Effect of a Nonionic Surface-Active Polymer on Passage of Hydrocortisone Across Rat Intestine In Vitro

Employing the Crane and Wilson everted sac technique, the passage of hydrocortisone cortisol—in micellar solutions of oxyethylated tertiary octylphenol polymethylene polymer (tyloxapol)—from the mucosal to the serosal side of the rat intestinal membrane was studied. It was determined that the mechan...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1968-05, Vol.57 (5), p.836-841
1. Verfasser:	Saski, Witold
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Colorimetric analysis Diffusion rate-tyloxapol concentration function effect-cortisol diffusion Everted sac-technique Female Hydrocortisone - metabolism Hydrocortisone diffusion Hydrocortisone diffusion, in vitro—rat intestine In Vitro Techniques in vitro-rat intestine Intestinal Mucosa - metabolism Intestines - drug effects Mathematics Polymers - pharmacology Rats Surface-Active Agents - pharmacology Tyloxapol Tyloxapol, effect—cortisol diffusion Viscosity
Online-Zugang:	Volltext
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