Acth in ragweed pollinosis: A histologic, immunologic, and clinical study
1. 1. Nine of 26 ragweed-sensitive patients who received 60 mg. ACTH daily for 4 days showed clinical improvement. 2. 2. None of the 8 patients who received placebo injections were improved. 3. 3. Neither the reagin titer nor skin sensitivity to ragweed pollen were altered by treatment with ACTH for...
Gespeichert in:
| Veröffentlicht in: | The Journal of allergy 1951-01, Vol.22 (4), p.304-313 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 313 |
|---|---|
| container_issue | 4 |
| container_start_page | 304 |
| container_title | The Journal of allergy |
| container_volume | 22 |
| creator | Rappaport, Ben Z. Samter, Max McGrew, Elizabeth A. Orrico, Joseph F. Ehrlich, Norman J. Hartley, Henrietta S. Lazar, Harry Lubin, Jerome J. Scala, Ralph A. |
| description | 1.
1. Nine of 26 ragweed-sensitive patients who received 60 mg. ACTH daily for 4 days showed clinical improvement.
2.
2. None of the 8 patients who received placebo injections were improved.
3.
3. Neither the reagin titer nor skin sensitivity to ragweed pollen were altered by treatment with ACTH for the indicated period.
4.
4. Suggestive evidence was found that there is a correlation between the degree of skin sensitivity, the peripheral eosinophilia, and the tissue eosinophilia.
5.
5. No change in histologic characteristics attributable to the use of ACTH could be demonstrated. Edema and eosinophils in various stages of disintegration were found in pretreatment, posttreatment, and control biopsies. |
| doi_str_mv | 10.1016/0021-8707(51)90031-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_84843390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0021870751900317</els_id><sourcerecordid>84843390</sourcerecordid><originalsourceid>FETCH-LOGICAL-e264t-235e33407f0a9fa70c7ddb45d98caef5708ee527c3369c287bef6ebeb62421ab3</originalsourceid><addsrcrecordid>eNo9kE1LAzEQhnNQbK3-A5GcRMHVyWazyXoQSvGjUPCi55BNZtvIftTNrtJ_79a2noZ5eXiZeQi5YHDHgKX3ADGLlAR5LdhNBsBZJI_I-D8ekdMQPodcZiBOyIglSgDL1JjMp7ZbUV_T1ix_EB1dN2Xp6yb48ECndOVD15TN0ttb6quqrw-LqR21A-itKWnoerc5I8eFKQOe7-eEfDw_vc9eo8Xby3w2XUQYp0kXxVwg5wnIAkxWGAlWOpcnwmXKGiyEBIUoYmk5TzMbK5ljkWKOeRonMTM5n5CrXe-6bb56DJ2ufLBYlqbGpg9aJSrhPIMBvNyDfV6h0-vWV6bd6MPzA_C4A3A499tjq4P1WFt0vkXbadd4zUBvDeutSr1VqQXTf4a15L8bhG5F</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84843390</pqid></control><display><type>article</type><title>Acth in ragweed pollinosis: A histologic, immunologic, and clinical study</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Rappaport, Ben Z. ; Samter, Max ; McGrew, Elizabeth A. ; Orrico, Joseph F. ; Ehrlich, Norman J. ; Hartley, Henrietta S. ; Lazar, Harry ; Lubin, Jerome J. ; Scala, Ralph A.</creator><creatorcontrib>Rappaport, Ben Z. ; Samter, Max ; McGrew, Elizabeth A. ; Orrico, Joseph F. ; Ehrlich, Norman J. ; Hartley, Henrietta S. ; Lazar, Harry ; Lubin, Jerome J. ; Scala, Ralph A.</creatorcontrib><description>1.
1. Nine of 26 ragweed-sensitive patients who received 60 mg. ACTH daily for 4 days showed clinical improvement.
2.
2. None of the 8 patients who received placebo injections were improved.
3.
