Influence of Age, Body Weight, and Sex on Susceptibility of Mice to the Lethal Effects of X-radiation.
Summary and Conclusions (1) The age at which mice are irradiated profoundly alters their resistance to a single exposure of whole body irradiation. Mortality is low after irradiation at 1 and 15 days of age, very high at 30 days, and decreases rapidly with increasing age thereafter. The possible mec...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1951-04, Vol.76 (4), p.729-732 |
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| container_end_page | 732 |
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| container_issue | 4 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 76 |
| creator | Abrams, Herbert L. |
| description | Summary and Conclusions
(1) The age at which mice are irradiated profoundly alters their resistance to a single exposure of whole body irradiation. Mortality is low after irradiation at 1 and 15 days of age, very high at 30 days, and decreases rapidly with increasing age thereafter. The possible mechanisms of this effect are discussed. (2) The response of mice to whole body irradiation is not related to body weight except insofar as weight reflects a particular age range. (3) In general, sex appears to exert no significant influence on the capacity of mice to withstand whole body irradiation. |
| doi_str_mv | 10.3181/00379727-76-18610 |
| format | Article |
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(1) The age at which mice are irradiated profoundly alters their resistance to a single exposure of whole body irradiation. Mortality is low after irradiation at 1 and 15 days of age, very high at 30 days, and decreases rapidly with increasing age thereafter. The possible mechanisms of this effect are discussed. (2) The response of mice to whole body irradiation is not related to body weight except insofar as weight reflects a particular age range. (3) In general, sex appears to exert no significant influence on the capacity of mice to withstand whole body irradiation.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-76-18610</identifier><identifier>PMID: 14844327</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Body Weight ; Body Weights and Measures ; Disease Susceptibility ; Mice ; Old Medline ; X-Rays</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1951-04, Vol.76 (4), p.729-732</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-beb72c4e92b572c7c84d073c54bccd45ebd4ce7eb0b12b159a6a12c55af2eba13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14844327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abrams, Herbert L.</creatorcontrib><title>Influence of Age, Body Weight, and Sex on Susceptibility of Mice to the Lethal Effects of X-radiation.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary and Conclusions
(1) The age at which mice are irradiated profoundly alters their resistance to a single exposure of whole body irradiation. Mortality is low after irradiation at 1 and 15 days of age, very high at 30 days, and decreases rapidly with increasing age thereafter. The possible mechanisms of this effect are discussed. (2) The response of mice to whole body irradiation is not related to body weight except insofar as weight reflects a particular age range. (3) In general, sex appears to exert no significant influence on the capacity of mice to withstand whole body irradiation.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Body Weights and Measures</subject><subject>Disease Susceptibility</subject><subject>Mice</subject><subject>Old Medline</subject><subject>X-Rays</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1951</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9PwzAUxC0EglL4ACzIExMptmPHyQhV-SMVMQCCzbKdl9YojUvsSPTbk9AiNqY33O9O9w6hM0omKc3pFSGpLCSTicwSmmeU7KERFalI0qwo9tFo0JMBOELHIXwQQoVk2SE6ojznPGVyhKqHpqo7aCxgX-HrBVziG19u8Bu4xTJeYt2U-Bm-sG_wcxcsrKMzrnZxM-CPrrdFj-MS8BziUtd4VlVgYxjU96TVpdPR-WZygg4qXQc43d0xer2dvUzvk_nT3cP0ep5YTlhMDBjJLIeCmb6plTbnJZGpFdxYW3IBpuQWJBhiKDNUFDrTlFkhdMXAaJqO0cU2d936zw5CVCvXt65r3YDvgsr7x1kh0h6kW9C2PoQWKrVu3Uq3G0WJGsZVv-MqmamfcXvP-S68Myso_xy7NXtgsgWCXoD68F3b9M_-k_gNbD-B6A</recordid><startdate>195104</startdate><enddate>195104</enddate><creator>Abrams, Herbert L.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195104</creationdate><title>Influence of Age, Body Weight, and Sex on Susceptibility of Mice to the Lethal Effects of X-radiation.</title><author>Abrams, Herbert L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-beb72c4e92b572c7c84d073c54bccd45ebd4ce7eb0b12b159a6a12c55af2eba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1951</creationdate><topic>Animals</topic><topic>Body Weight</topic><topic>Body Weights and Measures</topic><topic>Disease Susceptibility</topic><topic>Mice</topic><topic>Old Medline</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abrams, Herbert L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abrams, Herbert L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Age, Body Weight, and Sex on Susceptibility of Mice to the Lethal Effects of X-radiation.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1951-04</date><risdate>1951</risdate><volume>76</volume><issue>4</issue><spage>729</spage><epage>732</epage><pages>729-732</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary and Conclusions
(1) The age at which mice are irradiated profoundly alters their resistance to a single exposure of whole body irradiation. Mortality is low after irradiation at 1 and 15 days of age, very high at 30 days, and decreases rapidly with increasing age thereafter. The possible mechanisms of this effect are discussed. (2) The response of mice to whole body irradiation is not related to body weight except insofar as weight reflects a particular age range. (3) In general, sex appears to exert no significant influence on the capacity of mice to withstand whole body irradiation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>14844327</pmid><doi>10.3181/00379727-76-18610</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1951-04, Vol.76 (4), p.729-732 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84842953 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Body Weight Body Weights and Measures Disease Susceptibility Mice Old Medline X-Rays |
| title | Influence of Age, Body Weight, and Sex on Susceptibility of Mice to the Lethal Effects of X-radiation. |
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