Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis With Emphasis on Pathologic and Cytopathologic Features
This study presents a case of juxtaglomerular cell tumor (JCT) in a 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round e...
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| Veröffentlicht in: | International journal of surgical pathology 2011-02, Vol.19 (1), p.93-98 |
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| container_title | International journal of surgical pathology |
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| creator | Méndez, Gonzalo P. Klock, Clóvis Nosé, Vânia |
| description | This study presents a case of juxtaglomerular cell tumor (JCT) in a 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round epithelioid cells with eosinophilic granular cytoplasm, and distinct cell borders in a background of widespread hemorrhage. Electron microscopy revealed cytoplasmic renin granules. The differential diagnosis of a renal mass in a young patient with hypertension includes JCT, Wilm’s tumor, and renal cell carcinoma, which may produce renin. The renin granules detected by electron microscopy are characteristic of JCT, and the diagnosis is confirmed by ultrastructural study. FNA cytology is not sensitive enough for the diagnosis of JCT and its results must be carefully interpreted. |
| doi_str_mv | 10.1177/1066896908329413 |
| format | Article |
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Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round epithelioid cells with eosinophilic granular cytoplasm, and distinct cell borders in a background of widespread hemorrhage. Electron microscopy revealed cytoplasmic renin granules. The differential diagnosis of a renal mass in a young patient with hypertension includes JCT, Wilm’s tumor, and renal cell carcinoma, which may produce renin. The renin granules detected by electron microscopy are characteristic of JCT, and the diagnosis is confirmed by ultrastructural study. FNA cytology is not sensitive enough for the diagnosis of JCT and its results must be carefully interpreted.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896908329413</identifier><identifier>PMID: 19098017</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Carcinoma, Papillary - pathology ; Carcinoma, Papillary - secretion ; Carcinoma, Papillary - surgery ; Carcinoma, Renal Cell - pathology ; Child ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; Juxtaglomerular Apparatus - pathology ; Juxtaglomerular Apparatus - secretion ; Juxtaglomerular Apparatus - surgery ; Kidney Neoplasms - pathology ; Kidney Neoplasms - secretion ; Kidney Neoplasms - surgery ; Microscopy, Electron ; Nephrectomy ; Renin - secretion ; Wilms Tumor - pathology</subject><ispartof>International journal of surgical pathology, 2011-02, Vol.19 (1), p.93-98</ispartof><rights>The Author(s) 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-5b6089ad6e03674f2e793b0fce3bedc1f07df8dfa869bdad5bc126a89f61be593</citedby><cites>FETCH-LOGICAL-c336t-5b6089ad6e03674f2e793b0fce3bedc1f07df8dfa869bdad5bc126a89f61be593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1066896908329413$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1066896908329413$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19098017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Méndez, Gonzalo P.</creatorcontrib><creatorcontrib>Klock, Clóvis</creatorcontrib><creatorcontrib>Nosé, Vânia</creatorcontrib><title>Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis With Emphasis on Pathologic and Cytopathologic Features</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>This study presents a case of juxtaglomerular cell tumor (JCT) in a 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round epithelioid cells with eosinophilic granular cytoplasm, and distinct cell borders in a background of widespread hemorrhage. Electron microscopy revealed cytoplasmic renin granules. The differential diagnosis of a renal mass in a young patient with hypertension includes JCT, Wilm’s tumor, and renal cell carcinoma, which may produce renin. The renin granules detected by electron microscopy are characteristic of JCT, and the diagnosis is confirmed by ultrastructural study. FNA cytology is not sensitive enough for the diagnosis of JCT and its results must be carefully interpreted.