The role of stem cell factor and c-KIT in keloid pathogenesis: do tyrosine kinase inhibitors have a potential therapeutic role?

Summary Background Keloids are fibroproliferative disorders characterized by increased deposition of extracellular matrix components. Stem cell factor (SCF) and its receptor c‐KIT are expressed in a wide variety of cells and have also been demonstrated to be important modulators of the wound healin...

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Veröffentlicht in:	British journal of dermatology (1951) 2011-02, Vol.164 (2), p.372-386
Hauptverfasser:	Mukhopadhyay, A., Do, D.V., Ong, C.T., Khoo, Y.T., Masilamani, J., Chan, S.Y., Vincent, A.S., Wong, P.K., Lim, C.P., Cao, X., Lim, I.J., Phan, T.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides Biological and medical sciences Blotting, Western Cell Communication - drug effects Cells, Cultured Coculture Techniques Dermatology Fibroblasts - drug effects Fibroblasts - metabolism Humans Imatinib Mesylate Immunohistochemistry Keloid - drug therapy Keloid - etiology Keloid - metabolism Medical sciences Piperazines - pharmacology Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-kit - drug effects Proto-Oncogene Proteins c-kit - metabolism Pyrimidines - pharmacology Skin - metabolism Skin involvement in other diseases. Miscellaneous. General aspects Stem Cell Factor - drug effects Stem Cell Factor - metabolism Up-Regulation
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