Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion
► HDAC inhibitors strongly inhibit the migration and invasion of prostate cancer cells through the up-regulation of E-cadherin. ► Specific downregulation of HDAC1 leads to an increase in E-cadherin expression and subsequent inhibition of cell motility and invasion. ► HDAC1 is a major repressive enzy...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2011-01, Vol.404 (4), p.915-921 |
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| creator | Kim, Nam Hyun Kim, Su-Nam Kim, Yong Kee |
| description | ► HDAC inhibitors strongly inhibit the migration and invasion of prostate cancer cells through the up-regulation of E-cadherin. ► Specific downregulation of HDAC1 leads to an increase in E-cadherin expression and subsequent inhibition of cell motility and invasion. ► HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness.
In this study, we investigate the molecular mechanism by which histone deacetylase (HDAC) inhibitors exert anti-invasiveness effect against prostate cancer cells. We first evaluate the growth inhibition effect of HDAC inhibitors in prostate cancer cells, which is accompanied by induction of p21
WAF1 expression and accumulation of acetylated histones. And we found that the migration and invasion of prostate cancer cells is strongly inhibited by treatment with HDAC inhibitors. In parallel, E-cadherin level is highly up-regulated in HDAC inhibitor-treated prostate cancer cells. And siRNA knockdown of E-cadherin significantly diminishes the anti-invasion effect of HDAC inhibitors, indicating that E-cadherin overexpression is one of possible mechanism for anti-invasion effect of HDAC inhibitors. Furthermore, specific downregulation of HDAC1, but not HDAC2, causes E-cadherin expression and subsequent inhibition of cell motility and invasion. Collectively, our data demonstrate that HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness. |
| doi_str_mv | 10.1016/j.bbrc.2010.12.081 |
| format | Article |
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In this study, we investigate the molecular mechanism by which histone deacetylase (HDAC) inhibitors exert anti-invasiveness effect against prostate cancer cells. We first evaluate the growth inhibition effect of HDAC inhibitors in prostate cancer cells, which is accompanied by induction of p21
WAF1 expression and accumulation of acetylated histones. And we found that the migration and invasion of prostate cancer cells is strongly inhibited by treatment with HDAC inhibitors. In parallel, E-cadherin level is highly up-regulated in HDAC inhibitor-treated prostate cancer cells. And siRNA knockdown of E-cadherin significantly diminishes the anti-invasion effect of HDAC inhibitors, indicating that E-cadherin overexpression is one of possible mechanism for anti-invasion effect of HDAC inhibitors. Furthermore, specific downregulation of HDAC1, but not HDAC2, causes E-cadherin expression and subsequent inhibition of cell motility and invasion. Collectively, our data demonstrate that HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2010.12.081</identifier><identifier>PMID: 21184735</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antineoplastic Agents - pharmacology ; Cadherins - antagonists & inhibitors ; Cadherins - biosynthesis ; Cadherins - genetics ; Cell Line, Tumor ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis ; Cyclin-Dependent Kinase Inhibitor p21 - genetics ; E-cadherin ; Gene Expression Regulation ; Histone Deacetylase 1 - antagonists & inhibitors ; Histone Deacetylase 1 - genetics ; Histone Deacetylase 1 - metabolism ; Histone deacetylase inhibitors ; Histone Deacetylase Inhibitors - pharmacology ; Humans ; Invasion ; Male ; Motility ; Neoplasm Invasiveness ; Prostatic Neoplasms - enzymology ; Prostatic Neoplasms - pathology ; RNA, Small Interfering - genetics</subject><ispartof>Biochemical and biophysical research communications, 2011-01, Vol.404 (4), p.915-921</ispartof><rights>2010 Elsevier Inc.</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-8db925c8aecad9209218c685afc5289c46e5a41c7be890f4c32b5d7dc200a3ed3</citedby><cites>FETCH-LOGICAL-c421t-8db925c8aecad9209218c685afc5289c46e5a41c7be890f4c32b5d7dc200a3ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2010.12.081$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21184735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Nam Hyun</creatorcontrib><creatorcontrib>Kim, Su-Nam</creatorcontrib><creatorcontrib>Kim, Yong Kee</creatorcontrib><title>Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>► HDAC inhibitors strongly inhibit the migration and invasion of prostate cancer cells through the up-regulation of E-cadherin. ► Specific downregulation of HDAC1 leads to an increase in E-cadherin expression and subsequent inhibition of cell motility and invasion. ► HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness.