</description><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - secretion</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Child</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Juxtaglomerular Apparatus - pathology</subject><subject>Juxtaglomerular Apparatus - secretion</subject><subject>Juxtaglomerular Apparatus - surgery</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - secretion</subject><subject>Kidney Neoplasms - surgery</subject><subject>Microscopy, Electron</subject><subject>Nephrectomy</subject><subject>Renin - secretion</subject><subject>Wilms Tumor - pathology</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UMtq3DAUFSWleXXfVdAuK6dXtkeWsivOJGkaSCkJXZpr62rGwbZcSYbMH_Sz4-kMBAJd3cd5wDmMfRFwIURRfBUgpdJSg8pSnYvsAzsSOockzeXiYN5nONnih-w4hGcASGUqPrFDoUErEMUR-3s3vURcda4nP3XoeUldxx-n3nnuLI9r4j9aM9DmkpcYiP-i0fnIcTD8qrWWPA2xxW4-cDW40Ab-u41rvuzHNW4vN_CfGNeuc6u2-ScrN9GNb69rwjh5Cqfso8Uu0Of9PGFP18vH8ja5f7j5Xn67T5oskzFZ1BKURiMJMlnkNqVCZzXYhrKaTCMsFMYqY1FJXRs0i7oRqUSlrRQ1LXR2ws53vqN3fyYKserb0MyhcSA3hUrlGkAVqpiZsGM23oXgyVajb3v0m0pAta2_el__LDnbm091T-ZNsO97JiQ7QsAVVc9u8sMc9v-Gr4yrj60</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Méndez, Gonzalo P.</creator><creator>Klock, Clóvis</creator><creator>Nosé, Vânia</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201102</creationdate><title>Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis With Emphasis on Pathologic and Cytopathologic Features</title><author>Méndez, Gonzalo P. ; Klock, Clóvis ; Nosé, Vânia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-5b6089ad6e03674f2e793b0fce3bedc1f07df8dfa869bdad5bc126a89f61be593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - secretion</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Child</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Juxtaglomerular Apparatus - pathology</topic><topic>Juxtaglomerular Apparatus - secretion</topic><topic>Juxtaglomerular Apparatus - surgery</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - secretion</topic><topic>Kidney Neoplasms - surgery</topic><topic>Microscopy, Electron</topic><topic>Nephrectomy</topic><topic>Renin - secretion</topic><topic>Wilms Tumor - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Méndez, Gonzalo P.</creatorcontrib><creatorcontrib>Klock, Clóvis</creatorcontrib><creatorcontrib>Nosé, Vânia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Méndez, Gonzalo P.</au><au>Klock, Clóvis</au><au>Nosé, Vânia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis With Emphasis on Pathologic and Cytopathologic Features</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2011-02</date><risdate>2011</risdate><volume>19</volume><issue>1</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>This study presents a case of juxtaglomerular cell tumor (JCT) in a 12-year-old girl with hypertension. Fine needle aspirate (FNA) cytology demonstrated a neoplasm with features of a papillary carcinoma, prompting a right radical nephrectomy. Histological examination revealed solid sheets of round epithelioid cells with eosinophilic granular cytoplasm, and distinct cell borders in a background of widespread hemorrhage. Electron microscopy revealed cytoplasmic renin granules. The differential diagnosis of a renal mass in a young patient with hypertension includes JCT, Wilm’s tumor, and renal cell carcinoma, which may produce renin. The renin granules detected by electron microscopy are characteristic of JCT, and the diagnosis is confirmed by ultrastructural study. FNA cytology is not sensitive enough for the diagnosis of JCT and its results must be carefully interpreted.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>19098017</pmid><doi>10.1177/1066896908329413</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of surgical pathology, 2011-02, Vol.19 (1), p.93-98 |
| issn | 1066-8969 1940-2465 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Carcinoma, Papillary - pathology Carcinoma, Papillary - secretion Carcinoma, Papillary - surgery Carcinoma, Renal Cell - pathology Child Diagnosis, Differential Female Humans Immunohistochemistry Juxtaglomerular Apparatus - pathology Juxtaglomerular Apparatus - secretion Juxtaglomerular Apparatus - surgery Kidney Neoplasms - pathology Kidney Neoplasms - secretion Kidney Neoplasms - surgery Microscopy, Electron Nephrectomy Renin - secretion Wilms Tumor - pathology |
| title | Juxtaglomerular Cell Tumor of the Kidney: Case Report and Differential Diagnosis With Emphasis on Pathologic and Cytopathologic Features |
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