Cocarboxylase in Experimental Diabetes
IN previous experiments we have found that the injection of cocarboxylase causes, in the alloxandiabetic rat, a diminution of the blood sugar and an increase of the respiratory quotient and of tissue glycogen. Thiamine produces similar effects; however, with severely affected animals it fails to act...
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| Veröffentlicht in: | Nature (London) 1951-09, Vol.168 (4271), p.422-422 |
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| container_title | Nature (London) |
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| creator | SILIPRANDI, D SILIPRANDI, N |
| description | IN previous experiments we have found that the injection of cocarboxylase causes, in the alloxandiabetic rat, a diminution of the blood sugar and an increase of the respiratory quotient and of tissue glycogen. Thiamine produces similar effects; however, with severely affected animals it fails to act
1,2
. The hypothesis was then advanced that, in severe alloxan diabetes, thiamine does not produce any effect because its conversion to cocarboxylase is prevented. We have now obtained some evidence in support of this hypothesis. |
| doi_str_mv | 10.1038/168422a0 |
| format | Article |
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1,2
. The hypothesis was then advanced that, in severe alloxan diabetes, thiamine does not produce any effect because its conversion to cocarboxylase is prevented. We have now obtained some evidence in support of this hypothesis.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/168422a0</identifier><identifier>PMID: 14875108</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Diabetes Mellitus, Experimental ; Humanities and Social Sciences ; letter ; multidisciplinary ; Old Medline ; Science ; Science (multidisciplinary) ; Thiamine Pyrophosphate - metabolism</subject><ispartof>Nature (London), 1951-09, Vol.168 (4271), p.422-422</ispartof><rights>Springer Nature Limited 1951</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4e49d80728662596499c05809a11d10c2109d3517c1bf4bac37419c7959238e43</citedby><cites>FETCH-LOGICAL-c372t-4e49d80728662596499c05809a11d10c2109d3517c1bf4bac37419c7959238e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/168422a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/168422a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14875108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SILIPRANDI, D</creatorcontrib><creatorcontrib>SILIPRANDI, N</creatorcontrib><title>Cocarboxylase in Experimental Diabetes</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IN previous experiments we have found that the injection of cocarboxylase causes, in the alloxandiabetic rat, a diminution of the blood sugar and an increase of the respiratory quotient and of tissue glycogen. Thiamine produces similar effects; however, with severely affected animals it fails to act
1,2
. The hypothesis was then advanced that, in severe alloxan diabetes, thiamine does not produce any effect because its conversion to cocarboxylase is prevented. We have now obtained some evidence in support of this hypothesis.</description><subject>Animals</subject><subject>Diabetes Mellitus, Experimental</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Thiamine Pyrophosphate - metabolism</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1951</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqUg8QtQpwqGwJ3jxPaISvmQKrHAbDnOFaVKk2InUvvva9RW3ZhuuOcevfcydovwiJCqJ8yV4NzCGRuikHkiciXP2RCAqwRUmg_YVQhLAMhQiks2QKFkhqCGbDJtnfVFu9nWNtC4asazzZp8taKms_X4pbIFdRSu2cXC1oFuDnPEvl9nX9P3ZP759jF9niculbxLBAldKpBc5TnPdC60dpAp0BaxRHAcQZdpDOGwWIjCxiuB2kmdaZ4qEumITfbetW9_ewqdWVXBUV3bhto-GCWUFvHXCN7vQefbEDwtzDqGtn5rEMxfJ-bYSUTvDs6-WFF5Ag8lROBhD4S4an7Im2Xb-yb--Y-ssV3v6SQ7AjsXAW_B</recordid><startdate>19510908</startdate><enddate>19510908</enddate><creator>SILIPRANDI, D</creator><creator>SILIPRANDI, N</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19510908</creationdate><title>Cocarboxylase in Experimental Diabetes</title><author>SILIPRANDI, D ; SILIPRANDI, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4e49d80728662596499c05809a11d10c2109d3517c1bf4bac37419c7959238e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1951</creationdate><topic>Animals</topic><topic>Diabetes Mellitus, Experimental</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Thiamine Pyrophosphate - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SILIPRANDI, D</creatorcontrib><creatorcontrib>SILIPRANDI, N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SILIPRANDI, D</au><au>SILIPRANDI, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cocarboxylase in Experimental Diabetes</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1951-09-08</date><risdate>1951</risdate><volume>168</volume><issue>4271</issue><spage>422</spage><epage>422</epage><pages>422-422</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>IN previous experiments we have found that the injection of cocarboxylase causes, in the alloxandiabetic rat, a diminution of the blood sugar and an increase of the respiratory quotient and of tissue glycogen. Thiamine produces similar effects; however, with severely affected animals it fails to act
1,2
. The hypothesis was then advanced that, in severe alloxan diabetes, thiamine does not produce any effect because its conversion to cocarboxylase is prevented. We have now obtained some evidence in support of this hypothesis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14875108</pmid><doi>10.1038/168422a0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature (London), 1951-09, Vol.168 (4271), p.422-422 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Animals Diabetes Mellitus, Experimental Humanities and Social Sciences letter multidisciplinary Old Medline Science Science (multidisciplinary) Thiamine Pyrophosphate - metabolism |
| title | Cocarboxylase in Experimental Diabetes |
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