Outcomes of intrathecal baclofen (ITB) therapy in spacticity
Spasticity is associated with various neurological conditions. Intrathecal baclofen (ITB) is one of the popular treatments for severe spasticity. In this paper we present our experience in treating 30 patients with both spinal and supraspinal spasticity with chronic infusion of Baclofen to evaluate...
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| Veröffentlicht in: | Turkish neurosurgery 2011-01, Vol.21 (1), p.59-65 |
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| creator | Ucar, Tanju Kazan, Saim Turgut, Umut Samanci, Nehir Karaman |
| description | Spasticity is associated with various neurological conditions. Intrathecal baclofen (ITB) is one of the popular treatments for severe spasticity. In this paper we present our experience in treating 30 patients with both spinal and supraspinal spasticity with chronic infusion of Baclofen to evaluate the long term efficacy of this treatment on spasticity, disability and pain, and to evaluate the side effects of intrathecal Baclofen.
The medical records of 30 patients who underwent baclofen pump placement from 2000 to 2010 under Department of Neurosurgery at the University of Akdeniz at Antalya/Turkey, were reviewed. All study subjects had diffuse chronic, severe, and generalized spasticity (Ashworth score ≥ 3), and had shown inadequate response to various oral antispastic drugs including baclofen. All patients were evaluated by means of the Ashworth score, spasm frequency, Barthel index, Rankin scales and VAS.
Spasticity and spasm frequency and pain scores were clinically and statistically decreased in all patients.
ITB therapy increases the quality of lifestyle and functional independence by reducing not only cerebral but also spinal related spasticity in appropriately selected cases. |
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The medical records of 30 patients who underwent baclofen pump placement from 2000 to 2010 under Department of Neurosurgery at the University of Akdeniz at Antalya/Turkey, were reviewed. All study subjects had diffuse chronic, severe, and generalized spasticity (Ashworth score ≥ 3), and had shown inadequate response to various oral antispastic drugs including baclofen. All patients were evaluated by means of the Ashworth score, spasm frequency, Barthel index, Rankin scales and VAS.
Spasticity and spasm frequency and pain scores were clinically and statistically decreased in all patients.
ITB therapy increases the quality of lifestyle and functional independence by reducing not only cerebral but also spinal related spasticity in appropriately selected cases.</description><identifier>ISSN: 1019-5149</identifier><identifier>PMID: 21294093</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adolescent ; Adult ; Baclofen - administration & dosage ; Baclofen - adverse effects ; Child ; Child, Preschool ; Disability Evaluation ; Female ; Follow-Up Studies ; Humans ; Infusion Pumps, Implantable ; Injections, Spinal ; Male ; Middle Aged ; Muscle Relaxants, Central - administration & dosage ; Muscle Relaxants, Central - adverse effects ; Muscle Spasticity - drug therapy ; Pain - drug therapy ; Treatment Outcome ; Young Adult</subject><ispartof>Turkish neurosurgery, 2011-01, Vol.21 (1), p.59-65</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21294093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ucar, Tanju</creatorcontrib><creatorcontrib>Kazan, Saim</creatorcontrib><creatorcontrib>Turgut, Umut</creatorcontrib><creatorcontrib>Samanci, Nehir Karaman</creatorcontrib><title>Outcomes of intrathecal baclofen (ITB) therapy in spacticity</title><title>Turkish neurosurgery</title><addtitle>Turk Neurosurg</addtitle><description>Spasticity is associated with various neurological conditions. Intrathecal baclofen (ITB) is one of the popular treatments for severe spasticity. In this paper we present our experience in treating 30 patients with both spinal and supraspinal spasticity with chronic infusion of Baclofen to evaluate the long term efficacy of this treatment on spasticity, disability and pain, and to evaluate the side effects of intrathecal Baclofen.
The medical records of 30 patients who underwent baclofen pump placement from 2000 to 2010 under Department of Neurosurgery at the University of Akdeniz at Antalya/Turkey, were reviewed. All study subjects had diffuse chronic, severe, and generalized spasticity (Ashworth score ≥ 3), and had shown inadequate response to various oral antispastic drugs including baclofen. All patients were evaluated by means of the Ashworth score, spasm frequency, Barthel index, Rankin scales and VAS.
Spasticity and spasm frequency and pain scores were clinically and statistically decreased in all patients.
