Indospicine, a New Hepatotoxic Amino-acid from Indigofera spicata
Indigofera spicata Forsk (previously I. endecaphylla Jacq.) would be a useful tropical pasture legume without its toxic properties (for review, see ref. 1). It has been shown to be hepatotoxic to sheep, cows and rabbits, and has caused abortion in pregnant animals 2 . Hutton et al. 3,4 showed that t...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 1968-01, Vol.217 (5126), p.354-355 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 355 |
|---|---|
| container_issue | 5126 |
| container_start_page | 354 |
| container_title | Nature (London) |
| container_volume | 217 |
| creator | HEGARTY, M. P POUND, A. W |
| description | Indigofera spicata
Forsk (previously
I. endecaphylla
Jacq.) would be a useful tropical pasture legume without its toxic properties (for review, see ref. 1). It has been shown to be hepatotoxic to sheep, cows and rabbits, and has caused abortion in pregnant animals
2
. Hutton
et al.
3,4
showed that the leaf and seed were hepatotoxic to rabbits and mice and that β-nitropropionic acid, which occurs only in the leaf, did not account for these liver lesions. Britten
et al.
5
found that β-nitropropionic acid or a compound closely associated with it in the leaf was toxic to chicks, which were not affected by the hepatotoxin(s) present in the seed. |
| doi_str_mv | 10.1038/217354a0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_84797587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>84797587</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-4ce28771218febdd533591a11727b507f153bf52435cf25a3e2338a5c54d2a733</originalsourceid><addsrcrecordid>eNptkE1Lw0AURQdRaq2Cf0DJShSMzmdmuixFbaHoRtdhMnlTpjSZOJOg_ntTUrty9Rb33APvInRJ8APBTD1SIpngGh-hMeEyS3mm5DEaY0xVihXLTtFZjBuMsSCSj9BIZGxKBB6j2bIufWyccTXcJzp5ha9kAY1ufeu_nUlmlat9qo0rExt8lfS4W3sLQSe7lm71OTqxehvhYn8n6OP56X2-SFdvL8v5bJUajkmbcgNUSUkoURaKshSMiSnRhEgqC4GlJYIVVlDOhLFUaAaUMaWFEbykWjI2QTeDtwn-s4PY5pWLBrZbXYPvYq64nEqhZA_eDqAJPsYANm-Cq3T4yQnOd2vlf2v16NXe2RUVlAdwP0-f3w157JN6DSHf-C7U_Zv_ua4HttZtF-DgOgC_IxF5gQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84797587</pqid></control><display><type>article</type><title>Indospicine, a New Hepatotoxic Amino-acid from Indigofera spicata</title><source>MEDLINE</source><source>Nature</source><source>SpringerNature Journals</source><creator>HEGARTY, M. P ; POUND, A. W</creator><creatorcontrib>HEGARTY, M. P ; POUND, A. W</creatorcontrib><description>Indigofera spicata
Forsk (previously
I. endecaphylla
Jacq.) would be a useful tropical pasture legume without its toxic properties (for review, see ref. 1). It has been shown to be hepatotoxic to sheep, cows and rabbits, and has caused abortion in pregnant animals
2
. Hutton
et al.
3,4
showed that the leaf and seed were hepatotoxic to rabbits and mice and that β-nitropropionic acid, which occurs only in the leaf, did not account for these liver lesions. Britten
et al.
5
found that β-nitropropionic acid or a compound closely associated with it in the leaf was toxic to chicks, which were not affected by the hepatotoxin(s) present in the seed.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/217354a0</identifier><identifier>PMID: 5639150</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Caproates - pharmacology ; Humanities and Social Sciences ; letter ; Liver - drug effects ; Mice ; multidisciplinary ; Plants - analysis ; Science ; Science (multidisciplinary) ; Seeds - analysis</subject><ispartof>Nature (London), 1968-01, Vol.217 (5126), p.354-355</ispartof><rights>Springer Nature Limited 1968</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-4ce28771218febdd533591a11727b507f153bf52435cf25a3e2338a5c54d2a733</citedby><cites>FETCH-LOGICAL-c401t-4ce28771218febdd533591a11727b507f153bf52435cf25a3e2338a5c54d2a733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/217354a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/217354a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5639150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HEGARTY, M. P</creatorcontrib><creatorcontrib>POUND, A. W</creatorcontrib><title>Indospicine, a New Hepatotoxic Amino-acid from Indigofera spicata</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Indigofera spicata
Forsk (previously
I. endecaphylla
Jacq.) would be a useful tropical pasture legume without its toxic properties (for review, see ref. 1). It has been shown to be hepatotoxic to sheep, cows and rabbits, and has caused abortion in pregnant animals
2
. Hutton
et al.
