MONKEY POX. I. CLINICAL, VIROLOGIC AND IMMUNOLOGIC STUDIES
Wenner, H. A. (Dep't. of Pediatrics, Univ. of Kansas Med. Ctr., Kansas Gty, Kara. 66103), F. D. Macasaet, P. S. Kamitsuka and P. Kidd. Monkey pox. I. Clinical, virologic and immunologic studies. Amer. J. Epid., 1968, 87: 551–556.—Monkeys inoculated with monkey pox virus (MPV) regularly develop...
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| Veröffentlicht in: | American journal of epidemiology 1968-05, Vol.87 (3), p.551-566 |
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| container_title | American journal of epidemiology |
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| creator | WENNER, HERBERT A. MACASAET, FRANCISCO D. KAMITSUKA, PAUL S. KIDD, PATRICIA |
| description | Wenner, H. A. (Dep't. of Pediatrics, Univ. of Kansas Med. Ctr., Kansas Gty, Kara. 66103), F. D. Macasaet, P. S. Kamitsuka and P. Kidd. Monkey pox. I. Clinical, virologic and immunologic studies. Amer. J. Epid., 1968, 87: 551–556.—Monkeys inoculated with monkey pox virus (MPV) regularly develop a pox eruption. The rash is more pronounced in cynomolgus (M. irus) than in rhesus (M. mulatto) monkeys. Viremia was demonstrable in 11 of 34 experimentally infected animals. MPV was recovered principally from spleen and lymph nodes during the preeruptive period, from several other visceral organs at onset of rash, and from cutaneous lesions and lymph nodes for several days after onset of rash. Specific antibodies developed at the time of appearance, or shortly after onset of rash. Hemagglutination-inhibition (HI) antibodies reached maximal levels and declined during the period when serum neutralizing antibodies were rising. Histologically, the reactions of injury resemble those described for variola and vaccinia. Monkeys recovering from monkey pox were immune to vaccinia virus. A comparison of our data with others indicates that pathogenetic features of MPV infection resemble those described for variola. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a120846 |
| format | Article |
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CLINICAL, VIROLOGIC AND IMMUNOLOGIC STUDIES</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><source>Periodicals Index Online</source><creator>WENNER, HERBERT A. ; MACASAET, FRANCISCO D. ; KAMITSUKA, PAUL S. ; KIDD, PATRICIA</creator><creatorcontrib>WENNER, HERBERT A. ; MACASAET, FRANCISCO D. ; KAMITSUKA, PAUL S. ; KIDD, PATRICIA</creatorcontrib><description>Wenner, H. A. (Dep't. of Pediatrics, Univ. of Kansas Med. Ctr., Kansas Gty, Kara. 66103), F. D. Macasaet, P. S. Kamitsuka and P. Kidd. Monkey pox. I. Clinical, virologic and immunologic studies. Amer. J. Epid., 1968, 87: 551–556.—Monkeys inoculated with monkey pox virus (MPV) regularly develop a pox eruption. The rash is more pronounced in cynomolgus (M. irus) than in rhesus (M. mulatto) monkeys. Viremia was demonstrable in 11 of 34 experimentally infected animals. MPV was recovered principally from spleen and lymph nodes during the preeruptive period, from several other visceral organs at onset of rash, and from cutaneous lesions and lymph nodes for several days after onset of rash. Specific antibodies developed at the time of appearance, or shortly after onset of rash. Hemagglutination-inhibition (HI) antibodies reached maximal levels and declined during the period when serum neutralizing antibodies were rising. Histologically, the reactions of injury resemble those described for variola and vaccinia. Monkeys recovering from monkey pox were immune to vaccinia virus. 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I. CLINICAL, VIROLOGIC AND IMMUNOLOGIC STUDIES</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Wenner, H. A. (Dep't. of Pediatrics, Univ. of Kansas Med. Ctr., Kansas Gty, Kara. 66103), F. D. Macasaet, P. S. Kamitsuka and P. Kidd. Monkey pox. I. Clinical, virologic and immunologic studies. Amer. J. Epid., 1968, 87: 551–556.—Monkeys inoculated with monkey pox virus (MPV) regularly develop a pox eruption. The rash is more pronounced in cynomolgus (M. irus) than in rhesus (M. mulatto) monkeys. Viremia was demonstrable in 11 of 34 experimentally infected animals. MPV was recovered principally from spleen and lymph nodes during the preeruptive period, from several other visceral organs at onset of rash, and from cutaneous lesions and lymph nodes for several days after onset of rash. Specific antibodies developed at the time of appearance, or shortly after onset of rash. Hemagglutination-inhibition (HI) antibodies reached maximal levels and declined during the period when serum neutralizing antibodies were rising. Histologically, the reactions of injury resemble those described for variola and vaccinia. Monkeys recovering from monkey pox were immune to vaccinia virus. A comparison of our data with others indicates that pathogenetic features of MPV infection resemble those described for variola.