Effect of a Nonionic Surface-Active Polymer on Passage of Hydrocortisone Across Rat Intestine In Vitro
Employing the Crane and Wilson everted sac technique, the passage of hydrocortisone cortisol—in micellar solutions of oxyethylated tertiary octylphenol polymethylene polymer (tyloxapol)—from the mucosal to the serosal side of the rat intestinal membrane was studied. It was determined that the mechan...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1968-05, Vol.57 (5), p.836-841 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Saski, Witold |
| description | Employing the Crane and Wilson everted sac technique, the passage of hydrocortisone cortisol—in micellar solutions of oxyethylated tertiary octylphenol polymethylene polymer (tyloxapol)—from the mucosal to the serosal side of the rat intestinal membrane was studied. It was determined that the mechanism by which cortisol passes across the membrane is that of diffusion. However, it was found that the relative rate of passage of cortisol dissolved in micellar solutions of tyloxapol is a function of concentration of the solubilizing agent used and is inversely proportional to the concentration of tyloxapol and viscosity of the solution tested. |
| doi_str_mv | 10.1002/jps.2600570525 |
| format | Article |
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It was determined that the mechanism by which cortisol passes across the membrane is that of diffusion. However, it was found that the relative rate of passage of cortisol dissolved in micellar solutions of tyloxapol is a function of concentration of the solubilizing agent used and is inversely proportional to the concentration of tyloxapol and viscosity of the solution tested.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600570525</identifier><identifier>PMID: 5657546</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Absorption ; Animals ; Colorimetric analysis ; Diffusion rate-tyloxapol concentration function ; effect-cortisol diffusion ; Everted sac-technique ; Female ; Hydrocortisone - metabolism ; Hydrocortisone diffusion ; Hydrocortisone diffusion, in vitro—rat intestine ; In Vitro Techniques ; in vitro-rat intestine ; Intestinal Mucosa - metabolism ; Intestines - drug effects ; Mathematics ; Polymers - pharmacology ; Rats ; Surface-Active Agents - pharmacology ; Tyloxapol ; Tyloxapol, effect—cortisol diffusion ; Viscosity</subject><ispartof>Journal of pharmaceutical sciences, 1968-05, Vol.57 (5), p.836-841</ispartof><rights>1968 Wiley‐Liss, Inc., A Wiley Company</rights><rights>Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4275-9037f93ea6e4058782201fdb0f64942ffb5705f09fa1847923bae0af7748addf3</citedby><cites>FETCH-LOGICAL-c4275-9037f93ea6e4058782201fdb0f64942ffb5705f09fa1847923bae0af7748addf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600570525$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600570525$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5657546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saski, Witold</creatorcontrib><title>Effect of a Nonionic Surface-Active Polymer on Passage of Hydrocortisone Across Rat Intestine In Vitro</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Employing the Crane and Wilson everted sac technique, the passage of hydrocortisone cortisol—in micellar solutions of oxyethylated tertiary octylphenol polymethylene polymer (tyloxapol)—from the mucosal to the serosal side of the rat intestinal membrane was studied. It was determined that the mechanism by which cortisol passes across the membrane is that of diffusion. However, it was found that the relative rate of passage of cortisol dissolved in micellar solutions of tyloxapol is a function of concentration of the solubilizing agent used and is inversely proportional to the concentration of tyloxapol and viscosity of the solution tested.