Correlation between gray/white matter volume and cognition in healthy elderly people
This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well p...
Gespeichert in:
| Veröffentlicht in: | Brain and cognition 2011-03, Vol.75 (2), p.170-176 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 176 |
|---|---|
| container_issue | 2 |
| container_start_page | 170 |
| container_title | Brain and cognition |
| container_volume | 75 |
| creator | Taki, Yasuyuki Kinomura, Shigeo Sato, Kazunori Goto, Ryoi Wu, Kai Kawashima, Ryuta Fukuda, Hiroshi |
| description | This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109 community-dwelling healthy elderly individuals. We used the Information and Digit Span subtests of the Wechsler Adult Intelligent Scale-Revised as measures of semantic memory and short-term memory, respectively. We found significant positive correlations between the gray matter ratio, the percentage of gray matter volume in the intracranial volume, and performance on the Digit Span subtest, and between the regional gray matter volumes of the bilateral anterior temporal lobes and performance on the Information subtest. No significant correlations between performance on the cognitive tests and white matter volume were found. Our results suggest that individual variability in specific cognitive functions that are relatively well preserved with aging is accounted for by the variability of gray matter volume in healthy elderly subjects. |
| doi_str_mv | 10.1016/j.bandc.2010.11.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_848686791</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ericid>EJ913147</ericid><els_id>S0278262610001636</els_id><sourcerecordid>848686791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-f811b9225e921d934cb768751430eaaa923d3a117d3fda898a4a5dbed408b35b3</originalsourceid><addsrcrecordid>eNp9kU1vEzEQhi0EoqHlF4DQXhCnTT32ftgHDigq0KoSl_Zsee3ZxpF3HWynVf49ThPKjZOleZ8Zj54h5APQJVDoLjfLQc_WLBk9VGBJqXhFFkAlrRk0_WuyoKwXNetYd0bepbShlMqGsbfkjAFwAAYLcrcKMaLX2YW5GjA_Ic7VQ9T7y6e1y1hNOmeM1WPwuwmr8l9lwsPsnnE3V2vUPq_3FXqL0e-rLYatxwvyZtQ-4fvTe07uv1_drX7Wt79-XK--3dam6dtcjwJgkIy1KBlYyRsz9J3oW2g4Ra21ZNxyDdBbPlotpNCNbu2AtqFi4O3Az8mX49xtDL93mLKaXDLovZ4x7JISjehE10soJD-SJoaUIo5qG92k414BVQebaqOebaqDTQWgis3S9ek0fzdMaF96_uorwOcToJPRfox6Ni7947hkfTlI4T4eOYzOvMRXN2WzcqkSfz3FRdajw6iScTgbtC6iycoG9989_wD3zp0X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>848686791</pqid></control><display><type>article</type><title>Correlation between gray/white matter volume and cognition in healthy elderly people</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Taki, Yasuyuki ; Kinomura, Shigeo ; Sato, Kazunori ; Goto, Ryoi ; Wu, Kai ; Kawashima, Ryuta ; Fukuda, Hiroshi</creator><creatorcontrib>Taki, Yasuyuki ; Kinomura, Shigeo ; Sato, Kazunori ; Goto, Ryoi ; Wu, Kai ; Kawashima, Ryuta ; Fukuda, Hiroshi</creatorcontrib><description>This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109 community-dwelling healthy elderly individuals. We used the Information and Digit Span subtests of the Wechsler Adult Intelligent Scale-Revised as measures of semantic memory and short-term memory, respectively. We found significant positive correlations between the gray matter ratio, the percentage of gray matter volume in the intracranial volume, and performance on the Digit Span subtest, and between the regional gray matter volumes of the bilateral anterior temporal lobes and performance on the Information subtest. No significant correlations between performance on the cognitive tests and white matter volume were found. Our results suggest that individual variability in specific cognitive functions that are relatively well preserved with aging is accounted for by the variability of gray matter volume in healthy elderly subjects.</description><identifier>ISSN: 0278-2626</identifier><identifier>EISSN: 1090-2147</identifier><identifier>DOI: 10.1016/j.bandc.2010.11.008</identifier><identifier>PMID: 21131121</identifier><identifier>CODEN: BRCOEI</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult. Elderly ; Aged ; Aging ; Aging - physiology ; Biological and medical sciences ; Brain ; Brain - anatomy & histology ; Brain - physiology ; Brain Mapping ; Cognition ; Cognition - physiology ; Cognitive Processes ; Cognitive Tests ; Comparative Analysis ; Correlation ; Developmental psychology ; Digit Span Test (Case and Kurland) ; Elderly ; Evaluation Methods ; Female ; Fundamental and applied biological sciences. Psychology ; Gray matter ; Health ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Memory - physiology ; Neuropsychological Tests ; Older Adults ; Organ Size ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Science Education ; Scientific Concepts ; Semantic memory ; Semantics ; Semiotics ; Short Term Memory ; Visual Stimuli ; Wechsler Adult Intelligence Scale (Revised) ; White matter</subject><ispartof>Brain and cognition, 2011-03, Vol.75 (2), p.170-176</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-f811b9225e921d934cb768751430eaaa923d3a117d3fda898a4a5dbed408b35b3</citedby><cites>FETCH-LOGICAL-c475t-f811b9225e921d934cb768751430eaaa923d3a117d3fda898a4a5dbed408b35b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bandc.2010.11.