SAP97 and Dystrophin Macromolecular Complexes Determine Two Pools of Cardiac Sodium Channels Nav1.5 in Cardiomyocytes

RATIONALE:The cardiac sodium channel Nav1.5 plays a key role in excitability and conduction. The 3 last residues of Nav1.5 (Ser-Ile-Val) constitute a PDZ-domain binding motif that interacts with the syntrophin–dystrophin complex. As dystrophin is absent at the intercalated discs, Nav1.5 could potent...

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Veröffentlicht in:	Circulation research 2011-02, Vol.108 (3), p.294-304
Hauptverfasser:	Petitprez, Séverine, Zmoos, Anne-Flore, Ogrodnik, Jakob, Balse, Elise, Raad, Nour, El-Haou, Said, Albesa, Maxime, Bittihn, Philip, Luther, Stefan, Lehnart, Stephan E, Hatem, Stéphane N, Coulombe, Alain, Abriel, Hugues
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biological and medical sciences Cell Membrane - metabolism Cells, Cultured Connexin 43 - metabolism Discs Large Homolog 1 Protein Dystrophin - genetics Dystrophin - metabolism Dystrophin-Associated Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Silencing Guanylate Kinases HEK293 Cells Humans Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Inbred mdx Models, Animal Muscle Proteins - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism NAV1.5 Voltage-Gated Sodium Channel Patch-Clamp Techniques Rats Rats, Wistar Sodium Channels - metabolism Transfection Vertebrates: cardiovascular system
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