Collagenase activity in the gastro-intestinal tract
An experimental study in rabbits demonstrates that a significant postoperative decrease in bursting wall pressure is associated with a similar reduction in the colonic collagen from around the anastomosis. Mature collagen is broken down by the action of specific enzyme collagenase. This has been est...
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| Veröffentlicht in: | British journal of surgery 1970-12, Vol.57 (12), p.896-900 |
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| container_title | British journal of surgery |
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| creator | Hawley, P. R. Faulk, W. Page Hunt, T. K. Dunphy, J. E. |
| description | An experimental study in rabbits demonstrates that a significant postoperative decrease in bursting wall pressure is associated with a similar reduction in the colonic collagen from around the anastomosis.
Mature collagen is broken down by the action of specific enzyme collagenase. This has been estimated by a tissue‐culture method and is produced by viable explants of mucosa. There is a significant increase in the amount of this enzyme produced post‐operatively and it is suggested that this is responsible for the decrease in collagen and weakness of the colon.
An increased amount of enzyme is produced by explants from the colon than from those of other parts of the gastro‐intestinal tract. This is regarded as an important reason for the high incidence of colonic and rectal anastomotic breakdown compared with breakdown of anastomoses in other parts of the gastro‐intestinal tract.
Following colonic anastomosis there is increased collagenase production not only locally but throughout the gastro‐intestinal tract, suggesting that wound healing is not only under local control. |
| doi_str_mv | 10.1002/bjs.1800571206 |
| format | Article |
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Mature collagen is broken down by the action of specific enzyme collagenase. This has been estimated by a tissue‐culture method and is produced by viable explants of mucosa. There is a significant increase in the amount of this enzyme produced post‐operatively and it is suggested that this is responsible for the decrease in collagen and weakness of the colon.
An increased amount of enzyme is produced by explants from the colon than from those of other parts of the gastro‐intestinal tract. This is regarded as an important reason for the high incidence of colonic and rectal anastomotic breakdown compared with breakdown of anastomoses in other parts of the gastro‐intestinal tract.
Following colonic anastomosis there is increased collagenase production not only locally but throughout the gastro‐intestinal tract, suggesting that wound healing is not only under local control.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800571206</identifier><identifier>PMID: 4321082</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biomechanical Phenomena ; Collagen - analysis ; Colon - analysis ; Colon - surgery ; Culture Techniques ; Digestive System - enzymology ; Intestinal Mucosa - enzymology ; Male ; Microbial Collagenase - biosynthesis ; Microbial Collagenase - metabolism ; Rabbits ; Rectum - surgery ; Wound Healing</subject><ispartof>British journal of surgery, 1970-12, Vol.57 (12), p.896-900</ispartof><rights>Copyright © 1970 British Journal of Surgery Society Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3206-6e8559b544a80c35e15579410c7a9347991518214de281f8e2db390d701ccd853</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800571206$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800571206$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4321082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawley, P. R.</creatorcontrib><creatorcontrib>Faulk, W. Page</creatorcontrib><creatorcontrib>Hunt, T. K.</creatorcontrib><creatorcontrib>Dunphy, J. E.</creatorcontrib><title>Collagenase activity in the gastro-intestinal tract</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>An experimental study in rabbits demonstrates that a significant postoperative decrease in bursting wall pressure is associated with a similar reduction in the colonic collagen from around the anastomosis.
Mature collagen is broken down by the action of specific enzyme collagenase. This has been estimated by a tissue‐culture method and is produced by viable explants of mucosa. There is a significant increase in the amount of this enzyme produced post‐operatively and it is suggested that this is responsible for the decrease in collagen and weakness of the colon.
An increased amount of enzyme is produced by explants from the colon than from those of other parts of the gastro‐intestinal tract. This is regarded as an important reason for the high incidence of colonic and rectal anastomotic breakdown compared with breakdown of anastomoses in other parts of the gastro‐intestinal tract.
