Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets

A variety of human disorders, e.g., ischemic heart disease, stroke, kidney disease, eventually share the deleterious consequences of a common, hypoxic and oxidative stress pathway. In this review, we utilize recent information on the cellular defense mechanisms against hypoxia and oxidative stress w...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2011-02, Vol.300 (2), p.C226-C231
Hauptverfasser:	Miyata, Toshio, Takizawa, Shunya, van Ypersele de Strihou, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inducing Agents - therapeutic use Animals Erythrocytes Genes Humans Hypoxia Hypoxia - drug therapy Hypoxia - physiopathology Hypoxia-Inducible Factor 1 - metabolism Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - metabolism Kelch-Like ECH-Associated Protein 1 Medical treatment Mice Mitochondria - metabolism Mitochondria - physiology NF-E2-Related Factor 2 - agonists NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidation Oxidative Stress - drug effects Oxidative Stress - physiology Oxygen Oxygen - metabolism Procollagen-Proline Dioxygenase - antagonists & inhibitors Protease Inhibitors - therapeutic use Rats
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