Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis
Background MicroRNAs (miRNAs) have long been established to remain stable in circulation, and dysregulated miRNAs in serum of tumor patients could potentially serve as novel biomarkers. Aims To determine whether certain serum miRNAs could represent potential diagnostic and prognostic biomarkers for...
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| Veröffentlicht in: | Digestive diseases and sciences 2011-02, Vol.56 (2), p.602-609 |
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| container_title | Digestive diseases and sciences |
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| creator | Kong, Xiangyu Du, Yiqi Wang, Guokun Gao, Jun Gong, Yanfang Li, Lei Zhang, Zhuo Zhu, Jiaqi Jing, Qing Qin, Yongwen Li, Zhaoshen |
| description | Background MicroRNAs (miRNAs) have long been established to remain stable in circulation, and dysregulated miRNAs in serum of tumor patients could potentially serve as novel biomarkers. Aims To determine whether certain serum miRNAs could represent potential diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC). Methods About 35 patients diagnosed with PDAC at different stages between August 2007 and January 2009 were enrolled in this study. Sera from 15 chronic pancreatitis (CP) patients and 15 healthy individuals were treated as controls. Quantitative real-time polymerase chain reaction assays specific to mature miRNAs were used to quantify the relative levels of those PDAC-associated serum miRNAs. Results Of the seven miRNAs detected, three were identified as differentially expressed in PDAC and control groups. miR-21 was able to distinguish PDAC patients from CP (p = 0.033) and healthy subjects (p = 0.001), whereas miR-155 and miR-196a were able to differentiate sera with sick pancreas (PDAC/CP) from normal pancreas (p = 0.0002 and 0.010, respectively). Serum miR-196a expression levels in unresectable PDAC (stages III and IV) patients were significantly higher than those in resectable (stages I and II) patients (p = 0.001). Furthermore, serum miR-196a expression level was found to have a potential value in predicting median survival time of PDAC patients (high-level miR-196a, 6.1 months, (95% CI, 4.49-7.72) versus low-level miR-196a, 12.00 months, (95% CI, 5.92-18.08), p = 0.007). Conclusions Serum miR-196a could be a potential noninvasive marker for PDAC prognosis and selection of laparotomy. |
| doi_str_mv | 10.1007/s10620-010-1285-3 |
| format | Article |
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Aims To determine whether certain serum miRNAs could represent potential diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC). Methods About 35 patients diagnosed with PDAC at different stages between August 2007 and January 2009 were enrolled in this study. Sera from 15 chronic pancreatitis (CP) patients and 15 healthy individuals were treated as controls. Quantitative real-time polymerase chain reaction assays specific to mature miRNAs were used to quantify the relative levels of those PDAC-associated serum miRNAs. Results Of the seven miRNAs detected, three were identified as differentially expressed in PDAC and control groups. miR-21 was able to distinguish PDAC patients from CP (p = 0.033) and healthy subjects (p = 0.001), whereas miR-155 and miR-196a were able to differentiate sera with sick pancreas (PDAC/CP) from normal pancreas (p = 0.0002 and 0.010, respectively). Serum miR-196a expression levels in unresectable PDAC (stages III and IV) patients were significantly higher than those in resectable (stages I and II) patients (p = 0.001). Furthermore, serum miR-196a expression level was found to have a potential value in predicting median survival time of PDAC patients (high-level miR-196a, 6.1 months, (95% CI, 4.49-7.72) versus low-level miR-196a, 12.00 months, (95% CI, 5.92-18.08), p = 0.007). Conclusions Serum miR-196a could be a potential noninvasive marker for PDAC prognosis and selection of laparotomy.