Tryptophan metabolism in some intestinal helminthiases
Tryptophan is metabolized to nicotinic acid in man through the formylkynurenine pathway. Disordered metabolism of this amino acid with the accumulation of intermediate metabolites (some of which are carcinogenic) had been encountered in patients with bilharzia. The aim of this work was to investigat...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1968, Vol.62 (2), p.243-250 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| container_volume | 62 |
| creator | Abdel-Tawab, G.A. Saad, A.A. Ibrahim, E.K. Moustafa, M.H. Mousa, A.H. Abdel-Wahab, A.F. Mousa, W. |
| description | Tryptophan is metabolized to nicotinic acid in man through the formylkynurenine pathway. Disordered metabolism of this amino acid with the accumulation of intermediate metabolites (some of which are carcinogenic) had been encountered in patients with bilharzia. The aim of this work was to investigate the possibility that some intestinal helminths—
Ascaris lumbricoides and
Ancylostoma duodenale—may induce disordered tryptophan metabolism in the human host.
Results revealed that infection with either
A. lumbricoides (7 cases), or
A. duodenale (8 cases) induced functional pyridoxine deficiency in the host. This deficiency was evidenced by the accumulation of certain metabolites along the tryptophan-nicotinic-acid pathway. The abnormal pattern encountered in these cases could be partially improved by pyridoxine supplements. Furthermore, this impairment in the reactions leading to the formation of nicotinic acid from its precursor, did not manifest itself by clinical symptoms of pellagra in the host. |
| doi_str_mv | 10.1016/0035-9203(68)90164-8 |
| format | Article |
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Ascaris lumbricoides and
Ancylostoma duodenale—may induce disordered tryptophan metabolism in the human host.
Results revealed that infection with either
A. lumbricoides (7 cases), or
A. duodenale (8 cases) induced functional pyridoxine deficiency in the host. This deficiency was evidenced by the accumulation of certain metabolites along the tryptophan-nicotinic-acid pathway. The abnormal pattern encountered in these cases could be partially improved by pyridoxine supplements. Furthermore, this impairment in the reactions leading to the formation of nicotinic acid from its precursor, did not manifest itself by clinical symptoms of pellagra in the host.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/0035-9203(68)90164-8</identifier><identifier>PMID: 5643172</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aminohippuric Acids - urine ; Ancylostomiasis - metabolism ; Ancylostomiasis - urine ; Ascariasis - metabolism ; Ascariasis - urine ; Humans ; Indican - urine ; Intestinal Diseases, Parasitic - metabolism ; Kynurenic Acid - urine ; Kynurenine - urine ; Male ; ortho-Aminobenzoates - urine ; Tryptophan - metabolism ; Vitamin B 6 Deficiency - etiology ; Xanthurenates - urine</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 1968, Vol.62 (2), p.243-250</ispartof><rights>1968</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-ae4a81ea2df06f8a3e38689320f68a32b820b033887d5e63e220649e2003bc093</citedby><cites>FETCH-LOGICAL-c395t-ae4a81ea2df06f8a3e38689320f68a32b820b033887d5e63e220649e2003bc093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5643172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Tawab, G.A.</creatorcontrib><creatorcontrib>Saad, A.A.</creatorcontrib><creatorcontrib>Ibrahim, E.K.</creatorcontrib><creatorcontrib>Moustafa, M.H.</creatorcontrib><creatorcontrib>Mousa, A.H.</creatorcontrib><creatorcontrib>Abdel-Wahab, A.F.</creatorcontrib><creatorcontrib>Mousa, W.</creatorcontrib><title>Tryptophan metabolism in some intestinal helminthiases</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Tryptophan is metabolized to nicotinic acid in man through the formylkynurenine pathway. Disordered metabolism of this amino acid with the accumulation of intermediate metabolites (some of which are carcinogenic) had been encountered in patients with bilharzia. The aim of this work was to investigate the possibility that some intestinal helminths—
Ascaris lumbricoides and
Ancylostoma duodenale—may induce disordered tryptophan metabolism in the human host.
