Persistence of group A streptococci as related to penicillinase-producing staphylococci: Comparison of penicillin V potassium and sodium nafcillin
A total of 278 children with upper respiratory infections and group A beta-hemolytic streptococci on pharyngeal culture were treated for 10 days with either PVP or SN. Twenty-six (9.3 per cent) had serologically similar group A streptococci on reculture 7 to 10 days after cessation of treatment. The...
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Veröffentlicht in: | The Journal of pediatrics 1967-07, Vol.71 (1), p.132-137 |
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container_title | The Journal of pediatrics |
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creator | Markowitz, Milton Kramer, Irving Goldstein, Eugene Perlman, Anthony Klein, Donald Kramer, Robert Blue, M. Larrie Pelovitz, Goldie Roseman, Myra |
description | A total of 278 children with upper respiratory infections and group A beta-hemolytic streptococci on pharyngeal culture were treated for 10 days with either PVP or SN. Twenty-six (9.3 per cent) had serologically similar group A streptococci on reculture 7 to 10 days after cessation of treatment. There was no significant difference between the two treatment groups in the percentage of patients who continued to harbor streptococci after therapy.
Penicillinase-producing staphylococci were isolated from the initial pharyngeal culture in 17 per cent of the patients. No statistically significant correlation was found between the presence of staphylococci initially and the persistence of streptococci on follow-up culture in either of the 2 treatment groups, although the total number of patients with coexisting streptococci and staphylococci was small. These data suggest that while SN is an effective drug for the treatment of streptococcal infections, it is not superior to a standard penicillin preparation such as PVP. |
doi_str_mv | 10.1016/S0022-3476(67)80245-2 |
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Penicillinase-producing staphylococci were isolated from the initial pharyngeal culture in 17 per cent of the patients. No statistically significant correlation was found between the presence of staphylococci initially and the persistence of streptococci on follow-up culture in either of the 2 treatment groups, although the total number of patients with coexisting streptococci and staphylococci was small. These data suggest that while SN is an effective drug for the treatment of streptococcal infections, it is not superior to a standard penicillin preparation such as PVP.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(67)80245-2</identifier><identifier>PMID: 5006422</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adolescent ; Child ; Child, Preschool ; Humans ; Nafcillin - therapeutic use ; Penicillin Resistance ; Penicillin V - therapeutic use ; Penicillinase - biosynthesis ; Respiratory Tract Infections - drug therapy ; Respiratory Tract Infections - microbiology ; Staphylococcus - enzymology ; Streptococcal Infections - drug therapy ; Streptococcus pyogenes - isolation & purification</subject><ispartof>The Journal of pediatrics, 1967-07, Vol.71 (1), p.132-137</ispartof><rights>1967 The C. V. Mosby Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-a090d856641ba47712443afacfc3582a7dfc72fdb0ca9551c68dae9762c143b73</citedby><cites>FETCH-LOGICAL-c360t-a090d856641ba47712443afacfc3582a7dfc72fdb0ca9551c68dae9762c143b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(67)80245-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5006422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markowitz, Milton</creatorcontrib><creatorcontrib>Kramer, Irving</creatorcontrib><creatorcontrib>Goldstein, Eugene</creatorcontrib><creatorcontrib>Perlman, Anthony</creatorcontrib><creatorcontrib>Klein, Donald</creatorcontrib><creatorcontrib>Kramer, Robert</creatorcontrib><creatorcontrib>Blue, M. Larrie</creatorcontrib><creatorcontrib>Pelovitz, Goldie</creatorcontrib><creatorcontrib>Roseman, Myra</creatorcontrib><title>Persistence of group A streptococci as related to penicillinase-producing staphylococci: Comparison of penicillin V potassium and sodium nafcillin</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>A total of 278 children with upper respiratory infections and group A beta-hemolytic streptococci on pharyngeal culture were treated for 10 days with either PVP or SN. Twenty-six (9.3 per cent) had serologically similar group A streptococci on reculture 7 to 10 days after cessation of treatment. There was no significant difference between the two treatment groups in the percentage of patients who continued to harbor streptococci after therapy.