Following colonic anastomosis there is increased collagenase production not only locally but throughout the gastro‐intestinal tract, suggesting that wound healing is not only under local control.</description><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Collagen - analysis</subject><subject>Colon - analysis</subject><subject>Colon - surgery</subject><subject>Culture Techniques</subject><subject>Digestive System - enzymology</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Male</subject><subject>Microbial Collagenase - biosynthesis</subject><subject>Microbial Collagenase - metabolism</subject><subject>Rabbits</subject><subject>Rectum - surgery</subject><subject>Wound Healing</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1PwkAQxTdGg4hevZn05K04s9vtbo-Kihr8iKgcN9t2wcXSYreo_PcugcBpMnnvN3nzCDlF6CIAvUinrosSgAukEO-RNrKYhxRjuU_aACBCZJQdkiPnpgDIgNMWaUWMIkjaJqxXFYWemFI7E-issT-2WQa2DJpPE0y0a-oqtGVjXGNLXQRN7T3H5GCsC2dONrND3m9v3np34eC5f9-7HIQZ81HC2EjOk5RHkZaQMW6Qc5FECJnQCYtEkiBHSTHKDZU4lobmKUsgF4BZlkvOOuR8fXdeV98LH0HNrMuMz1uaauGU9Dc8vzKebYyLdGZyNa_tTNdLtfnS68la_7WFWW5lBLWqUPkK1a5CdfUw3G2eDdesdY3527K6_lKxYIKr0VNfjYZ4_fr4QdUL-wd9PHGz</recordid><startdate>197012</startdate><enddate>197012</enddate><creator>Hawley, P. R.</creator><creator>Faulk, W. Page</creator><creator>Hunt, T. K.</creator><creator>Dunphy, J. E.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197012</creationdate><title>Collagenase activity in the gastro-intestinal tract</title><author>Hawley, P. R. ; Faulk, W. Page ; Hunt, T. K. ; Dunphy, J. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3206-6e8559b544a80c35e15579410c7a9347991518214de281f8e2db390d701ccd853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>Collagen - analysis</topic><topic>Colon - analysis</topic><topic>Colon - surgery</topic><topic>Culture Techniques</topic><topic>Digestive System - enzymology</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Male</topic><topic>Microbial Collagenase - biosynthesis</topic><topic>Microbial Collagenase - metabolism</topic><topic>Rabbits</topic><topic>Rectum - surgery</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawley, P. R.</creatorcontrib><creatorcontrib>Faulk, W. Page</creatorcontrib><creatorcontrib>Hunt, T. K.</creatorcontrib><creatorcontrib>Dunphy, J. E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawley, P. R.</au><au>Faulk, W. Page</au><au>Hunt, T. K.</au><au>Dunphy, J. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagenase activity in the gastro-intestinal tract</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1970-12</date><risdate>1970</risdate><volume>57</volume><issue>12</issue><spage>896</spage><epage>900</epage><pages>896-900</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><abstract>An experimental study in rabbits demonstrates that a significant postoperative decrease in bursting wall pressure is associated with a similar reduction in the colonic collagen from around the anastomosis.
Mature collagen is broken down by the action of specific enzyme collagenase. This has been estimated by a tissue‐culture method and is produced by viable explants of mucosa. There is a significant increase in the amount of this enzyme produced post‐operatively and it is suggested that this is responsible for the decrease in collagen and weakness of the colon.
An increased amount of enzyme is produced by explants from the colon than from those of other parts of the gastro‐intestinal tract. This is regarded as an important reason for the high incidence of colonic and rectal anastomotic breakdown compared with breakdown of anastomoses in other parts of the gastro‐intestinal tract.
Following colonic anastomosis there is increased collagenase production not only locally but throughout the gastro‐intestinal tract, suggesting that wound healing is not only under local control.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>4321082</pmid><doi>10.1002/bjs.1800571206</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of surgery, 1970-12, Vol.57 (12), p.896-900 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biomechanical Phenomena Collagen - analysis Colon - analysis Colon - surgery Culture Techniques Digestive System - enzymology Intestinal Mucosa - enzymology Male Microbial Collagenase - biosynthesis Microbial Collagenase - metabolism Rabbits Rectum - surgery Wound Healing |
| title | Collagenase activity in the gastro-intestinal tract |
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