Pulmonary hypertension associated with cirrhosis of the liver and with portacaval shunts
Pulmonary hemodynamics were studied in 11 patients with hepatic cirrhosis who had undergone surgical portal decompression several years earlier. Four of the patients had both clinical and physiological evidence of pulmonary hypertension; two others had mild, subclinical pulmonary hypertension. Autop...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1968-01, Vol.37 (1), p.88-96 |
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| container_title | Circulation (New York, N.Y.) |
| container_volume | 37 |
| creator | Senior, R M Britton, R C Turino, G M Wood, J A Langer, G A Fishman, A P |
| description | Pulmonary hemodynamics were studied in 11 patients with hepatic cirrhosis who had undergone surgical portal decompression several years earlier. Four of the patients had both clinical and physiological evidence of pulmonary hypertension; two others had mild, subclinical pulmonary hypertension. Autopsy examination of two patients who had clinical evidence of pulmonary hypertension revealed thickening of the small pulmonary arteries and multiple small pulmonary emboli. Before the portosystemic venous anastomosis was created, all of the patients had had normal cardiorespiratory performance. These studies suggest that emboli from the portal vein may have been involved in the genesis of the pulmonary hypertension in these patients. The role of surgical portal decompression is unclear. Retrospective studies of 70 clinical records and of 17 autopsy protocols in a similar group of patients did not clarify the role of the surgical decompression in the genesis of the pulmonary hypertension. |
| doi_str_mv | 10.1161/01.CIR.37.1.88 |
| format | Article |
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Four of the patients had both clinical and physiological evidence of pulmonary hypertension; two others had mild, subclinical pulmonary hypertension. Autopsy examination of two patients who had clinical evidence of pulmonary hypertension revealed thickening of the small pulmonary arteries and multiple small pulmonary emboli. Before the portosystemic venous anastomosis was created, all of the patients had had normal cardiorespiratory performance. These studies suggest that emboli from the portal vein may have been involved in the genesis of the pulmonary hypertension in these patients. The role of surgical portal decompression is unclear. Retrospective studies of 70 clinical records and of 17 autopsy protocols in a similar group of patients did not clarify the role of the surgical decompression in the genesis of the pulmonary hypertension.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.37.1.88</identifier><identifier>PMID: 5634734</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Alkaline Phosphatase - blood ; Bilirubin - blood ; Blood Pressure ; Carbon Dioxide - blood ; Female ; Heart Ventricles ; Hemodynamics ; Hemoglobinometry ; Humans ; Hydrogen-Ion Concentration ; Hypertension, Pulmonary - blood ; Hypertension, Pulmonary - etiology ; Liver Cirrhosis - blood ; Liver Cirrhosis - complications ; Lung - pathology ; Male ; Middle Aged ; Oxygen - blood ; Portacaval Shunt, Surgical ; Pulmonary Embolism - complications ; Serum Albumin - analysis</subject><ispartof>Circulation (New York, N.Y.), 1968-01, Vol.37 (1), p.88-96</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-eb545b48331fa9caff7f1e5e2541ad814d6ccb2f4442601bdab847ff861ddc113</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3674,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5634734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Senior, R M</creatorcontrib><creatorcontrib>Britton, R C</creatorcontrib><creatorcontrib>Turino, G M</creatorcontrib><creatorcontrib>Wood, J A</creatorcontrib><creatorcontrib>Langer, G A</creatorcontrib><creatorcontrib>Fishman, A P</creatorcontrib><title>Pulmonary hypertension associated with cirrhosis of the liver and with portacaval shunts</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Pulmonary hemodynamics were studied in 11 patients with hepatic cirrhosis who had undergone surgical portal decompression several years earlier. Four of the patients had both clinical and physiological evidence of pulmonary hypertension; two others had mild, subclinical pulmonary hypertension. Autopsy examination of two patients who had clinical evidence of pulmonary hypertension revealed thickening of the small pulmonary arteries and multiple small pulmonary emboli. Before the portosystemic venous anastomosis was created, all of the patients had had normal cardiorespiratory performance. These studies suggest that emboli from the portal vein may have been involved in the genesis of the pulmonary hypertension in these patients. The role of surgical portal decompression is unclear. Retrospective studies of 70 clinical records and of 17 autopsy protocols in a similar group of patients did not clarify the role of the surgical decompression in the genesis of the pulmonary hypertension.