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-010-1285-3</identifier><identifier>PMID: 20614181</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Adenocarcinoma ; Aged ; Biochemistry ; Biological and medical sciences ; Biomarkers ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Regulation, Neoplastic - physiology ; Health aspects ; Hepatology ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical research ; Medical sciences ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; MicroRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Middle Aged ; Oncology ; Original Article ; Pancreatic cancer ; Pancreatic Neoplasms - metabolism ; Pancreatitis ; Predictive Value of Tests ; Prognosis ; Transplant Surgery ; Tumors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2011-02, Vol.56 (2), p.602-609</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Springer</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-1f5e8d15f691f2d853f36aaef9d00f6a018d3c7625991f9126cb949d0d69b52d3</citedby><cites>FETCH-LOGICAL-c524t-1f5e8d15f691f2d853f36aaef9d00f6a018d3c7625991f9126cb949d0d69b52d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-010-1285-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-010-1285-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23838184$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20614181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Xiangyu</creatorcontrib><creatorcontrib>Du, Yiqi</creatorcontrib><creatorcontrib>Wang, Guokun</creatorcontrib><creatorcontrib>Gao, Jun</creatorcontrib><creatorcontrib>Gong, Yanfang</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><creatorcontrib>Zhang, Zhuo</creatorcontrib><creatorcontrib>Zhu, Jiaqi</creatorcontrib><creatorcontrib>Jing, Qing</creatorcontrib><creatorcontrib>Qin, Yongwen</creatorcontrib><creatorcontrib>Li, Zhaoshen</creatorcontrib><title>Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background MicroRNAs (miRNAs) have long been established to remain stable in circulation, and dysregulated miRNAs in serum of tumor patients could potentially serve as novel biomarkers. Aims To determine whether certain serum miRNAs could represent potential diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC). Methods About 35 patients diagnosed with PDAC at different stages between August 2007 and January 2009 were enrolled in this study. Sera from 15 chronic pancreatitis (CP) patients and 15 healthy individuals were treated as controls. Quantitative real-time polymerase chain reaction assays specific to mature miRNAs were used to quantify the relative levels of those PDAC-associated serum miRNAs. Results Of the seven miRNAs detected, three were identified as differentially expressed in PDAC and control groups. miR-21 was able to distinguish PDAC patients from CP (p = 0.033) and healthy subjects (p = 0.001), whereas miR-155 and miR-196a were able to differentiate sera with sick pancreas (PDAC/CP) from normal pancreas (p = 0.0002 and 0.010, respectively). Serum miR-196a expression levels in unresectable PDAC (stages III and IV) patients were significantly higher than those in resectable (stages I and II) patients (p = 0.001). Furthermore, serum miR-196a expression level was found to have a potential value in predicting median survival time of PDAC patients (high-level miR-196a, 6.1 months, (95% CI, 4.49-7.72) versus low-level miR-196a, 12.00 months, (95% CI, 5.92-18.08), p = 0.007). Conclusions Serum miR-196a could be a potential noninvasive marker for PDAC prognosis and selection of laparotomy.</description><subject>Adenocarcinoma</subject><subject>Aged</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatitis</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Transplant Surgery</subject><subject>Tumors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kttu1DAQhiMEotvCA3ADFgjBTYrHThyHu-1uOUjloJZeR17HXrkk9mInEn0ZnpUJWahAqLJkJ57v_-3xTJY9AnoMlFavElDBaE6B5sBkmfM72QLKiuesFPJutqAg8BtAHGSHKV1RSusKxP3sgFEBBUhYZD_WZjB6cMGTYMnaWWui8YNTXXdNTr_voknJtKR3Oobzj8tEnCcXJo79hH9WXkejBqfJetSD6siyNT5oFbXzoVcIDA7d0ms0OM-hFoqswti15MQQjIZhPop8UPGricSGiJvTFMPWh-TSg-yeVV0yD_frUXb55vTL6l1-9unt-9XyLNclK4YcbGlkC6UVNVjWypJbLpQytm4ptUJRkC3XlWBljUANTOhNXWCwFfWmZC0_yl7MvrsYvo0mDU3vkjZdp7wJY2pkITlIIQskX95KQiEkL4EVE_r0H_QqjNFjHuhXCSwHlwg9m6Gt6kzjvA1DVHrybJYVMLxlIShSx_-hcLQGSxO8sQ73_xLALMC6pRSNbXbR9SpeN0CbqXmauXkaOv1j8zQcNY_39x03vWn_KH53CwLP94BKWnU2Yv1duuEwHQm_3ojNXMKQ35p4k_htpz-ZRVaFRm0jGl9eMAqcQs0FLQv-E0lB4uE</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Kong, Xiangyu</creator><creator>Du, Yiqi</creator><creator>Wang, Guokun</creator><creator>Gao, Jun</creator><creator>Gong, Yanfang</creator><creator>Li, Lei</creator><creator>Zhang, Zhuo</creator><creator>Zhu, Jiaqi</creator><creator>Jing, Qing</creator><creator>Qin, Yongwen</creator><creator>Li, Zhaoshen</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis</title><author>Kong, Xiangyu ; Du, Yiqi ; Wang, Guokun ; Gao, Jun ; Gong, Yanfang ; Li, Lei ; Zhang, Zhuo ; Zhu, Jiaqi ; Jing, Qing ; Qin, Yongwen ; Li, Zhaoshen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-1f5e8d15f691f2d853f36aaef9d00f6a018d3c7625991f9126cb949d0d69b52d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenocarcinoma</topic><topic>Aged</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>MicroRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatitis</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Transplant Surgery</topic><topic>Tumors</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Xiangyu</creatorcontrib><creatorcontrib>Du, Yiqi</creatorcontrib><creatorcontrib>Wang, Guokun</creatorcontrib><creatorcontrib>Gao, Jun</creatorcontrib><creatorcontrib>Gong, Yanfang</creatorcontrib><creatorcontrib>Li, Lei</creatorcontrib><creatorcontrib>Zhang, Zhuo</creatorcontrib><creatorcontrib>Zhu, Jiaqi</creatorcontrib><creatorcontrib>Jing, Qing</creatorcontrib><creatorcontrib>Qin, Yongwen</creatorcontrib><creatorcontrib>Li, Zhaoshen</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Xiangyu</au><au>Du, Yiqi</au><au>Wang, Guokun</au><au>Gao, Jun</au><au>Gong, Yanfang</au><au>Li, Lei</au><au>Zhang, Zhuo</au><au>Zhu, Jiaqi</au><au>Jing, Qing</au><au>Qin, Yongwen</au><au>Li, Zhaoshen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>56</volume><issue>2</issue><spage>602</spage><epage>609</epage><pages>602-609</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background MicroRNAs (miRNAs) have long been established to remain stable in circulation, and dysregulated miRNAs in serum of tumor patients could potentially serve as novel biomarkers. Aims To determine whether certain serum miRNAs could represent potential diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC). Methods About 35 patients diagnosed with PDAC at different stages between August 2007 and January 2009 were enrolled in this study. Sera from 15 chronic pancreatitis (CP) patients and 15 healthy individuals were treated as controls. Quantitative real-time polymerase chain reaction assays specific to mature miRNAs were used to quantify the relative levels of those PDAC-associated serum miRNAs. Results Of the seven miRNAs detected, three were identified as differentially expressed in PDAC and control groups. miR-21 was able to distinguish PDAC patients from CP (p = 0.033) and healthy subjects (p = 0.001), whereas miR-155 and miR-196a were able to differentiate sera with sick pancreas (PDAC/CP) from normal pancreas (p = 0.0002 and 0.010, respectively). Serum miR-196a expression levels in unresectable PDAC (stages III and IV) patients were significantly higher than those in resectable (stages I and II) patients (p = 0.001). Furthermore, serum miR-196a expression level was found to have a potential value in predicting median survival time of PDAC patients (high-level miR-196a, 6.1 months, (95% CI, 4.49-7.72) versus low-level miR-196a, 12.00 months, (95% CI, 5.92-18.08), p = 0.007). Conclusions Serum miR-196a could be a potential noninvasive marker for PDAC prognosis and selection of laparotomy.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>20614181</pmid><doi>10.1007/s10620-010-1285-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma Aged Biochemistry Biological and medical sciences Biomarkers Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic - physiology Health aspects Hepatology Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Oncology Original Article Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatitis Predictive Value of Tests Prognosis Transplant Surgery Tumors Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Detection of Differentially Expressed microRNAs in Serum of Pancreatic Ductal Adenocarcinoma Patients: miR-196a Could Be a Potential Marker for Poor Prognosis |
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