Regulatory dendritic cells program generation of interleukin-4–producing alternative memory CD4 T cells with suppressive activity

The heterogeneity and mechanisms for the generation of CD4 memory T (CD4 Tm) cells remain elusive. Distinct subsets of dendritic cells (DCs) have been found to regulate a distinct T-helper (Th)–cell subset differentiation by influencing cytokine cues around CD4 T cells; however, whether and how the...

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Veröffentlicht in:	Blood 2011-01, Vol.117 (4), p.1218-1227
Hauptverfasser:	Xu, Xiongfei, Guo, Zhenhong, Jiang, Xueyu, Yao, Yushi, Gao, Qiangguo, Ding, Yuanyuan, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - physiology Cell Differentiation - immunology Cell Proliferation Cells, Cultured Dendritic Cells - immunology Dendritic Cells - physiology Flow Cytometry Hematologic and hematopoietic diseases Immune Tolerance - immunology Immunologic Memory - immunology Immunologic Memory - physiology Interleukin-4 - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - physiology
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