Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy
Background: Smoking adversely affects the course and severity of Graves' orbitopathy (GO). Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients. Methods: This was...
Gespeichert in:
| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2011-02, Vol.21 (2), p.177-181 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 181 |
|---|---|
| container_issue | 2 |
| container_start_page | 177 |
| container_title | Thyroid (New York, N.Y.) |
| container_volume | 21 |
| creator | Regensburg, Noortje I. Wiersinga, Wilmar M. Berendschot, Tos T.J.M. Saeed, Peerooz Mourits, Maarten P. |
| description | Background:
Smoking adversely affects the course and severity of Graves' orbitopathy (GO). Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients.
Methods:
This was an observational case series study. In 95 consecutive patients with untreated GO, the ratios of fat volume/orbital volume (FV/OV) and muscle volume/OV (MV/OV) were calculated with validated software. The most affected orbit of each patient was chosen for analysis. Patients were divided into two groups based on smoking behavior. One group was current smokers (Sm+) and the other were those who never smoked or those who had not smoked for at least 1 year (Sm−). Patients were grouped in tertiles of FV/OV and MV/OV and contrast in OVs between the Sm+ and Sm− group. The main characteristics of GO were analyzed using Jonckheere-Terpstra trend analysis and Mann–Whitney
U
-test.
Results:
The proportion of current smokers was not different in GO patients when divided in tertiles according to their FV/OV. In contrast, analysis of MV/OV tertiles showed a trend to a higher prevalence of current smokers in patients with larger MVs. Smoking did not influence FV, but the Sm+ group had significantly larger MVs than the Sm− group.
Conclusion:
Smoking is associated with an increase in extraocular MV in untreated patients with GO and not with an increase in FV. |
| doi_str_mv | 10.1089/thy.2010.0218 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_848685054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A249685179</galeid><sourcerecordid>A249685179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-fb5de9e9c0757534978b7cd1ac395650240bc98a0793616bf21892d02f3d05183</originalsourceid><addsrcrecordid>eNqFkc1LHjEQh0NpqfraY68S6MHTvp1kN5vkKOIXWDxUvYZsNtHobvI22RX8782ytlAolDnMZHjmI_ND6CuBLQEhv0-Pr1sK5QWUiA9onzDGKwmcfywxMKg4Ze0eOsj5CYC0gtef0R4lpKGC8H10deacNROODv8c47MPDzgGfJM6P-kBn-sJ69DjH3M2g8X3cZhHi33AF0m_2Hy8gnGnyxaH6JPTQ7Zf3v0G3Z2f3Z5eVtc3F1enJ9eVaaCeKtex3korDXDGWd1ILjpueqJNLVnLgDbQGSk0cFm3pO1c-ZakPVBX98CIqDfoeO27S_HXbPOkRp-NHQYdbJyzEo1oBQPWFPLbSj7owSofXJySNgutTmgjC0XKkA3a_oMq1tvRmxis8yX_V0G1FpgUc07WqV3yo06vioBaNFHlGmrRRC2aFP7ofeG5G23_h_4tQgHqFVjSOoTB286m6T9t3wCYB5T9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>848685054</pqid></control><display><type>article</type><title>Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Regensburg, Noortje I. ; Wiersinga, Wilmar M. ; Berendschot, Tos T.J.M. ; Saeed, Peerooz ; Mourits, Maarten P.</creator><creatorcontrib>Regensburg, Noortje I. ; Wiersinga, Wilmar M. ; Berendschot, Tos T.J.M. ; Saeed, Peerooz ; Mourits, Maarten P.</creatorcontrib><description>Background:
Smoking adversely affects the course and severity of Graves' orbitopathy (GO). Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients.
Methods:
This was an observational case series study. In 95 consecutive patients with untreated GO, the ratios of fat volume/orbital volume (FV/OV) and muscle volume/OV (MV/OV) were calculated with validated software. The most affected orbit of each patient was chosen for analysis. Patients were divided into two groups based on smoking behavior. One group was current smokers (Sm+) and the other were those who never smoked or those who had not smoked for at least 1 year (Sm−). Patients were grouped in tertiles of FV/OV and MV/OV and contrast in OVs between the Sm+ and Sm− group. The main characteristics of GO were analyzed using Jonckheere-Terpstra trend analysis and Mann–Whitney
U
-test.
Results:
The proportion of current smokers was not different in GO patients when divided in tertiles according to their FV/OV. In contrast, analysis of MV/OV tertiles showed a trend to a higher prevalence of current smokers in patients with larger MVs. Smoking did not influence FV, but the Sm+ group had significantly larger MVs than the Sm− group.
