mTOR Signaling is Involved in Indomethacin and Nimesulide Suppression of Colorectal Cancer Cell Growth via a COX-2 Independent Pathway

Background Inhibition of mammalian target of rapamycin (mTOR) represents an attractive target for anticancer therapy, but its role in suppression of colorectal cancer (CRC) cell growth by cyclooxygenase-2 (COX-2) inhibitors is unclear. Here, we analyzed the effect of indomethacin (Indo, a nonselecti...

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Veröffentlicht in:	Annals of surgical oncology 2011-02, Vol.18 (2), p.580-588
Hauptverfasser:	Zhang, Yan-Jie, Bao, Yu-Jie, Dai, Qiang, Yang, Wen-Yan, Cheng, Peng, Zhu, Li-Ming, Wang, Bi-Jun, Jiang, Fo-Hu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blotting, Western Cell Cycle - drug effects Cell Proliferation - drug effects Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclooxygenase 2 - chemistry Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Humans Indomethacin - pharmacology Male Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Oncology RNA, Small Interfering - genetics Signal Transduction - drug effects Sulfonamides - pharmacology Surgery Surgical Oncology Translational Research and Biomarkers Tumor Cells, Cultured
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