The Response of Cobalt-Deficient Lambs to Liver Extract and Vitamin B12

The curative activity of an antipernicious anemia liver extract when injected into cobalt-deficient lambs has been confirmed. Separation of this liver extract into 24 fractions by the counter-current distribution technic concentrated the active principle in fractions 12 to 18 inclusive. There was a...

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Veröffentlicht in:	The Journal of nutrition 1951-07, Vol.44 (3), p.455-464
Hauptverfasser:	Smith, Sedgwick E., Koch, Berl A., Turk, K.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cobalt Liver Liver Extracts Old Medline Sheep Sheep, Domestic Vitamin B 12
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container_end_page	464
container_issue	3
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container_title	The Journal of nutrition
container_volume	44
creator	Smith, Sedgwick E. Koch, Berl A. Turk, K.L.
description	The curative activity of an antipernicious anemia liver extract when injected into cobalt-deficient lambs has been confirmed. Separation of this liver extract into 24 fractions by the counter-current distribution technic concentrated the active principle in fractions 12 to 18 inclusive. There was a high correlation between the vitamin B12 activity of these liver extract fractions and the appetite, weight, and hemoglobin responses in cobalt-deficient lambs, which led to a re-evaluation of the curative effects of pure vitamin B12. When large enough doses, 150 µg or more, of B12 were injected, the cobalt-deficient lambs responded favorably in appetite, body weight, and hemoglobin levels. The presently available data show that vitamin B12 is an important intermediary in cobalt metabolism in sheep.
doi_str_mv	10.1093/jn/44.3.455
format	Article
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Separation of this liver extract into 24 fractions by the counter-current distribution technic concentrated the active principle in fractions 12 to 18 inclusive. There was a high correlation between the vitamin B12 activity of these liver extract fractions and the appetite, weight, and hemoglobin responses in cobalt-deficient lambs, which led to a re-evaluation of the curative effects of pure vitamin B12. When large enough doses, 150 µg or more, of B12 were injected, the cobalt-deficient lambs responded favorably in appetite, body weight, and hemoglobin levels. The presently available data show that vitamin B12 is an important intermediary in cobalt metabolism in sheep.</description><identifier>ISSN: 0022-3166</identifier><identifier>DOI: 10.1093/jn/44.3.455</identifier><identifier>PMID: 14851105</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cobalt ; Liver ; Liver Extracts ; Old Medline ; Sheep ; Sheep, Domestic ; Vitamin B 12</subject><ispartof>The Journal of nutrition, 1951-07, Vol.44 (3), p.455-464</ispartof><rights>1951 American Institute of Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2855-84a257475fc68da3a80cafa74283709ce327e846b65208d34dc0a1d95e3305cc3</citedby><cites>FETCH-LOGICAL-c2855-84a257475fc68da3a80cafa74283709ce327e846b65208d34dc0a1d95e3305cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14851105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Sedgwick E.</creatorcontrib><creatorcontrib>Koch, Berl A.</creatorcontrib><creatorcontrib>Turk, K.L.</creatorcontrib><title>The Response of Cobalt-Deficient Lambs to Liver Extract and Vitamin B12</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The curative activity of an antipernicious anemia liver extract when injected into cobalt-deficient lambs has been confirmed. Separation of this liver extract into 24 fractions by the counter-current distribution technic concentrated the active principle in fractions 12 to 18 inclusive. There was a high correlation between the vitamin B12 activity of these liver extract fractions and the appetite, weight, and hemoglobin responses in cobalt-deficient lambs, which led to a re-evaluation of the curative effects of pure vitamin B12. When large enough doses, 150 µg or more, of B12 were injected, the cobalt-deficient lambs responded favorably in appetite, body weight, and hemoglobin levels. The presently available data show that vitamin B12 is an important intermediary in cobalt metabolism in sheep.</description><subject>Animals</subject><subject>Cobalt</subject><subject>Liver</subject><subject>Liver Extracts</subject><subject>Old Medline</subject><subject>Sheep</subject><subject>Sheep, Domestic</subject><subject>Vitamin B 12</subject><issn>0022-3166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1951</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9LwzAYxvEcFKfTk3fJyYt0y882PeqcUygIMr2GNH2LGWszk2zof2_HBl48vZcPD7xfhK4pmVBS8umqnwox4RMh5Qk6J4SxjNM8H6GLGFeEECpKdYZGVChJKZHnaLH8BPwGceP7CNi3eOZrs07ZI7TOOugTrkxXR5w8rtwOAp5_p2BswqZv8IdLpnM9fqDsEp22Zh3h6njH6P1pvpw9Z9Xr4mV2X2WWKSkzJQyThShka3PVGG4UsaY1hWCKF6S0wFkBSuR1LhlRDReNJYY2pQTOibSWj9HtYXcT_NcWYtKdixbWa9OD30athBKiJHSAdwdog48xQKs3wXUm_GhK9L6VXvVaCM310GrQN8fZbd1B82ePoQYgDwCG53YOgo77PBYaF8Am3Xj37_AvRo92Yg</recordid><startdate>195107</startdate><enddate>195107</enddate><creator>Smith, Sedgwick E.</creator><creator>Koch, Berl A.</creator><creator>Turk, K.L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195107</creationdate><title>The Response of Cobalt-Deficient Lambs to Liver Extract and Vitamin B12</title><author>Smith, Sedgwick E. ; Koch, Berl A. ; Turk, K.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2855-84a257475fc68da3a80cafa74283709ce327e846b65208d34dc0a1d95e3305cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1951</creationdate><topic>Animals</topic><topic>Cobalt</topic><topic>Liver</topic><topic>Liver Extracts</topic><topic>Old Medline</topic><topic>Sheep</topic><topic>Sheep, Domestic</topic><topic>Vitamin B 12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Sedgwick E.</creatorcontrib><creatorcontrib>Koch, Berl A.</creatorcontrib><creatorcontrib>Turk, K.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Sedgwick E.</au><au>Koch, Berl A.</au><au>Turk, K.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Response of Cobalt-Deficient Lambs to Liver Extract and Vitamin B12</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1951-07</date><risdate>1951</risdate><volume>44</volume><issue>3</issue><spage>455</spage><epage>464</epage><pages>455-464</pages><issn>0022-3166</issn><abstract>The curative activity of an antipernicious anemia liver extract when injected into cobalt-deficient lambs has been confirmed. Separation of this liver extract into 24 fractions by the counter-current distribution technic concentrated the active principle in fractions 12 to 18 inclusive. There was a high correlation between the vitamin B12 activity of these liver extract fractions and the appetite, weight, and hemoglobin responses in cobalt-deficient lambs, which led to a re-evaluation of the curative effects of pure vitamin B12. When large enough doses, 150 µg or more, of B12 were injected, the cobalt-deficient lambs responded favorably in appetite, body weight, and hemoglobin levels. The presently available data show that vitamin B12 is an important intermediary in cobalt metabolism in sheep.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14851105</pmid><doi>10.1093/jn/44.3.455</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects	Animals Cobalt Liver Liver Extracts Old Medline Sheep Sheep, Domestic Vitamin B 12
title	The Response of Cobalt-Deficient Lambs to Liver Extract and Vitamin B12
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