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ913147$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23927109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21131121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taki, Yasuyuki</creatorcontrib><creatorcontrib>Kinomura, Shigeo</creatorcontrib><creatorcontrib>Sato, Kazunori</creatorcontrib><creatorcontrib>Goto, Ryoi</creatorcontrib><creatorcontrib>Wu, Kai</creatorcontrib><creatorcontrib>Kawashima, Ryuta</creatorcontrib><creatorcontrib>Fukuda, Hiroshi</creatorcontrib><title>Correlation between gray/white matter volume and cognition in healthy elderly people</title><title>Brain and cognition</title><addtitle>Brain Cogn</addtitle><description>This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109 community-dwelling healthy elderly individuals. We used the Information and Digit Span subtests of the Wechsler Adult Intelligent Scale-Revised as measures of semantic memory and short-term memory, respectively. We found significant positive correlations between the gray matter ratio, the percentage of gray matter volume in the intracranial volume, and performance on the Digit Span subtest, and between the regional gray matter volumes of the bilateral anterior temporal lobes and performance on the Information subtest. No significant correlations between performance on the cognitive tests and white matter volume were found. Our results suggest that individual variability in specific cognitive functions that are relatively well preserved with aging is accounted for by the variability of gray matter volume in healthy elderly subjects.</description><subject>Adult. Elderly</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Cognition</subject><subject>Cognition - physiology</subject><subject>Cognitive Processes</subject><subject>Cognitive Tests</subject><subject>Comparative Analysis</subject><subject>Correlation</subject><subject>Developmental psychology</subject><subject>Digit Span Test (Case and Kurland)</subject><subject>Elderly</subject><subject>Evaluation Methods</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gray matter</subject><subject>Health</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Neuropsychological Tests</subject><subject>Older Adults</subject><subject>Organ Size</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Science Education</subject><subject>Scientific Concepts</subject><subject>Semantic memory</subject><subject>Semantics</subject><subject>Semiotics</subject><subject>Short Term Memory</subject><subject>Visual Stimuli</subject><subject>Wechsler Adult Intelligence Scale (Revised)</subject><subject>White matter</subject><issn>0278-2626</issn><issn>1090-2147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhi0EoqHlF4DQXhCnTT32ftgHDigq0KoSl_Zsee3ZxpF3HWynVf49ThPKjZOleZ8Zj54h5APQJVDoLjfLQc_WLBk9VGBJqXhFFkAlrRk0_WuyoKwXNetYd0bepbShlMqGsbfkjAFwAAYLcrcKMaLX2YW5GjA_Ic7VQ9T7y6e1y1hNOmeM1WPwuwmr8l9lwsPsnnE3V2vUPq_3FXqL0e-rLYatxwvyZtQ-4fvTe07uv1_drX7Wt79-XK--3dam6dtcjwJgkIy1KBlYyRsz9J3oW2g4Ra21ZNxyDdBbPlotpNCNbu2AtqFi4O3Az8mX49xtDL93mLKaXDLovZ4x7JISjehE10soJD-SJoaUIo5qG92k414BVQebaqOebaqDTQWgis3S9ek0fzdMaF96_uorwOcToJPRfox6Ni7947hkfTlI4T4eOYzOvMRXN2WzcqkSfz3FRdajw6iScTgbtC6iycoG9989_wD3zp0X</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Taki, Yasuyuki</creator><creator>Kinomura, Shigeo</creator><creator>Sato, Kazunori</creator><creator>Goto, Ryoi</creator><creator>Wu, Kai</creator><creator>Kawashima, Ryuta</creator><creator>Fukuda, Hiroshi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>Correlation between gray/white matter volume and cognition in healthy elderly people</title><author>Taki, Yasuyuki ; Kinomura, Shigeo ; Sato, Kazunori ; Goto, Ryoi ; Wu, Kai ; Kawashima, Ryuta ; Fukuda, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-f811b9225e921d934cb768751430eaaa923d3a117d3fda898a4a5dbed408b35b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult. Elderly</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Cognition</topic><topic>Cognition - physiology</topic><topic>Cognitive Processes</topic><topic>Cognitive Tests</topic><topic>Comparative Analysis</topic><topic>Correlation</topic><topic>Developmental psychology</topic><topic>Digit Span Test (Case and Kurland)</topic><topic>Elderly</topic><topic>Evaluation