ITB therapy increases the quality of lifestyle and functional independence by reducing not only cerebral but also spinal related spasticity in appropriately selected cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Baclofen - administration & dosage</subject><subject>Baclofen - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infusion Pumps, Implantable</subject><subject>Injections, Spinal</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Relaxants, Central - administration & dosage</subject><subject>Muscle Relaxants, Central - adverse effects</subject><subject>Muscle Spasticity - drug therapy</subject><subject>Pain - drug therapy</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1019-5149</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j0tLw0AUhWeh2Fr9CzI7dRGYVx4DbrRYLRS6qetwc3MHI3k5M1nk3xuxrg4cPj7OuWBrKaRNUmnsil2H8CVElikpr9hKSWWNsHrNno5TxKGjwAfHmz56iJ-E0PIKsB0c9fxhf3p55EvrYZwXhIcRMDbYxPmGXTpoA92ec8M-dq-n7XtyOL7tt8-HZJRGxCTHuqiUBadScK5WThY6A0BwuVU6W3YYQiEpz9HZDFGJlNJUa9QFAuVWb9j9n3f0w_dEIZZdE5DaFnoaplAWxhotlf4l787kVHVUl6NvOvBz-X9Y_wA4N1BI</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Ucar, Tanju</creator><creator>Kazan, Saim</creator><creator>Turgut, Umut</creator><creator>Samanci, Nehir Karaman</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201101</creationdate><title>Outcomes of intrathecal baclofen (ITB) therapy in spacticity</title><author>Ucar, Tanju ; Kazan, Saim ; Turgut, Umut ; Samanci, Nehir Karaman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-7cd8b29af25affd2f1836aacaf792360934ec01e77cf96cc205e5533c38cae793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Baclofen - administration & dosage</topic><topic>Baclofen - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infusion Pumps, Implantable</topic><topic>Injections, Spinal</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Relaxants, Central - administration & dosage</topic><topic>Muscle Relaxants, Central - adverse effects</topic><topic>Muscle Spasticity - drug therapy</topic><topic>Pain - drug therapy</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ucar, Tanju</creatorcontrib><creatorcontrib>Kazan, Saim</creatorcontrib><creatorcontrib>Turgut, Umut</creatorcontrib><creatorcontrib>Samanci, Nehir Karaman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Turkish neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ucar, Tanju</au><au>Kazan, Saim</au><au>Turgut, Umut</au><au>Samanci, Nehir Karaman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes of intrathecal baclofen (ITB) therapy in spacticity</atitle><jtitle>Turkish neurosurgery</jtitle><addtitle>Turk Neurosurg</addtitle><date>2011-01</date><risdate>2011</risdate><volume>21</volume><issue>1</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>1019-5149</issn><abstract>Spasticity is associated with various neurological conditions. Intrathecal baclofen (ITB) is one of the popular treatments for severe spasticity. In this paper we present our experience in treating 30 patients with both spinal and supraspinal spasticity with chronic infusion of Baclofen to evaluate the long term efficacy of this treatment on spasticity, disability and pain, and to evaluate the side effects of intrathecal Baclofen.
The medical records of 30 patients who underwent baclofen pump placement from 2000 to 2010 under Department of Neurosurgery at the University of Akdeniz at Antalya/Turkey, were reviewed. All study subjects had diffuse chronic, severe, and generalized spasticity (Ashworth score ≥ 3), and had shown inadequate response to various oral antispastic drugs including baclofen. All patients were evaluated by means of the Ashworth score, spasm frequency, Barthel index, Rankin scales and VAS.
Spasticity and spasm frequency and pain scores were clinically and statistically decreased in all patients.
ITB therapy increases the quality of lifestyle and functional independence by reducing not only cerebral but also spinal related spasticity in appropriately selected cases.</abstract><cop>Turkey</cop><pmid>21294093</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Baclofen - administration & dosage Baclofen - adverse effects Child Child, Preschool Disability Evaluation Female Follow-Up Studies Humans Infusion Pumps, Implantable Injections, Spinal Male Middle Aged Muscle Relaxants, Central - administration & dosage Muscle Relaxants, Central - adverse effects Muscle Spasticity - drug therapy Pain - drug therapy Treatment Outcome Young Adult |
| title | Outcomes of intrathecal baclofen (ITB) therapy in spacticity |
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