Persistence of group A streptococci as related to penicillinase-producing staphylococci: Comparison of penicillin V potassium and sodium nafcillin

A total of 278 children with upper respiratory infections and group A beta-hemolytic streptococci on pharyngeal culture were treated for 10 days with either PVP or SN. Twenty-six (9.3 per cent) had serologically similar group A streptococci on reculture 7 to 10 days after cessation of treatment. The...

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Veröffentlicht in:The Journal of pediatrics 1967-07, Vol.71 (1), p.132-137
Hauptverfasser: Markowitz, Milton, Kramer, Irving, Goldstein, Eugene, Perlman, Anthony, Klein, Donald, Kramer, Robert, Blue, M. Larrie, Pelovitz, Goldie, Roseman, Myra
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container_end_page 137
container_issue 1
container_start_page 132
container_title The Journal of pediatrics
container_volume 71
creator Markowitz, Milton
Kramer, Irving
Goldstein, Eugene
Perlman, Anthony
Klein, Donald
Kramer, Robert
Blue, M. Larrie
Pelovitz, Goldie
Roseman, Myra
description A total of 278 children with upper respiratory infections and group A beta-hemolytic streptococci on pharyngeal culture were treated for 10 days with either PVP or SN. Twenty-six (9.3 per cent) had serologically similar group A streptococci on reculture 7 to 10 days after cessation of treatment. There was no significant difference between the two treatment groups in the percentage of patients who continued to harbor streptococci after therapy. Penicillinase-producing staphylococci were isolated from the initial pharyngeal culture in 17 per cent of the patients. No statistically significant correlation was found between the presence of staphylococci initially and the persistence of streptococci on follow-up culture in either of the 2 treatment groups, although the total number of patients with coexisting streptococci and staphylococci was small. These data suggest that while SN is an effective drug for the treatment of streptococcal infections, it is not superior to a standard penicillin preparation such as PVP.
doi_str_mv 10.1016/S0022-3476(67)80245-2
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No statistically significant correlation was found between the presence of staphylococci initially and the persistence of streptococci on follow-up culture in either of the 2 treatment groups, although the total number of patients with coexisting streptococci and staphylococci was small. These data suggest that while SN is an effective drug for the treatment of streptococcal infections, it is not superior to a standard penicillin preparation such as PVP.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Nafcillin - therapeutic use</subject><subject>Penicillin Resistance</subject><subject>Penicillin V - therapeutic use</subject><subject>Penicillinase - biosynthesis</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Staphylococcus - enzymology</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcus pyogenes - isolation &amp; purification</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EKpfCI1TyCsEi4L_YCRtUXfEnVWqlAltrrj0pRkkcbKdSX6NPTNJclSWrGWnON6Mzh5Azzt5xxvX7a8aEqKQy-o02bxsmVF2JJ2THWWsq3Uj5lOweJc_Ji5x_M8ZaxdgJOakZ00qIHbm_wpRDLjg6pLGjNynOEz2nuSScSnTRuUAh04Q9FPS0RDrhGFzo-zBCxmpK0c8ujDcLAtOvu35jPtB9HCZIIcdx3fsPoj_pFAvkHOaBwuhpjn5tR-g2wUvyrIM-46tjPSU_Pn_6vv9aXVx--bY_v6ic1KxUwFrmm1prxQ-gjOFCKQkduM7JuhFgfOeM6PyBOWjrmjvdeMDWaOG4kgcjT8nrbe9i4c-MudghZId9DyPGOdtGNVLrRi_CehO6FHNO2NkphQHSneXMrlnYhyzs-mirjX3IwoqFOzsemA8D-kfq-Pxl_nGb4-LyNmCy2YU1CB8SumJ9DP-58BeaO5y0</recordid><startdate>196707</startdate><enddate>196707</enddate><creator>Markowitz, Milton</creator><creator>Kramer, Irving</creator><creator>Goldstein, Eugene</creator><creator>Perlman, Anthony</creator><creator>Klein, Donald</creator><creator>Kramer, Robert</creator><creator>Blue, M. 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source MEDLINE; Elsevier ScienceDirect Journals
subjects Adolescent
Child
Child, Preschool
Humans
Nafcillin - therapeutic use
Penicillin Resistance
Penicillin V - therapeutic use
Penicillinase - biosynthesis
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - microbiology
Staphylococcus - enzymology
Streptococcal Infections - drug therapy
Streptococcus pyogenes - isolation & purification
title Persistence of group A streptococci as related to penicillinase-producing staphylococci: Comparison of penicillin V potassium and sodium nafcillin
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