3. Neither the reagin titer nor skin sensitivity to ragweed pollen were altered by treatment with ACTH for the indicated period.
4.
4. Suggestive evidence was found that there is a correlation between the degree of skin sensitivity, the peripheral eosinophilia, and the tissue eosinophilia.
5.
5. No change in histologic characteristics attributable to the use of ACTH could be demonstrated. Edema and eosinophils in various stages of disintegration were found in pretreatment, posttreatment, and control biopsies.</description><identifier>ISSN: 0021-8707</identifier><identifier>DOI: 10.1016/0021-8707(51)90031-7</identifier><identifier>PMID: 14850198</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenocorticotropic Hormone ; Ambrosia ; Biomedical Research ; Humans ; Old Medline ; Rhinitis, Allergic, Seasonal</subject><ispartof>The Journal of allergy, 1951-01, Vol.22 (4), p.304-313</ispartof><rights>1951</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14850198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rappaport, Ben Z.</creatorcontrib><creatorcontrib>Samter, Max</creatorcontrib><creatorcontrib>McGrew, Elizabeth A.</creatorcontrib><creatorcontrib>Orrico, Joseph F.</creatorcontrib><creatorcontrib>Ehrlich, Norman J.</creatorcontrib><creatorcontrib>Hartley, Henrietta S.</creatorcontrib><creatorcontrib>Lazar, Harry</creatorcontrib><creatorcontrib>Lubin, Jerome J.</creatorcontrib><creatorcontrib>Scala, Ralph A.</creatorcontrib><title>Acth in ragweed pollinosis: A histologic, immunologic, and clinical study</title><title>The Journal of allergy</title><addtitle>J Allergy</addtitle><description>1.
1. Nine of 26 ragweed-sensitive patients who received 60 mg. ACTH daily for 4 days showed clinical improvement.
2.
2. None of the 8 patients who received placebo injections were improved.
3.
3. Neither the reagin titer nor skin sensitivity to ragweed pollen were altered by treatment with ACTH for the indicated period.
4.
4. Suggestive evidence was found that there is a correlation between the degree of skin sensitivity, the peripheral eosinophilia, and the tissue eosinophilia.
5.
5. No change in histologic characteristics attributable to the use of ACTH could be demonstrated. Edema and eosinophils in various stages of disintegration were found in pretreatment, posttreatment, and control biopsies.</description><subject>Adrenocorticotropic Hormone</subject><subject>Ambrosia</subject><subject>Biomedical Research</subject><subject>Humans</subject><subject>Old Medline</subject><subject>Rhinitis, Allergic, Seasonal</subject><issn>0021-8707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1951</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhnNQbK3-A5GcRMHVyWazyXoQSvGjUPCi55BNZtvIftTNrtJ_79a2noZ5eXiZeQi5YHDHgKX3ADGLlAR5LdhNBsBZJI_I-D8ekdMQPodcZiBOyIglSgDL1JjMp7ZbUV_T1ix_EB1dN2Xp6yb48ECndOVD15TN0ttb6quqrw-LqR21A-itKWnoerc5I8eFKQOe7-eEfDw_vc9eo8Xby3w2XUQYp0kXxVwg5wnIAkxWGAlWOpcnwmXKGiyEBIUoYmk5TzMbK5ljkWKOeRonMTM5n5CrXe-6bb56DJ2ufLBYlqbGpg9aJSrhPIMBvNyDfV6h0-vWV6bd6MPzA_C4A3A499tjq4P1WFt0vkXbadd4zUBvDeutSr1VqQXTf4a15L8bhG5F</recordid><startdate>19510101</startdate><enddate>19510101</enddate><creator>Rappaport, Ben Z.</creator><creator>Samter, Max</creator><creator>McGrew, Elizabeth A.</creator><creator>Orrico, Joseph F.</creator><creator>Ehrlich, Norman J.</creator><creator>Hartley, Henrietta S.</creator><creator>Lazar, Harry</creator><creator>Lubin, Jerome J.