Recombinant TFPI-2 enhances macrophage apoptosis through upregulation of Fas/FasL

Tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor with inhibitory activity toward activated factor XI, plasma kallikrein, plasmin, certain matrix metalloproteinases, and the tissue factor-activated factor VII complex. In addition, TFPI-2 has other functions such...

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Veröffentlicht in:	European journal of pharmacology 2011-03, Vol.654 (2), p.135-141
Hauptverfasser:	Pan, Jun-jie, Shi, Hai-ming, Luo, Xin-ping, Ma, Duan, Li, Yong, Zhu, Jun, Liang, Wang, Mu, Jin-gui, Li, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Atherosclerosis Atherosclerosis (general aspects, experimental research) Benzimidazoles Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Caspase-8 Caspases - metabolism cell movement death DNA DNA Fragmentation - drug effects Dose-Response Relationship, Drug factor VII Fas Ligand Protein - metabolism fas Receptor - metabolism Fas-Associated Death Domain Protein - metabolism Fas/FasL flow cytometry Fluorescent Dyes Glycoproteins - metabolism Glycoproteins - pharmacology Humans macrophages Macrophages - drug effects Macrophages - physiology Medical sciences metalloproteinases Pharmacology. Drug treatments plasma kallikrein plasmin proteinase inhibitors receptors Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Serine Proteinase Inhibitors - metabolism Serine Proteinase Inhibitors - pharmacology signal transduction Signal Transduction - drug effects Tissue factor pathway inhibitor-2 Tumor Cells, Cultured tumor necrosis factors U937 Cells Up-Regulation Western blotting
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