</description><subject>Adult</subject><subject>Alkaline Phosphatase - blood</subject><subject>Bilirubin - blood</subject><subject>Blood Pressure</subject><subject>Carbon Dioxide - blood</subject><subject>Female</subject><subject>Heart Ventricles</subject><subject>Hemodynamics</subject><subject>Hemoglobinometry</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypertension, Pulmonary - blood</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - complications</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen - blood</subject><subject>Portacaval Shunt, Surgical</subject><subject>Pulmonary Embolism - complications</subject><subject>Serum Albumin - analysis</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo67p69Sbk5K210yRtepTFj4UFRRS8hTRNaKRtapKu7L-3sounYZjnfWEehK4hSwEKuMsgXW_eUlKmkHJ-gpbAcppQRqpTtMyyrEpKkufn6CKEr3ktSMkWaMEKQktCl-jzdep6N0i_x-1-1D7qIVg3YBmCU1ZG3eAfG1usrPetCzZgZ3BsNe7sTnssh-N9dD5KJXeyw6Gdhhgu0ZmRXdBXx7lCH48P7-vnZPvytFnfbxNFiiomumaU1ZQTAkZWShpTGtBM54yCbDjQplCqzg2lNC8yqBtZc1oawwtoGgVAVuj20Dt69z3pEEVvg9JdJwftpiBmmlW0oDOYHkDlXQheGzF628-PC8jEn0qRgZhVClIKEJzPgZtj81T3uvnHj-7ILzfqcS0</recordid><startdate>196801</startdate><enddate>196801</enddate><creator>Senior, R M</creator><creator>Britton, R C</creator><creator>Turino, G M</creator><creator>Wood, J A</creator><creator>Langer, G A</creator><creator>Fishman, A P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196801</creationdate><title>Pulmonary hypertension associated with cirrhosis of the liver and with portacaval shunts</title><author>Senior, R M ; Britton, R C ; Turino, G M ; Wood, J A ; Langer, G A ; Fishman, A P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-eb545b48331fa9caff7f1e5e2541ad814d6ccb2f4442601bdab847ff861ddc113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - blood</topic><topic>Bilirubin - blood</topic><topic>Blood Pressure</topic><topic>Carbon Dioxide - blood</topic><topic>Female</topic><topic>Heart Ventricles</topic><topic>Hemodynamics</topic><topic>Hemoglobinometry</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypertension, Pulmonary - blood</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - complications</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen - blood</topic><topic>Portacaval Shunt, Surgical</topic><topic>Pulmonary Embolism - complications</topic><topic>Serum Albumin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Senior, R M</creatorcontrib><creatorcontrib>Britton, R C</creatorcontrib><creatorcontrib>Turino, G M</creatorcontrib><creatorcontrib>Wood, J A</creatorcontrib><creatorcontrib>Langer, G A</creatorcontrib><creatorcontrib>Fishman, A P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Senior, R M</au><au>Britton, R C</au><au>Turino, G M</au><au>Wood, J A</au><au>Langer, G A</au><au>Fishman, A P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary hypertension associated with cirrhosis of the liver and with portacaval shunts</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1968-01</date><risdate>1968</risdate><volume>37</volume><issue>1</issue><spage>88</spage><epage>96</epage><pages>88-96</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Pulmonary hemodynamics were studied in 11 patients with hepatic cirrhosis who had undergone surgical portal decompression several years earlier. Four of the patients had both clinical and physiological evidence of pulmonary hypertension; two others had mild, subclinical pulmonary hypertension. Autopsy examination of two patients who had clinical evidence of pulmonary hypertension revealed thickening of the small pulmonary arteries and multiple small pulmonary emboli. Before the portosystemic venous anastomosis was created, all of the patients had had normal cardiorespiratory performance. These studies suggest that emboli from the portal vein may have been involved in the genesis of the pulmonary hypertension in these patients. The role of surgical portal decompression is unclear. Retrospective studies of 70 clinical records and of 17 autopsy protocols in a similar group of patients did not clarify the role of the surgical decompression in the genesis of the pulmonary hypertension.</abstract><cop>United States</cop><pmid>5634734</pmid><doi>10.1161/01.CIR.37.1.88</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1968-01, Vol.37 (1), p.88-96 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adult Alkaline Phosphatase - blood Bilirubin - blood Blood Pressure Carbon Dioxide - blood Female Heart Ventricles Hemodynamics Hemoglobinometry Humans Hydrogen-Ion Concentration Hypertension, Pulmonary - blood Hypertension, Pulmonary - etiology Liver Cirrhosis - blood Liver Cirrhosis - complications Lung - pathology Male Middle Aged Oxygen - blood Portacaval Shunt, Surgical Pulmonary Embolism - complications Serum Albumin - analysis |
| title | Pulmonary hypertension associated with cirrhosis of the liver and with portacaval shunts |
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