Lysosomal Stability during Phagocytosis of Aspergillus flavus Spores by Alveolar Macrophages of Cortisone-Treated Mice
Control mice and those treated with cortisone were exposed to aerosols of viable spores of Aspergillus flavus. Fifteen to 20 minutes later, animals were killed, and alveolar macrophages were obtained by tracheobronchial lavage. Electron-microscopic examination of these cells revealed that, whereas t...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1968-04, Vol.160 (3823), p.79-81 |
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| container_issue | 3823 |
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| creator | Merkow, Leonard Pardo, Matias Epstein, Sheldon M. Verney, Ethel Sidransky, Herschel |
| description | Control mice and those treated with cortisone were exposed to aerosols of viable spores of Aspergillus flavus. Fifteen to 20 minutes later, animals were killed, and alveolar macrophages were obtained by tracheobronchial lavage. Electron-microscopic examination of these cells revealed that, whereas the lysosomes of control macrophages showed extensive attraction and fusion with the phagocytic membranes surrounding spores, the lysosomes of macrophages from animals treated with cortisone revealed little, if any, interaction. This diminished lysosomal response in forming phagocytic vacuoles may be important in the subsequent development of hyphal bronchopneumonia which frequently occurs in cortisone-treated mice exposed to spores of A. flavus. |
| doi_str_mv | 10.1126/science.160.3823.79 |
| format | Article |
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Fifteen to 20 minutes later, animals were killed, and alveolar macrophages were obtained by tracheobronchial lavage. Electron-microscopic examination of these cells revealed that, whereas the lysosomes of control macrophages showed extensive attraction and fusion with the phagocytic membranes surrounding spores, the lysosomes of macrophages from animals treated with cortisone revealed little, if any, interaction. This diminished lysosomal response in forming phagocytic vacuoles may be important in the subsequent development of hyphal bronchopneumonia which frequently occurs in cortisone-treated mice exposed to spores of A. flavus.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.160.3823.79</identifier><identifier>PMID: 5642312</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Air Microbiology ; Alveolar macrophages ; Animals ; Aragonite ; Aspergillosis - etiology ; Aspergillosis - pathology ; Blood plasma ; Bronchopneumonia - etiology ; Childbirth ; Cortisone - pharmacology ; Female ; Fungal spores ; Groundwater ; Lung Diseases, Fungal - etiology ; Lung Diseases, Fungal - pathology ; Lysosomes ; Lysosomes - cytology ; Lysosomes - drug effects ; Macrophages ; Macrophages - cytology ; Membranes - drug effects ; Mice ; Microscopy, Electron ; P branes ; Phagocytosis ; Pulmonary Alveoli - cytology ; Spores</subject><ispartof>Science (American Association for the Advancement of Science), 1968-04, Vol.160 (3823), p.79-81</ispartof><rights>Copyright 1968 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-7b80d08f1a6eb3f8fe4acb954004880324dd395748f26a41211f78ec183936f93</citedby><cites>FETCH-LOGICAL-c350t-7b80d08f1a6eb3f8fe4acb954004880324dd395748f26a41211f78ec183936f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1724666$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1724666$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5642312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merkow, Leonard</creatorcontrib><creatorcontrib>Pardo, Matias</creatorcontrib><creatorcontrib>Epstein, Sheldon M.</creatorcontrib><creatorcontrib>Verney, Ethel</creatorcontrib><creatorcontrib>Sidransky, Herschel</creatorcontrib><title>Lysosomal Stability during Phagocytosis of Aspergillus flavus Spores by Alveolar Macrophages of Cortisone-Treated Mice</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Control mice and those treated with cortisone were exposed to aerosols of viable spores of Aspergillus flavus. Fifteen to 20 minutes later, animals were killed, and alveolar macrophages were obtained by tracheobronchial lavage. Electron-microscopic examination of these cells revealed that, whereas the lysosomes of control macrophages showed extensive attraction and fusion with the phagocytic membranes surrounding spores, the lysosomes of macrophages from animals treated with cortisone revealed little, if any, interaction. This diminished lysosomal response in forming phagocytic vacuoles may be important in the subsequent development of hyphal bronchopneumonia which frequently occurs in cortisone-treated mice exposed to spores of A. flavus.