In this study, we investigate the molecular mechanism by which histone deacetylase (HDAC) inhibitors exert anti-invasiveness effect against prostate cancer cells. We first evaluate the growth inhibition effect of HDAC inhibitors in prostate cancer cells, which is accompanied by induction of p21
WAF1 expression and accumulation of acetylated histones. And we found that the migration and invasion of prostate cancer cells is strongly inhibited by treatment with HDAC inhibitors. In parallel, E-cadherin level is highly up-regulated in HDAC inhibitor-treated prostate cancer cells. And siRNA knockdown of E-cadherin significantly diminishes the anti-invasion effect of HDAC inhibitors, indicating that E-cadherin overexpression is one of possible mechanism for anti-invasion effect of HDAC inhibitors. Furthermore, specific downregulation of HDAC1, but not HDAC2, causes E-cadherin expression and subsequent inhibition of cell motility and invasion. Collectively, our data demonstrate that HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness.</description><subject>Antineoplastic Agents - pharmacology</subject><subject>Cadherins - antagonists & inhibitors</subject><subject>Cadherins - biosynthesis</subject><subject>Cadherins - genetics</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - genetics</subject><subject>E-cadherin</subject><subject>Gene Expression Regulation</subject><subject>Histone Deacetylase 1 - antagonists & inhibitors</subject><subject>Histone Deacetylase 1 - genetics</subject><subject>Histone Deacetylase 1 - metabolism</subject><subject>Histone deacetylase inhibitors</subject><subject>Histone Deacetylase Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Invasion</subject><subject>Male</subject><subject>Motility</subject><subject>Neoplasm Invasiveness</subject><subject>Prostatic Neoplasms - enzymology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>RNA, Small Interfering - genetics</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9P3DAQxS1EBVvgC_SAfOOU7djrZB3BBW0pICH10kq9Wc54onqVP4vtjeDb19ECR04eed57evNj7JuApQBRfd8umybgUsL8IZegxRFbCKihkALUMVsAQFXIWvw9ZV9j3AIIoar6hJ1KIbRar8oFmx6Haewm6mlIfGz5w4_bjeB-4HcFWvePQh7pZRcoRj8O82IXxphsIo52QAocqeviNfcpct_vOo82zcp2PKx4Pybf-fTK7eCyf7Jz0Dn70tou0sXbe8b-_Lz7vXkonn7dP25unwpUUqRCu6aWJWpLuUwtoZZCY6VL22IpdY2qotIqgeuGdA2twpVsSrd2KAHsitzqjF0dcnPr5z3FZHof51p2oHEfjVa60hVolZXyoMR8XwzUml3wvQ2vRoCZcZutmXGbGbcR0mTc2XT5Fr9venIflne-WXBzEFA-cvIUTERPmZvzgTAZN_rP8v8Dh1GScw</recordid><startdate>20110128</startdate><enddate>20110128</enddate><creator>Kim, Nam Hyun</creator><creator>Kim, Su-Nam</creator><creator>Kim, Yong Kee</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110128</creationdate><title>Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion</title><author>Kim, Nam Hyun ; Kim, Su-Nam ; Kim, Yong Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-8db925c8aecad9209218c685afc5289c46e5a41c7be890f4c32b5d7dc200a3ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antineoplastic Agents - pharmacology</topic><topic>Cadherins - antagonists & inhibitors</topic><topic>Cadherins - biosynthesis</topic><topic>Cadherins - genetics</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - genetics</topic><topic>E-cadherin</topic><topic>Gene Expression Regulation</topic><topic>Histone Deacetylase 1 - antagonists & inhibitors</topic><topic>Histone Deacetylase 1 - genetics</topic><topic>Histone Deacetylase 1 - metabolism</topic><topic>Histone deacetylase inhibitors</topic><topic>Histone Deacetylase Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Invasion</topic><topic>Male</topic><topic>Motility</topic><topic>Neoplasm Invasiveness</topic><topic>Prostatic Neoplasms - enzymology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>RNA, Small Interfering - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Nam Hyun</creatorcontrib><creatorcontrib>Kim, Su-Nam</creatorcontrib><creatorcontrib>Kim, Yong Kee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Nam Hyun</au><au>Kim, Su-Nam</au><au>Kim, Yong Kee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2011-01-28</date><risdate>2011</risdate><volume>404</volume><issue>4</issue><spage>915</spage><epage>921</epage><pages>915-921</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>► HDAC inhibitors strongly inhibit the migration and invasion of prostate cancer cells through the up-regulation of E-cadherin. ► Specific downregulation of HDAC1 leads to an increase in E-cadherin expression and subsequent inhibition of cell motility and invasion. ► HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness.
In this study, we investigate the molecular mechanism by which histone deacetylase (HDAC) inhibitors exert anti-invasiveness effect against prostate cancer cells. We first evaluate the growth inhibition effect of HDAC inhibitors in prostate cancer cells, which is accompanied by induction of p21
WAF1 expression and accumulation of acetylated histones. And we found that the migration and invasion of prostate cancer cells is strongly inhibited by treatment with HDAC inhibitors. In parallel, E-cadherin level is highly up-regulated in HDAC inhibitor-treated prostate cancer cells. And siRNA knockdown of E-cadherin significantly diminishes the anti-invasion effect of HDAC inhibitors, indicating that E-cadherin overexpression is one of possible mechanism for anti-invasion effect of HDAC inhibitors. Furthermore, specific downregulation of HDAC1, but not HDAC2, causes E-cadherin expression and subsequent inhibition of cell motility and invasion. Collectively, our data demonstrate that HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21184735</pmid><doi>10.1016/j.bbrc.2010.12.081</doi><tpages>7</tpages></addata></record> |
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| subjects | Antineoplastic Agents - pharmacology Cadherins - antagonists & inhibitors Cadherins - biosynthesis Cadherins - genetics Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics E-cadherin Gene Expression Regulation Histone Deacetylase 1 - antagonists & inhibitors Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone deacetylase inhibitors Histone Deacetylase Inhibitors - pharmacology Humans Invasion Male Motility Neoplasm Invasiveness Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology RNA, Small Interfering - genetics |
| title | Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion |
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