</creator><creator>Scala, Ralph A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19510101</creationdate><title>Acth in ragweed pollinosis: A histologic, immunologic, and clinical study</title><author>Rappaport, Ben Z. ; Samter, Max ; McGrew, Elizabeth A. ; Orrico, Joseph F. ; Ehrlich, Norman J. ; Hartley, Henrietta S. ; Lazar, Harry ; Lubin, Jerome J. ; Scala, Ralph A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e264t-235e33407f0a9fa70c7ddb45d98caef5708ee527c3369c287bef6ebeb62421ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1951</creationdate><topic>Adrenocorticotropic Hormone</topic><topic>Ambrosia</topic><topic>Biomedical Research</topic><topic>Humans</topic><topic>Old Medline</topic><topic>Rhinitis, Allergic, Seasonal</topic><toplevel>online_resources</toplevel><creatorcontrib>Rappaport, Ben Z.</creatorcontrib><creatorcontrib>Samter, Max</creatorcontrib><creatorcontrib>McGrew, Elizabeth A.</creatorcontrib><creatorcontrib>Orrico, Joseph F.</creatorcontrib><creatorcontrib>Ehrlich, Norman J.</creatorcontrib><creatorcontrib>Hartley, Henrietta S.</creatorcontrib><creatorcontrib>Lazar, Harry</creatorcontrib><creatorcontrib>Lubin, Jerome J.</creatorcontrib><creatorcontrib>Scala, Ralph A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rappaport, Ben Z.</au><au>Samter, Max</au><au>McGrew, Elizabeth A.</au><au>Orrico, Joseph F.</au><au>Ehrlich, Norman J.</au><au>Hartley, Henrietta S.</au><au>Lazar, Harry</au><au>Lubin, Jerome J.</au><au>Scala, Ralph A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acth in ragweed pollinosis: A histologic, immunologic, and clinical study</atitle><jtitle>The Journal of allergy</jtitle><addtitle>J Allergy</addtitle><date>1951-01-01</date><risdate>1951</risdate><volume>22</volume><issue>4</issue><spage>304</spage><epage>313</epage><pages>304-313</pages><issn>0021-8707</issn><abstract>1.
1. Nine of 26 ragweed-sensitive patients who received 60 mg. ACTH daily for 4 days showed clinical improvement.
2.
2. None of the 8 patients who received placebo injections were improved.
3.
3. Neither the reagin titer nor skin sensitivity to ragweed pollen were altered by treatment with ACTH for the indicated period.
4.
4. Suggestive evidence was found that there is a correlation between the degree of skin sensitivity, the peripheral eosinophilia, and the tissue eosinophilia.
5.
5. No change in histologic characteristics attributable to the use of ACTH could be demonstrated. Edema and eosinophils in various stages of disintegration were found in pretreatment, posttreatment, and control biopsies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14850198</pmid><doi>10.1016/0021-8707(51)90031-7</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8707 |
| ispartof | The Journal of allergy, 1951-01, Vol.22 (4), p.304-313 |
| issn | 0021-8707 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84843390 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenocorticotropic Hormone Ambrosia Biomedical Research Humans Old Medline Rhinitis, Allergic, Seasonal |
| title | Acth in ragweed pollinosis: A histologic, immunologic, and clinical study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T02%3A39%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acth%20in%20ragweed%20pollinosis:%20A%20histologic,%20immunologic,%20and%20clinical%20study&rft.jtitle=The%20Journal%20of%20allergy&rft.au=Rappaport,%20Ben%20Z.&rft.date=1951-01-01&rft.volume=22&rft.issue=4&rft.spage=304&rft.epage=313&rft.pages=304-313&rft.issn=0021-8707&rft_id=info:doi/10.1016/0021-8707(51)90031-7&rft_dat=%3Cproquest_pubme%3E84843390%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84843390&rft_id=info:pmid/14850198&rft_els_id=0021870751900317&rfr_iscdi=true |