Penicillinase-producing staphylococci were isolated from the initial pharyngeal culture in 17 per cent of the patients. No statistically significant correlation was found between the presence of staphylococci initially and the persistence of streptococci on follow-up culture in either of the 2 treatment groups, although the total number of patients with coexisting streptococci and staphylococci was small. These data suggest that while SN is an effective drug for the treatment of streptococcal infections, it is not superior to a standard penicillin preparation such as PVP.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Nafcillin - therapeutic use</subject><subject>Penicillin Resistance</subject><subject>Penicillin V - therapeutic use</subject><subject>Penicillinase - biosynthesis</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Staphylococcus - enzymology</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcus pyogenes - isolation & purification</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQhS0EKpfCI1TyCsEi4L_YCRtUXfEnVWqlAltrrj0pRkkcbKdSX6NPTNJclSWrGWnON6Mzh5Azzt5xxvX7a8aEqKQy-o02bxsmVF2JJ2THWWsq3Uj5lOweJc_Ji5x_M8ZaxdgJOakZ00qIHbm_wpRDLjg6pLGjNynOEz2nuSScSnTRuUAh04Q9FPS0RDrhGFzo-zBCxmpK0c8ujDcLAtOvu35jPtB9HCZIIcdx3fsPoj_pFAvkHOaBwuhpjn5tR-g2wUvyrIM-46tjPSU_Pn_6vv9aXVx--bY_v6ic1KxUwFrmm1prxQ-gjOFCKQkduM7JuhFgfOeM6PyBOWjrmjvdeMDWaOG4kgcjT8nrbe9i4c-MudghZId9DyPGOdtGNVLrRi_CehO6FHNO2NkphQHSneXMrlnYhyzs-mirjX3IwoqFOzsemA8D-kfq-Pxl_nGb4-LyNmCy2YU1CB8SumJ9DP-58BeaO5y0</recordid><startdate>196707</startdate><enddate>196707</enddate><creator>Markowitz, Milton</creator><creator>Kramer, Irving</creator><creator>Goldstein, Eugene</creator><creator>Perlman, Anthony</creator><creator>Klein, Donald</creator><creator>Kramer, Robert</creator><creator>Blue, M. Larrie</creator><creator>Pelovitz, Goldie</creator><creator>Roseman, Myra</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196707</creationdate><title>Persistence of group A streptococci as related to penicillinase-producing staphylococci: Comparison of penicillin V potassium and sodium nafcillin</title><author>Markowitz, Milton ; Kramer, Irving ; Goldstein, Eugene ; Perlman, Anthony ; Klein, Donald ; Kramer, Robert ; Blue, M. Larrie ; Pelovitz, Goldie ; Roseman, Myra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-a090d856641ba47712443afacfc3582a7dfc72fdb0ca9551c68dae9762c143b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Humans</topic><topic>Nafcillin - therapeutic use</topic><topic>Penicillin Resistance</topic><topic>Penicillin V - therapeutic use</topic><topic>Penicillinase - biosynthesis</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Staphylococcus - enzymology</topic><topic>Streptococcal Infections - drug therapy</topic><topic>Streptococcus pyogenes - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markowitz, Milton</creatorcontrib><creatorcontrib>Kramer, Irving</creatorcontrib><creatorcontrib>Goldstein, Eugene</creatorcontrib><creatorcontrib>Perlman, Anthony</creatorcontrib><creatorcontrib>Klein, Donald</creatorcontrib><creatorcontrib>Kramer, Robert</creatorcontrib><creatorcontrib>Blue, M. Larrie</creatorcontrib><creatorcontrib>Pelovitz, Goldie</creatorcontrib><creatorcontrib>Roseman, Myra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markowitz, Milton</au><au>Kramer, Irving</au><au>Goldstein, Eugene</au><au>Perlman, Anthony</au><au>Klein, Donald</au><au>Kramer, Robert</au><au>Blue, M. Larrie</au><au>Pelovitz, Goldie</au><au>Roseman, Myra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistence of group A streptococci as related to penicillinase-producing staphylococci: Comparison of penicillin V potassium and sodium nafcillin</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1967-07</date><risdate>1967</risdate><volume>71</volume><issue>1</issue><spage>132</spage><epage>137</epage><pages>132-137</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>A total of 278 children with upper respiratory infections and group A beta-hemolytic streptococci on pharyngeal culture were treated for 10 days with either PVP or SN. Twenty-six (9.3 per cent) had serologically similar group A streptococci on reculture 7 to 10 days after cessation of treatment. There was no significant difference between the two treatment groups in the percentage of patients who continued to harbor streptococci after therapy.
Penicillinase-producing staphylococci were isolated from the initial pharyngeal culture in 17 per cent of the patients. No statistically significant correlation was found between the presence of staphylococci initially and the persistence of streptococci on follow-up culture in either of the 2 treatment groups, although the total number of patients with coexisting streptococci and staphylococci was small. These data suggest that while SN is an effective drug for the treatment of streptococcal infections, it is not superior to a standard penicillin preparation such as PVP.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>5006422</pmid><doi>10.1016/S0022-3476(67)80245-2</doi><tpages>6</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Adolescent Child Child, Preschool Humans Nafcillin - therapeutic use Penicillin Resistance Penicillin V - therapeutic use Penicillinase - biosynthesis Respiratory Tract Infections - drug therapy Respiratory Tract Infections - microbiology Staphylococcus - enzymology Streptococcal Infections - drug therapy Streptococcus pyogenes - isolation & purification |
title | Persistence of group A streptococci as related to penicillinase-producing staphylococci: Comparison of penicillin V potassium and sodium nafcillin |
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