</description><subject>Absorption</subject><subject>Animals</subject><subject>Colorimetric analysis</subject><subject>Diffusion rate-tyloxapol concentration function</subject><subject>effect-cortisol diffusion</subject><subject>Everted sac-technique</subject><subject>Female</subject><subject>Hydrocortisone - metabolism</subject><subject>Hydrocortisone diffusion</subject><subject>Hydrocortisone diffusion, in vitro—rat intestine</subject><subject>In Vitro Techniques</subject><subject>in vitro-rat intestine</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestines - drug effects</subject><subject>Mathematics</subject><subject>Polymers - pharmacology</subject><subject>Rats</subject><subject>Surface-Active Agents - pharmacology</subject><subject>Tyloxapol</subject><subject>Tyloxapol, effect—cortisol diffusion</subject><subject>Viscosity</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvEzEQhS0EKmnhyg3JJ24bxl57vXuMotIGVSVNoRwtxztGLpt1sDeF_Ps6bFTEASFZGsnzvaeZN4S8YTBlAPz9_TZNeQUgFUgun5EJkxyKCph6TiYZ4EUpRfOSnKZ0DwAVSHlCTmQllRTVhLhz59AONDhq6HXofX6W3u6iMxaLmR38A9Jl6PYbjDT0dGlSMt_wwF_u2xhsiINPoUc6szGkRFdmoIt-wDT4_Lno6Z0fYnhFXjjTJXx9rGfky4fzz_PL4urTxWI-uyqs4EoWDZTKNSWaCgXIWtWcA3PtGlwlGsGdWx_WdNA4w2qhGl6uDYJxSonatK0rz8i70Xcbw49dHkJvfLLYdabHsEu6FnVdiqbM4HQEf08d0elt9BsT95qBPgSrc7D6T7BZ8PbovFtvsH3Cj0nmfjP2f_oO9_9x0x-Xt395F6PWpwF_PWlN_K4rVSqpv15f6DvGVzc3bK5Xma9HHnOUDx6jTtZjb7H1MR9Tt8H_a41H1eSmKQ</recordid><startdate>196805</startdate><enddate>196805</enddate><creator>Saski, Witold</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196805</creationdate><title>Effect of a Nonionic Surface-Active Polymer on Passage of Hydrocortisone Across Rat Intestine In Vitro</title><author>Saski, Witold</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4275-9037f93ea6e4058782201fdb0f64942ffb5705f09fa1847923bae0af7748addf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Colorimetric analysis</topic><topic>Diffusion rate-tyloxapol concentration function</topic><topic>effect-cortisol diffusion</topic><topic>Everted sac-technique</topic><topic>Female</topic><topic>Hydrocortisone - metabolism</topic><topic>Hydrocortisone diffusion</topic><topic>Hydrocortisone diffusion, in vitro—rat intestine</topic><topic>In Vitro Techniques</topic><topic>in vitro-rat intestine</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestines - drug effects</topic><topic>Mathematics</topic><topic>Polymers - pharmacology</topic><topic>Rats</topic><topic>Surface-Active Agents - pharmacology</topic><topic>Tyloxapol</topic><topic>Tyloxapol, effect—cortisol diffusion</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saski, Witold</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saski, Witold</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a Nonionic Surface-Active Polymer on Passage of Hydrocortisone Across Rat Intestine In Vitro</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1968-05</date><risdate>1968</risdate><volume>57</volume><issue>5</issue><spage>836</spage><epage>841</epage><pages>836-841</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Employing the Crane and Wilson everted sac technique, the passage of hydrocortisone cortisol—in micellar solutions of oxyethylated tertiary octylphenol polymethylene polymer (tyloxapol)—from the mucosal to the serosal side of the rat intestinal membrane was studied. It was determined that the mechanism by which cortisol passes across the membrane is that of diffusion. However, it was found that the relative rate of passage of cortisol dissolved in micellar solutions of tyloxapol is a function of concentration of the solubilizing agent used and is inversely proportional to the concentration of tyloxapol and viscosity of the solution tested.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5657546</pmid><doi>10.1002/jps.2600570525</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1968-05, Vol.57 (5), p.836-841 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Absorption Animals Colorimetric analysis Diffusion rate-tyloxapol concentration function effect-cortisol diffusion Everted sac-technique Female Hydrocortisone - metabolism Hydrocortisone diffusion Hydrocortisone diffusion, in vitro—rat intestine In Vitro Techniques in vitro-rat intestine Intestinal Mucosa - metabolism Intestines - drug effects Mathematics Polymers - pharmacology Rats Surface-Active Agents - pharmacology Tyloxapol Tyloxapol, effect—cortisol diffusion Viscosity |
| title | Effect of a Nonionic Surface-Active Polymer on Passage of Hydrocortisone Across Rat Intestine In Vitro |
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