Autoantigen‐specific regulatory T cells, a potential tool for immune‐tolerance reconstitution in type‐2 autoimmune hepatitis

Effector CD4 and CD8 T cell immune responses to cytochrome P450IID6 (CYP2D6), the autoantigen of autoimmune hepatitis type 2 (AIH‐2), are permitted by a numerical and functional impairment of CD4posCD25high regulatory T cells (T‐regs). We aimed to investigate whether T‐regs specific for CYP2D6 immun...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2011-02, Vol.53 (2), p.536-547
Hauptverfasser:	Longhi, Maria Serena, Hussain, Munther J., Kwok, William W., Mieli‐Vergani, Giorgina, Ma, Yun, Vergani, Diego
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antigens Autoantibodies - metabolism Autoantigens - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - physiology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - physiology Cell growth Cell Proliferation Cells, Cultured Child Child, Preschool Cytochrome P-450 CYP2D6 - immunology Cytokines Cytokines - metabolism Cytotoxicity Dendritic Cells - immunology Dendritic Cells - pathology Dendritic Cells - physiology Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis, Autoimmune - immunology Hepatitis, Autoimmune - physiopathology Hepatitis, Autoimmune - therapy Hepatology HLA-DR7 Antigen - metabolism Humans Immune Tolerance - immunology Immunotherapy Infant Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphocytes Male Medical sciences Other diseases. Semiology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - physiology Young Adult
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