Methods</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gray matter</topic><topic>Health</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Neuropsychological Tests</topic><topic>Older Adults</topic><topic>Organ Size</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Science Education</topic><topic>Scientific Concepts</topic><topic>Semantic memory</topic><topic>Semantics</topic><topic>Semiotics</topic><topic>Short Term Memory</topic><topic>Visual Stimuli</topic><topic>Wechsler Adult Intelligence Scale (Revised)</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taki, Yasuyuki</creatorcontrib><creatorcontrib>Kinomura, Shigeo</creatorcontrib><creatorcontrib>Sato, Kazunori</creatorcontrib><creatorcontrib>Goto, Ryoi</creatorcontrib><creatorcontrib>Wu, Kai</creatorcontrib><creatorcontrib>Kawashima, Ryuta</creatorcontrib><creatorcontrib>Fukuda, Hiroshi</creatorcontrib><collection>ERIC</collection><collection>ERIC (Ovid)</collection><collection>ERIC</collection><collection>ERIC</collection><collection>ERIC (Legacy Platform)</collection><collection>ERIC( SilverPlatter )</collection><collection>ERIC</collection><collection>ERIC PlusText (Legacy Platform)</collection><collection>Education Resources Information Center (ERIC)</collection><collection>ERIC</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain and cognition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taki, Yasuyuki</au><au>Kinomura, Shigeo</au><au>Sato, Kazunori</au><au>Goto, Ryoi</au><au>Wu, Kai</au><au>Kawashima, Ryuta</au><au>Fukuda, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ913147</ericid><atitle>Correlation between gray/white matter volume and cognition in healthy elderly people</atitle><jtitle>Brain and cognition</jtitle><addtitle>Brain Cogn</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>75</volume><issue>2</issue><spage>170</spage><epage>176</epage><pages>170-176</pages><issn>0278-2626</issn><eissn>1090-2147</eissn><coden>BRCOEI</coden><abstract>This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109 community-dwelling healthy elderly individuals. We used the Information and Digit Span subtests of the Wechsler Adult Intelligent Scale-Revised as measures of semantic memory and short-term memory, respectively. We found significant positive correlations between the gray matter ratio, the percentage of gray matter volume in the intracranial volume, and performance on the Digit Span subtest, and between the regional gray matter volumes of the bilateral anterior temporal lobes and performance on the Information subtest. No significant correlations between performance on the cognitive tests and white matter volume were found. Our results suggest that individual variability in specific cognitive functions that are relatively well preserved with aging is accounted for by the variability of gray matter volume in healthy elderly subjects.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21131121</pmid><doi>10.1016/j.bandc.2010.11.008</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-2626 |
| ispartof | Brain and cognition, 2011-03, Vol.75 (2), p.170-176 |
| issn | 0278-2626 1090-2147 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_848686791 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult. Elderly Aged Aging Aging - physiology Biological and medical sciences Brain Brain - anatomy & histology Brain - physiology Brain Mapping Cognition Cognition - physiology Cognitive Processes Cognitive Tests Comparative Analysis Correlation Developmental psychology Digit Span Test (Case and Kurland) Elderly Evaluation Methods Female Fundamental and applied biological sciences. Psychology Gray matter Health Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Memory - physiology Neuropsychological Tests Older Adults Organ Size Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Science Education Scientific Concepts Semantic memory Semantics Semiotics Short Term Memory Visual Stimuli Wechsler Adult Intelligence Scale (Revised) White matter |
| title | Correlation between gray/white matter volume and cognition in healthy elderly people |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T12%3A07%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20between%20gray/white%20matter%20volume%20and%20cognition%20in%20healthy%20elderly%20people&rft.jtitle=Brain%20and%20cognition&rft.au=Taki,%20Yasuyuki&rft.date=2011-03-01&rft.volume=75&rft.issue=2&rft.spage=170&rft.epage=176&rft.pages=170-176&rft.issn=0278-2626&rft.eissn=1090-2147&rft.coden=BRCOEI&rft_id=info:doi/10.1016/j.bandc.2010.11.008&rft_dat=%3Cproquest_cross%3E848686791%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=848686791&rft_id=info:pmid/21131121&rft_ericid=EJ913147&rft_els_id=S0278262610001636&rfr_iscdi=true |