Conclusion:
Smoking is associated with an increase in extraocular MV in untreated patients with GO and not with an increase in FV.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/thy.2010.0218</identifier><identifier>PMID: 21142817</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adipose tissues ; Adult ; Body Fat Distribution ; Case-Control Studies ; Data Interpretation, Statistical ; Development and progression ; Fibroblasts ; Graves Ophthalmopathy - pathology ; Graves Ophthalmopathy - physiopathology ; Health aspects ; Humans ; Hypoxia - complications ; Hypoxia - etiology ; Hypoxia - pathology ; Lipid Metabolism - physiology ; Middle Aged ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Orbit - pathology ; Orbit - physiopathology ; Organ Size - physiology ; Physiological aspects ; Risk factors ; Smoking ; Smoking - adverse effects ; Thyroid eye disease</subject><ispartof>Thyroid (New York, N.Y.), 2011-02, Vol.21 (2), p.177-181</ispartof><rights>2011, Mary Ann Liebert, Inc.</rights><rights>COPYRIGHT 2011 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-fb5de9e9c0757534978b7cd1ac395650240bc98a0793616bf21892d02f3d05183</citedby><cites>FETCH-LOGICAL-c403t-fb5de9e9c0757534978b7cd1ac395650240bc98a0793616bf21892d02f3d05183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21142817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regensburg, Noortje I.</creatorcontrib><creatorcontrib>Wiersinga, Wilmar M.</creatorcontrib><creatorcontrib>Berendschot, Tos T.J.M.</creatorcontrib><creatorcontrib>Saeed, Peerooz</creatorcontrib><creatorcontrib>Mourits, Maarten P.</creatorcontrib><title>Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>Background:
Smoking adversely affects the course and severity of Graves' orbitopathy (GO). Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients.
Methods:
This was an observational case series study. In 95 consecutive patients with untreated GO, the ratios of fat volume/orbital volume (FV/OV) and muscle volume/OV (MV/OV) were calculated with validated software. The most affected orbit of each patient was chosen for analysis. Patients were divided into two groups based on smoking behavior. One group was current smokers (Sm+) and the other were those who never smoked or those who had not smoked for at least 1 year (Sm−). Patients were grouped in tertiles of FV/OV and MV/OV and contrast in OVs between the Sm+ and Sm− group. The main characteristics of GO were analyzed using Jonckheere-Terpstra trend analysis and Mann–Whitney
U
-test.
Results:
The proportion of current smokers was not different in GO patients when divided in tertiles according to their FV/OV. In contrast, analysis of MV/OV tertiles showed a trend to a higher prevalence of current smokers in patients with larger MVs. Smoking did not influence FV, but the Sm+ group had significantly larger MVs than the Sm− group.
Conclusion:
Smoking is associated with an increase in extraocular MV in untreated patients with GO and not with an increase in FV.</description><subject>Adipose tissues</subject><subject>Adult</subject><subject>Body Fat Distribution</subject><subject>Case-Control Studies</subject><subject>Data Interpretation, Statistical</subject><subject>Development and progression</subject><subject>Fibroblasts</subject><subject>Graves Ophthalmopathy - pathology</subject><subject>Graves Ophthalmopathy - physiopathology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypoxia - complications</subject><subject>Hypoxia - etiology</subject><subject>Hypoxia - pathology</subject><subject>Lipid Metabolism - physiology</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Orbit - pathology</subject><subject>Orbit - physiopathology</subject><subject>Organ Size - physiology</subject><subject>Physiological aspects</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Thyroid eye disease</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LHjEQh0NpqfraY68S6MHTvp1kN5vkKOIXWDxUvYZsNtHobvI22RX8782ytlAolDnMZHjmI_ND6CuBLQEhv0-Pr1sK5QWUiA9onzDGKwmcfywxMKg4Ze0eOsj5CYC0gtef0R4lpKGC8H10deacNROODv8c47MPDzgGfJM6P-kBn-sJ69DjH3M2g8X3cZhHi33AF0m_2Hy8gnGnyxaH6JPTQ7Zf3v0G3Z2f3Z5eVtc3F1enJ9eVaaCeKtex3korDXDGWd1ILjpueqJNLVnLgDbQGSk0cFm3pO1c-ZakPVBX98CIqDfoeO27S_HXbPOkRp-NHQYdbJyzEo1oBQPWFPLbSj7owSofXJySNgutTmgjC0XKkA3a_oMq1tvRmxis8yX_V0G1FpgUc07WqV3yo06vioBaNFHlGmrRRC2aFP7ofeG5G23_h_4tQgHqFVjSOoTB286m6T9t3wCYB5T9</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Regensburg, Noortje I.</creator><creator>Wiersinga, Wilmar M.</creator><creator>Berendschot, Tos T.J.M.</creator><creator>Saeed, Peerooz</creator><creator>Mourits, Maarten P.