontrib>Wang, Jiani</creatorcontrib><creatorcontrib>Jiang, Fengwei</creatorcontrib><creatorcontrib>Wang, Beibei</creatorcontrib><creatorcontrib>Chen, Yanyan</creatorcontrib><creatorcontrib>Li, Mengchun</creatorcontrib><creatorcontrib>Liu, He</creatorcontrib><creatorcontrib>Li, Chenyan</creatorcontrib><creatorcontrib>Xue, Haibo</creatorcontrib><creatorcontrib>Li, Ningna</creatorcontrib><creatorcontrib>Yu, Jiashu</creatorcontrib><creatorcontrib>Shi, Liangfeng</creatorcontrib><creatorcontrib>Bai, Xue</creatorcontrib><creatorcontrib>Hou, Xin</creatorcontrib><creatorcontrib>Zhu, Lin</creatorcontrib><creatorcontrib>Lu, Li</creatorcontrib><creatorcontrib>Wang, Sen</creatorcontrib><creatorcontrib>Xing, Qian</creatorcontrib><creatorcontrib>Teng, Xiaochun</creatorcontrib><creatorcontrib>Teng, Weiping</creatorcontrib><creatorcontrib>Shan, Zhongyan</creatorcontrib><creatorcontrib>Department of Endocrinology and Metabolism</creatorcontrib><creatorcontrib>The Liaoning Provincial Key Laboratory of Endocrine Diseases</creatorcontrib><creatorcontrib>The First Hospital of China Medical University</creatorcontrib><creatorcontrib>The Endocrine Institute of China Medical University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Yaxin</au><au>Wang, Jiani</au><au>Jiang, Fengwei</au><au>Wang, Beibei</au><au>Chen, Yanyan</au><au>Li, Mengchun</au><au>Liu, He</au><au>Li, Chenyan</au><au>Xue, Haibo</au><au>Li, Ningna</au><au>Yu, Jiashu</au><au>Shi, Liangfeng</au><au>Bai, Xue</au><au>Hou, Xin</au><au>Zhu, Lin</au><au>Lu, Li</au><au>Wang, Sen</au><au>Xing, Qian</au><au>Teng, Xiaochun</au><au>Teng, Weiping</au><au>Shan, Zhongyan</au><aucorp>Department of Endocrinology and Metabolism</aucorp><aucorp>The Liaoning Provincial Key Laboratory of Endocrine Diseases</aucorp><aucorp>The First Hospital of China Medical University</aucorp><aucorp>The Endocrine Institute of China Medical University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between serum thyrotropin and components of metabolic syndrome</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>58</volume><issue>1</issue><spage>23</spage><epage>30</epage><pages>23-30</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyrotropin (TSH), fasting plasma glucose (FPG), OGTT 2h PG, fasting insulin (FINS), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C). Serum TSH in metabolic syndrome group was higher than that in the non-metabolic syndrome group (2.54 mIU/L vs. 2.22 mIU/L, p‹0.05). TG level increased significantly in subclinical hypothyroid group compared with euthyroid subjects (1.73±0.12 mmol/L vs. 1.47±0.03 mmol/L, p‹0.05), and HDL-C decreased significantly in patients with subclinical hypothyroidism compared with euthyroid subjects (1.26±0.27 mmol/L vs. 1.33±0.27 mmol/L, p‹0.05). The prevalence of hypertension was higher in the subclinical hypothyroid group than that in euthyroid group (42.86% vs. 33.2%, p‹0.05). The serum TSH within the reference range was positively related with the prevalence of overweight/obesity. Slight increase in serum TSH maybe a risk factor for metabolic syndrome.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>21135510</pmid><doi>10.1507/endocrj.K10E-272</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-8959 |
| ispartof | Endocrine Journal, 2011, Vol.58(1), pp.23-30 |
| issn | 0918-8959 1348-4540 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_849433786 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Blood Glucose - metabolism China - epidemiology Cholesterol, HDL - blood Female Glucose Tolerance Test Humans Hypertension - epidemiology Hyperthyroidism - diagnosis Hypothyroidism - diagnosis Insulin - blood Male Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Middle Aged Obesity - epidemiology Overweight Prevalence Subclinical hyperthyroidism Subclinical hypothyroidism Thyrotropin Thyrotropin - blood Triglycerides - blood |
| title | The relationship between serum thyrotropin and components of metabolic syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T21%3A17%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20relationship%20between%20serum%20thyrotropin%20and%20components%20of%20metabolic%20syndrome&rft.jtitle=ENDOCRINE%20JOURNAL&rft.au=Lai,%20Yaxin&rft.aucorp=Department%20of%20Endocrinology%20and%20Metabolism&rft.date=2011-01-01&rft.volume=58&rft.issue=1&rft.spage=23&rft.epage=30&rft.pages=23-30&rft.issn=0918-8959&rft.eissn=1348-4540&rft_id=info:doi/10.1507/endocrj.K10E-272&rft_dat=%3Cproquest_cross%3E849433786%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=849433786&rft_id=info:pmid/21135510&rfr_iscdi=true |