Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels

Abstract Excessive adventitial neovascularization is one of the hallmarks of atherosclerotic plaque progression and is associated with an increased plaque burden by facilitating leukocyte influx and perivascular inflammation. Statins act atheroprotective by reducing plasma cholesterol levels and by...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Atherosclerosis 2011-02, Vol.214 (2), p.295-300
Hauptverfasser:	Bot, Ilze, Jukema, J. Wouter, Lankhuizen, Inge M, van Berkel, Theo J.C, Biessen, Erik A.L
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Angiogenesis Inhibitors - pharmacology Animals Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - blood Atherosclerosis - genetics Atherosclerosis - pathology Atherosclerosis - prevention & control Atorvastatin Calcium Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular carotid arteries Cell Line Cell Proliferation - drug effects Cholesterol Cholesterol - blood Connective Tissue - blood supply Coronary heart disease diet Disease Models, Animal Endothelial cell Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Heart Heptanoic Acids - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology inflammation Male Medical sciences Mice Mice, Knockout Microvessels - drug effects Microvessels - metabolism Microvessels - pathology Neovascularization Neovascularization, Pathologic - blood Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Platelet Endothelial Cell Adhesion Molecule-1 - metabolism protective effect Pyrroles - pharmacology Statins Time Factors weight gain
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!