Results revealed that infection with either
A. lumbricoides (7 cases), or
A. duodenale (8 cases) induced functional pyridoxine deficiency in the host. This deficiency was evidenced by the accumulation of certain metabolites along the tryptophan-nicotinic-acid pathway. The abnormal pattern encountered in these cases could be partially improved by pyridoxine supplements. Furthermore, this impairment in the reactions leading to the formation of nicotinic acid from its precursor, did not manifest itself by clinical symptoms of pellagra in the host.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aminohippuric Acids - urine</subject><subject>Ancylostomiasis - metabolism</subject><subject>Ancylostomiasis - urine</subject><subject>Ascariasis - metabolism</subject><subject>Ascariasis - urine</subject><subject>Humans</subject><subject>Indican - urine</subject><subject>Intestinal Diseases, Parasitic - metabolism</subject><subject>Kynurenic Acid - urine</subject><subject>Kynurenine - urine</subject><subject>Male</subject><subject>ortho-Aminobenzoates - urine</subject><subject>Tryptophan - metabolism</subject><subject>Vitamin B 6 Deficiency - etiology</subject><subject>Xanthurenates - urine</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLA0EQhAdRYnz8A4WcRA-r89iZ7b0IKmrEiAiRiJdhdreXjO4jzmzE_HsnJuToqamu6qb4CDli9JxRpi4oFTJKORWnCs7SsIkj2CJ9BglEQlKxTfqbyC7Z8_6DUi6ZTHukJ1UsWML7RI3dYta1s6lpBjV2Jmsr6-uBbQa-rTHMDn1nG1MNpljVQU6t8egPyE5pKo-H67lPXu9uxzfDaPR8_3BzNYpykcouMhgbYGh4UVJVghEoQEEqOC1VUDwDTjMqBEBSSFQCOacqTpGH4llOU7FPTlZ_Z679mocqurY-x6oyDbZzryEGCUyqEIxXwdy13jss9czZ2riFZlQvceklC71koRXoP1wawtnx-v88q7HYHK35BD9a-dZ3-LOxjfvUKhGJ1MO3dz15pHD9BC96EvKXqzwGKN8Wnfa5xSbHwjrMO1209v9Cv41Nh5o</recordid><startdate>1968</startdate><enddate>1968</enddate><creator>Abdel-Tawab, G.A.</creator><creator>Saad, A.A.</creator><creator>Ibrahim, E.K.</creator><creator>Moustafa, M.H.</creator><creator>Mousa, A.H.</creator><creator>Abdel-Wahab, A.F.</creator><creator>Mousa, W.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1968</creationdate><title>Tryptophan metabolism in some intestinal helminthiases</title><author>Abdel-Tawab, G.A. ; Saad, A.A. ; Ibrahim, E.K. ; Moustafa, M.H. ; Mousa, A.H. ; Abdel-Wahab, A.F. ; Mousa, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-ae4a81ea2df06f8a3e38689320f68a32b820b033887d5e63e220649e2003bc093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aminohippuric Acids - urine</topic><topic>Ancylostomiasis - metabolism</topic><topic>Ancylostomiasis - urine</topic><topic>Ascariasis - metabolism</topic><topic>Ascariasis - urine</topic><topic>Humans</topic><topic>Indican - urine</topic><topic>Intestinal Diseases, Parasitic - metabolism</topic><topic>Kynurenic Acid - urine</topic><topic>Kynurenine - urine</topic><topic>Male</topic><topic>ortho-Aminobenzoates - urine</topic><topic>Tryptophan - metabolism</topic><topic>Vitamin B 6 Deficiency - etiology</topic><topic>Xanthurenates - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Tawab, G.A.</creatorcontrib><creatorcontrib>Saad, A.A.</creatorcontrib><creatorcontrib>Ibrahim, E.K.</creatorcontrib><creatorcontrib>Moustafa, M.H.</creatorcontrib><creatorcontrib>Mousa, A.H.</creatorcontrib><creatorcontrib>Abdel-Wahab, A.F.</creatorcontrib><creatorcontrib>Mousa, W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Tawab, G.A.</au><au>Saad, A.A.</au><au>Ibrahim, E.K.</au><au>Moustafa, M.H.</au><au>Mousa, A.H.</au><au>Abdel-Wahab, A.F.</au><au>Mousa, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tryptophan metabolism in some intestinal helminthiases</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>1968</date><risdate>1968</risdate><volume>62</volume><issue>2</issue><spage>243</spage><epage>250</epage><pages>243-250</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><abstract>Tryptophan is metabolized to nicotinic acid in man through the formylkynurenine pathway. Disordered metabolism of this amino acid with the accumulation of intermediate metabolites (some of which are carcinogenic) had been encountered in patients with bilharzia. The aim of this work was to investigate the possibility that some intestinal helminths—
Ascaris lumbricoides and
Ancylostoma duodenale—may induce disordered tryptophan metabolism in the human host.
Results revealed that infection with either
A. lumbricoides (7 cases), or
A. duodenale (8 cases) induced functional pyridoxine deficiency in the host. This deficiency was evidenced by the accumulation of certain metabolites along the tryptophan-nicotinic-acid pathway. The abnormal pattern encountered in these cases could be partially improved by pyridoxine supplements. Furthermore, this impairment in the reactions leading to the formation of nicotinic acid from its precursor, did not manifest itself by clinical symptoms of pellagra in the host.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>5643172</pmid><doi>10.1016/0035-9203(68)90164-8</doi><tpages>8</tpages></addata></record> |
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1968, Vol.62 (2), p.243-250 |
| issn | 0035-9203 1878-3503 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aminohippuric Acids - urine Ancylostomiasis - metabolism Ancylostomiasis - urine Ascariasis - metabolism Ascariasis - urine Humans Indican - urine Intestinal Diseases, Parasitic - metabolism Kynurenic Acid - urine Kynurenine - urine Male ortho-Aminobenzoates - urine Tryptophan - metabolism Vitamin B 6 Deficiency - etiology Xanthurenates - urine |
| title | Tryptophan metabolism in some intestinal helminthiases |
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