</description><subject>Air Microbiology</subject><subject>Alveolar macrophages</subject><subject>Animals</subject><subject>Aragonite</subject><subject>Aspergillosis - etiology</subject><subject>Aspergillosis - pathology</subject><subject>Blood plasma</subject><subject>Bronchopneumonia - etiology</subject><subject>Childbirth</subject><subject>Cortisone - pharmacology</subject><subject>Female</subject><subject>Fungal spores</subject><subject>Groundwater</subject><subject>Lung Diseases, Fungal - etiology</subject><subject>Lung Diseases, Fungal - pathology</subject><subject>Lysosomes</subject><subject>Lysosomes - cytology</subject><subject>Lysosomes - drug effects</subject><subject>Macrophages</subject><subject>Macrophages - cytology</subject><subject>Membranes - drug effects</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>P branes</subject><subject>Phagocytosis</subject><subject>Pulmonary Alveoli - cytology</subject><subject>Spores</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEuP0zAUhS0EGjoDvwCQvGKX4lccZ1lVPEbqCKQZ1pbjXBeP3Dr4JpXy70lpBau7OOd8uvoIecfZmnOhP6GPcPSw5pqtpRFy3bQvyIqztq5aweRLsmJM6sqwpn5NbhGfGVuyVt6Qm1orIblYkdNuxoz54BJ9HF0XUxxn2k8lHvf0xy-3z34eM0akOdANDlD2MaUJaUjutJzHIRdA2s10k06Qkyv0wfmSh2UKf0fbXMaI-QjVUwE3Qk8fooc35FVwCeHt9d6Rn18-P22_VbvvX--3m13lZc3GqukM65kJ3GnoZDABlPNdWyvGlDFMCtX3sq0bZYLQTnHBeWgMeG5kK3Vo5R35eOEOJf-eAEd7iOghJXeEPKE1avHWSLEU5aW4PI9YINihxIMrs-XMnm3bq2272LZn27Y54z9c8VN3gP7f5qp3yd9f8mccc_mPbITSWss_AruH9g</recordid><startdate>19680405</startdate><enddate>19680405</enddate><creator>Merkow, Leonard</creator><creator>Pardo, Matias</creator><creator>Epstein, Sheldon M.</creator><creator>Verney, Ethel</creator><creator>Sidransky, Herschel</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19680405</creationdate><title>Lysosomal Stability during Phagocytosis of Aspergillus flavus Spores by Alveolar Macrophages of Cortisone-Treated Mice</title><author>Merkow, Leonard ; Pardo, Matias ; Epstein, Sheldon M. ; Verney, Ethel ; Sidransky, Herschel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-7b80d08f1a6eb3f8fe4acb954004880324dd395748f26a41211f78ec183936f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Air Microbiology</topic><topic>Alveolar macrophages</topic><topic>Animals</topic><topic>Aragonite</topic><topic>Aspergillosis - etiology</topic><topic>Aspergillosis - pathology</topic><topic>Blood plasma</topic><topic>Bronchopneumonia - etiology</topic><topic>Childbirth</topic><topic>Cortisone - pharmacology</topic><topic>Female</topic><topic>Fungal spores</topic><topic>Groundwater</topic><topic>Lung Diseases, Fungal - etiology</topic><topic>Lung Diseases, Fungal - pathology</topic><topic>Lysosomes</topic><topic>Lysosomes - cytology</topic><topic>Lysosomes - drug effects</topic><topic>Macrophages</topic><topic>Macrophages - cytology</topic><topic>Membranes - drug effects</topic><topic>Mice</topic><topic>Microscopy, Electron</topic><topic>P branes</topic><topic>Phagocytosis</topic><topic>Pulmonary Alveoli - cytology</topic><topic>Spores</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Merkow, Leonard</creatorcontrib><creatorcontrib>Pardo, Matias</creatorcontrib><creatorcontrib>Epstein, Sheldon M.</creatorcontrib><creatorcontrib>Verney, Ethel</creatorcontrib><creatorcontrib>Sidransky, Herschel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Merkow, Leonard</au><au>Pardo, Matias</au><au>Epstein, Sheldon M.</au><au>Verney, Ethel</au><au>Sidransky, Herschel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lysosomal Stability during Phagocytosis of Aspergillus flavus Spores by Alveolar Macrophages of Cortisone-Treated Mice</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1968-04-05</date><risdate>1968</risdate><volume>160</volume><issue>3823</issue><spage>79</spage><epage>81</epage><pages>79-81</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Control mice and those treated with cortisone were exposed to aerosols of viable spores of Aspergillus flavus. Fifteen to 20 minutes later, animals were killed, and alveolar macrophages were obtained by tracheobronchial lavage. Electron-microscopic examination of these cells revealed that, whereas the lysosomes of control macrophages showed extensive attraction and fusion with the phagocytic membranes surrounding spores, the lysosomes of macrophages from animals treated with cortisone revealed little, if any, interaction. This diminished lysosomal response in forming phagocytic vacuoles may be important in the subsequent development of hyphal bronchopneumonia which frequently occurs in cortisone-treated mice exposed to spores of A. flavus.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>5642312</pmid><doi>10.1126/science.160.3823.79</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1968-04, Vol.160 (3823), p.79-81 |
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| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Air Microbiology Alveolar macrophages Animals Aragonite Aspergillosis - etiology Aspergillosis - pathology Blood plasma Bronchopneumonia - etiology Childbirth Cortisone - pharmacology Female Fungal spores Groundwater Lung Diseases, Fungal - etiology Lung Diseases, Fungal - pathology Lysosomes Lysosomes - cytology Lysosomes - drug effects Macrophages Macrophages - cytology Membranes - drug effects Mice Microscopy, Electron P branes Phagocytosis Pulmonary Alveoli - cytology Spores |
| title | Lysosomal Stability during Phagocytosis of Aspergillus flavus Spores by Alveolar Macrophages of Cortisone-Treated Mice |
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