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy</title><author>Regensburg, Noortje I. ; Wiersinga, Wilmar M. ; Berendschot, Tos T.J.M. ; Saeed, Peerooz ; Mourits, Maarten P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-fb5de9e9c0757534978b7cd1ac395650240bc98a0793616bf21892d02f3d05183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose tissues</topic><topic>Adult</topic><topic>Body Fat Distribution</topic><topic>Case-Control Studies</topic><topic>Data Interpretation, Statistical</topic><topic>Development and progression</topic><topic>Fibroblasts</topic><topic>Graves Ophthalmopathy - pathology</topic><topic>Graves Ophthalmopathy - physiopathology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypoxia - complications</topic><topic>Hypoxia - etiology</topic><topic>Hypoxia - pathology</topic><topic>Lipid Metabolism - physiology</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Orbit - pathology</topic><topic>Orbit - physiopathology</topic><topic>Organ Size - physiology</topic><topic>Physiological aspects</topic><topic>Risk factors</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Thyroid eye disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regensburg, Noortje I.</creatorcontrib><creatorcontrib>Wiersinga, Wilmar M.</creatorcontrib><creatorcontrib>Berendschot, Tos T.J.M.</creatorcontrib><creatorcontrib>Saeed, Peerooz</creatorcontrib><creatorcontrib>Mourits, Maarten P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thyroid (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regensburg, Noortje I.</au><au>Wiersinga, Wilmar M.</au><au>Berendschot, Tos T.J.M.</au><au>Saeed, Peerooz</au><au>Mourits, Maarten P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy</atitle><jtitle>Thyroid (New York, N.Y.)</jtitle><addtitle>Thyroid</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>21</volume><issue>2</issue><spage>177</spage><epage>181</epage><pages>177-181</pages><issn>1050-7256</issn><eissn>1557-9077</eissn><abstract>Background:
Smoking adversely affects the course and severity of Graves' orbitopathy (GO). Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients.
Methods:
This was an observational case series study. In 95 consecutive patients with untreated GO, the ratios of fat volume/orbital volume (FV/OV) and muscle volume/OV (MV/OV) were calculated with validated software. The most affected orbit of each patient was chosen for analysis. Patients were divided into two groups based on smoking behavior. One group was current smokers (Sm+) and the other were those who never smoked or those who had not smoked for at least 1 year (Sm−). Patients were grouped in tertiles of FV/OV and MV/OV and contrast in OVs between the Sm+ and Sm− group. The main characteristics of GO were analyzed using Jonckheere-Terpstra trend analysis and Mann–Whitney
U
-test.
Results:
The proportion of current smokers was not different in GO patients when divided in tertiles according to their FV/OV. In contrast, analysis of MV/OV tertiles showed a trend to a higher prevalence of current smokers in patients with larger MVs. Smoking did not influence FV, but the Sm+ group had significantly larger MVs than the Sm− group.
Conclusion:
Smoking is associated with an increase in extraocular MV in untreated patients with GO and not with an increase in FV.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>21142817</pmid><doi>10.1089/thy.2010.0218</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1050-7256 |
| ispartof | Thyroid (New York, N.Y.), 2011-02, Vol.21 (2), p.177-181 |
| issn | 1050-7256 1557-9077 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_848685054 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adipose tissues Adult Body Fat Distribution Case-Control Studies Data Interpretation, Statistical Development and progression Fibroblasts Graves Ophthalmopathy - pathology Graves Ophthalmopathy - physiopathology Health aspects Humans Hypoxia - complications Hypoxia - etiology Hypoxia - pathology Lipid Metabolism - physiology Middle Aged Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Orbit - pathology Orbit - physiopathology Organ Size - physiology Physiological aspects Risk factors Smoking Smoking - adverse effects Thyroid eye disease |
| title | Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T03%3A41%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Smoking%20on%20Orbital%20Fat%20and%20Muscle%20Volume%20in%20Graves'%20Orbitopathy&rft.jtitle=Thyroid%20(New%20York,%20N.Y.)&rft.au=Regensburg,%20Noortje%20I.&rft.date=2011-02-01&rft.volume=21&rft.issue=2&rft.spage=177&rft.epage=181&rft.pages=177-181&rft.issn=1050-7256&rft.eissn=1557-9077&rft_id=info:doi/10.1089/thy.2010.0218&rft_dat=%3Cgale_proqu%3EA249685179%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=848685054&rft_id=info:pmid/21142817&rft_galeid=A249685179&rfr_iscdi=true |