3,4
showed that the leaf and seed were hepatotoxic to rabbits and mice and that β-nitropropionic acid, which occurs only in the leaf, did not account for these liver lesions. Britten
et al.
5
found that β-nitropropionic acid or a compound closely associated with it in the leaf was toxic to chicks, which were not affected by the hepatotoxin(s) present in the seed.</description><subject>Animals</subject><subject>Caproates - pharmacology</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Liver - drug effects</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Plants - analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Seeds - analysis</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1Lw0AURQdRaq2Cf0DJShSMzmdmuixFbaHoRtdhMnlTpjSZOJOg_ntTUrty9Rb33APvInRJ8APBTD1SIpngGh-hMeEyS3mm5DEaY0xVihXLTtFZjBuMsSCSj9BIZGxKBB6j2bIufWyccTXcJzp5ha9kAY1ufeu_nUlmlat9qo0rExt8lfS4W3sLQSe7lm71OTqxehvhYn8n6OP56X2-SFdvL8v5bJUajkmbcgNUSUkoURaKshSMiSnRhEgqC4GlJYIVVlDOhLFUaAaUMaWFEbykWjI2QTeDtwn-s4PY5pWLBrZbXYPvYq64nEqhZA_eDqAJPsYANm-Cq3T4yQnOd2vlf2v16NXe2RUVlAdwP0-f3w157JN6DSHf-C7U_Zv_ua4HttZtF-DgOgC_IxF5gQ</recordid><startdate>19680127</startdate><enddate>19680127</enddate><creator>HEGARTY, M. P</creator><creator>POUND, A. W</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19680127</creationdate><title>Indospicine, a New Hepatotoxic Amino-acid from Indigofera spicata</title><author>HEGARTY, M. P ; POUND, A. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-4ce28771218febdd533591a11727b507f153bf52435cf25a3e2338a5c54d2a733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Animals</topic><topic>Caproates - pharmacology</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Liver - drug effects</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Plants - analysis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Seeds - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HEGARTY, M. P</creatorcontrib><creatorcontrib>POUND, A. W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HEGARTY, M. P</au><au>POUND, A. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indospicine, a New Hepatotoxic Amino-acid from Indigofera spicata</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1968-01-27</date><risdate>1968</risdate><volume>217</volume><issue>5126</issue><spage>354</spage><epage>355</epage><pages>354-355</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Indigofera spicata
Forsk (previously
I. endecaphylla
Jacq.) would be a useful tropical pasture legume without its toxic properties (for review, see ref. 1). It has been shown to be hepatotoxic to sheep, cows and rabbits, and has caused abortion in pregnant animals
2
. Hutton
et al.
3,4
showed that the leaf and seed were hepatotoxic to rabbits and mice and that β-nitropropionic acid, which occurs only in the leaf, did not account for these liver lesions. Britten
et al.
5
found that β-nitropropionic acid or a compound closely associated with it in the leaf was toxic to chicks, which were not affected by the hepatotoxin(s) present in the seed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>5639150</pmid><doi>10.1038/217354a0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1968-01, Vol.217 (5126), p.354-355 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84797587 |
| source | MEDLINE; Nature; SpringerNature Journals |
| subjects | Animals Caproates - pharmacology Humanities and Social Sciences letter Liver - drug effects Mice multidisciplinary Plants - analysis Science Science (multidisciplinary) Seeds - analysis |
| title | Indospicine, a New Hepatotoxic Amino-acid from Indigofera spicata |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T16%3A01%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Indospicine,%20a%20New%20Hepatotoxic%20Amino-acid%20from%20Indigofera%20spicata&rft.jtitle=Nature%20(London)&rft.au=HEGARTY,%20M.%20P&rft.date=1968-01-27&rft.volume=217&rft.issue=5126&rft.spage=354&rft.epage=355&rft.pages=354-355&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/217354a0&rft_dat=%3Cproquest_cross%3E84797587%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84797587&rft_id=info:pmid/5639150&rfr_iscdi=true |