</description><subject>Animals</subject><subject>Exanthema - etiology</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Monkey Diseases - immunology</subject><subject>Monkey Diseases - microbiology</subject><subject>Neutralization Tests</subject><subject>Poxviridae - isolation & purification</subject><subject>Poxviridae Infections - immunology</subject><subject>Poxviridae Infections - microbiology</subject><subject>Vaccination</subject><subject>Vaccinia virus - immunology</subject><subject>Virus Cultivation</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNpdkEtLw0AUhQdRaq3-BCEouDJx3jNx15c2miZiH9ZuhjQzgdS2qUkD9d8bbHTh6nD5Pu6BA8AVgg6CLrnL9kmW62VW5ptoVTjR0jgRwlBSfgSaiApuc8z4MWhCCLHtYo5PwVlRLCFEyGWwARoUu4Ij1gT3wzB47r9bL-HMsTzH6vpe4HXb_q019V5DP3z0ulY76FnecDgJ6ns0nvS8_ugcnCRVvbmoswUmD_1xd2D_WG3fTpEUOzt2NZOEaa6ZRiSiyUK4QkBDENNJJDBiMRKxxJxqymKhdWw0xYgvpORxIlzSAjeHv9s8-yxNsVPrtIjNahVtTFYWSlIpiJS4Eq__ib8TKUQg5xRiRCvrsrbKxdpotc3TdZR_qXqSitsHnhY7s__DUf6huCCCqcFsroJp58l_cztqTr4B1u9wcQ</recordid><startdate>196805</startdate><enddate>196805</enddate><creator>WENNER, HERBERT A.</creator><creator>MACASAET, FRANCISCO D.</creator><creator>KAMITSUKA, PAUL S.</creator><creator>KIDD, PATRICIA</creator><general>Oxford University Press</general><general>School of Hygiene and Public Health of the Johns Hopkins University</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>HVZBN</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>196805</creationdate><title>MONKEY POX. I. CLINICAL, VIROLOGIC AND IMMUNOLOGIC STUDIES</title><author>WENNER, HERBERT A. ; MACASAET, FRANCISCO D. ; KAMITSUKA, PAUL S. ; KIDD, PATRICIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i187t-c9d5835d6d5d13a4fb79770e315dfa7215c17c8264d45c7ddced4216b886cf793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Animals</topic><topic>Exanthema - etiology</topic><topic>Hemagglutination Inhibition Tests</topic><topic>Monkey Diseases - immunology</topic><topic>Monkey Diseases - microbiology</topic><topic>Neutralization Tests</topic><topic>Poxviridae - isolation & purification</topic><topic>Poxviridae Infections - immunology</topic><topic>Poxviridae Infections - microbiology</topic><topic>Vaccination</topic><topic>Vaccinia virus - immunology</topic><topic>Virus Cultivation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WENNER, HERBERT A.</creatorcontrib><creatorcontrib>MACASAET, FRANCISCO D.</creatorcontrib><creatorcontrib>KAMITSUKA, PAUL S.</creatorcontrib><creatorcontrib>KIDD, PATRICIA</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Periodicals Index Online Segment 24</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WENNER, HERBERT A.</au><au>MACASAET, FRANCISCO D.</au><au>KAMITSUKA, PAUL S.</au><au>KIDD, PATRICIA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MONKEY POX. I. CLINICAL, VIROLOGIC AND IMMUNOLOGIC STUDIES</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1968-05</date><risdate>1968</risdate><volume>87</volume><issue>3</issue><spage>551</spage><epage>566</epage><pages>551-566</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><abstract>Wenner, H. A. (Dep't. of Pediatrics, Univ. of Kansas Med. Ctr., Kansas Gty, Kara. 66103), F. D. Macasaet, P. S. Kamitsuka and P. Kidd. Monkey pox. I. Clinical, virologic and immunologic studies. Amer. J. Epid., 1968, 87: 551–556.—Monkeys inoculated with monkey pox virus (MPV) regularly develop a pox eruption. The rash is more pronounced in cynomolgus (M. irus) than in rhesus (M. mulatto) monkeys. Viremia was demonstrable in 11 of 34 experimentally infected animals. MPV was recovered principally from spleen and lymph nodes during the preeruptive period, from several other visceral organs at onset of rash, and from cutaneous lesions and lymph nodes for several days after onset of rash. Specific antibodies developed at the time of appearance, or shortly after onset of rash. Hemagglutination-inhibition (HI) antibodies reached maximal levels and declined during the period when serum neutralizing antibodies were rising. Histologically, the reactions of injury resemble those described for variola and vaccinia. Monkeys recovering from monkey pox were immune to vaccinia virus. A comparison of our data with others indicates that pathogenetic features of MPV infection resemble those described for variola.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>4297615</pmid><doi>10.1093/oxfordjournals.aje.a120846</doi><tpages>16</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Periodicals Index Online |
| subjects | Animals Exanthema - etiology Hemagglutination Inhibition Tests Monkey Diseases - immunology Monkey Diseases - microbiology Neutralization Tests Poxviridae - isolation & purification Poxviridae Infections - immunology Poxviridae Infections - microbiology Vaccination Vaccinia virus - immunology Virus Cultivation |
| title | MONKEY POX. I. CLINICAL, VIROLOGIC AND IMMUNOLOGIC STUDIES |
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