Myocardial and local anesthetic actions of β-adrenergic receptor blocking drugs: Relationship to physicochemical properties

In 19 compoundsstudied, there was no simple relationship between β-blocking potency, lipoid solubility, pK a, or propensity for depressing myocardial contraction. No correlation existed between lipoid solubility and negative inotropism on isolated rabbit atria. Pronethalol and propranolol (CHCl 3/H...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1968-02, Vol.2 (4), p.250-257
1. Verfasser:	Levy, Joseph V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Alcohols - pharmacology Anesthesia, Local Anilides Animals Chemical Phenomena Chemistry, Physical Depression, Chemical Electric Stimulation Ethanolamines - pharmacology Heart - drug effects Heart Atria - drug effects Lipids local anesthetic effects of β-adrenergic blockers Muscle Contraction - drug effects Myocardial Nitrobenzenes - pharmacology Physicochemical properties of β-adrenergic blocking drugs Propranolol - pharmacology Rabbits Solubility Structure-activity relations of β-adrenergic blocking drugs Sympatholytics - pharmacology β-adrenergic blocking drugs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!