Inhibition of protein synthesis in ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine
The phenanthroindolizidine alkaloids tylophorine and tylocrebrine and the phenanthroquinolizidine alkaloid cryptopleurine inhibit incorporation of leucine into protein in Ehrlich ascites-tumour cells by 50% at 1 × 10 −6 M, 2 × 10 −7 M, and 2 × 10 −8 M respectively, but do not inhibit incorporation o...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1968-04, Vol.31 (1), p.104-109 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Donaldson, Gail R. Atkinson, M.R. Murray, A.W. |
| description | The phenanthroindolizidine alkaloids tylophorine and tylocrebrine and the phenanthroquinolizidine alkaloid cryptopleurine inhibit incorporation of leucine into protein in Ehrlich ascites-tumour cells by 50% at 1 × 10
−6
M, 2 × 10
−7
M, and 2 × 10
−8
M respectively, but do not inhibit incorporation of uracil into nucleic acids at 10
−5
M. Cryptopleurine inhibits leucine incorporation into protein in a cell-free system from Ehrlich cells, but at 10
−5
M does not inhibit protein synthesis in
Escherichia coli. |
| doi_str_mv | 10.1016/0006-291X(68)90037-5 |
| format | Article |
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−6
M, 2 × 10
−7
M, and 2 × 10
−8
M respectively, but do not inhibit incorporation of uracil into nucleic acids at 10
−5
M. Cryptopleurine inhibits leucine incorporation into protein in a cell-free system from Ehrlich cells, but at 10
−5
M does not inhibit protein synthesis in
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−6
M, 2 × 10
−7
M, and 2 × 10
−8
M respectively, but do not inhibit incorporation of uracil into nucleic acids at 10
−5
M. Cryptopleurine inhibits leucine incorporation into protein in a cell-free system from Ehrlich cells, but at 10
−5
M does not inhibit protein synthesis in
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−6
M, 2 × 10
−7
M, and 2 × 10
−8
M respectively, but do not inhibit incorporation of uracil into nucleic acids at 10
−5
M. Cryptopleurine inhibits leucine incorporation into protein in a cell-free system from Ehrlich cells, but at 10
−5
M does not inhibit protein synthesis in
Escherichia coli.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4869942</pmid><doi>10.1016/0006-291X(68)90037-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1968-04, Vol.31 (1), p.104-109 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alkaloids - pharmacology Animals Bacterial Proteins - biosynthesis Carbon Isotopes Carcinoma, Ehrlich Tumor - metabolism Cell-Free System Depression, Chemical Escherichia coli - metabolism Indolizines - pharmacology Leucine - metabolism Neoplasm Proteins - biosynthesis Nucleotides - biosynthesis Phenanthrenes - pharmacology Quinolizines - pharmacology Uracil - metabolism |
| title | Inhibition of protein synthesis in ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine |
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