Hepatitis Virus: Effect of Heat on the Infectivity and Antigenicity of the MS-1 and MS-2 Strains
A serum pool containing the MS-1 strain of viral hepatitis, type A (IH) was boiled for 1 min at a temperature of 98 C. The heated serum was neither infectious nor immunogenic; it did not protect susceptible individuals who were infected by the unheated MS-1 serum pool S months later. A serum pool co...
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| Veröffentlicht in: | The Journal of infectious diseases 1970-11, Vol.122 (5), p.432-436 |
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| container_title | The Journal of infectious diseases |
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| creator | Krugman, Saul Giles, Joan P. Hammond, Jack |
| description | A serum pool containing the MS-1 strain of viral hepatitis, type A (IH) was boiled for 1 min at a temperature of 98 C. The heated serum was neither infectious nor immunogenic; it did not protect susceptible individuals who were infected by the unheated MS-1 serum pool S months later. A serum pool containing the MS-2 strain of viral hepatitis, type B (SH) was boiled for 1 min at 98 C. This treatment modified infectivity with out affecting antigenicity. The complement-fixation titer of hepatitis-associated antigen was not significantly affected by the heating. |
| doi_str_mv | 10.1093/infdis/122.5.432 |
| format | Article |
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The heated serum was neither infectious nor immunogenic; it did not protect susceptible individuals who were infected by the unheated MS-1 serum pool S months later. A serum pool containing the MS-2 strain of viral hepatitis, type B (SH) was boiled for 1 min at 98 C. This treatment modified infectivity with out affecting antigenicity. The complement-fixation titer of hepatitis-associated antigen was not significantly affected by the heating.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/122.5.432</identifier><identifier>PMID: 5476393</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Antigen-Antibody Reactions ; Antigens ; Child ; Child, Preschool ; Complement Fixation Tests ; Flasks ; Furunculosis ; Hepatitis ; Hepatitis A ; Hepatitis B virus - pathogenicity ; Hepatitis viruses ; Hepatitis Viruses - immunology ; Hepatitis Viruses - pathogenicity ; Hot Temperature ; Humans ; Infectious diseases ; Liquids ; Original Articles ; Viral hepatitis ; Viruses</subject><ispartof>The Journal of infectious diseases, 1970-11, Vol.122 (5), p.432-436</ispartof><rights>Copyright 1970 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-55c71d6192e992e5fdaab1ceb11893973e034fd1112f8cfe8f2abdd2efb5394c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30108355$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30108355$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27907,27908,58000,58233</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5476393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krugman, Saul</creatorcontrib><creatorcontrib>Giles, Joan P.</creatorcontrib><creatorcontrib>Hammond, Jack</creatorcontrib><title>Hepatitis Virus: Effect of Heat on the Infectivity and Antigenicity of the MS-1 and MS-2 Strains</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>A serum pool containing the MS-1 strain of viral hepatitis, type A (IH) was boiled for 1 min at a temperature of 98 C. 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The complement-fixation titer of hepatitis-associated antigen was not significantly affected by the heating.</description><subject>Antigen-Antibody Reactions</subject><subject>Antigens</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Complement Fixation Tests</subject><subject>Flasks</subject><subject>Furunculosis</subject><subject>Hepatitis</subject><subject>Hepatitis A</subject><subject>Hepatitis B virus - pathogenicity</subject><subject>Hepatitis viruses</subject><subject>Hepatitis Viruses - immunology</subject><subject>Hepatitis Viruses - pathogenicity</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liquids</subject><subject>Original Articles</subject><subject>Viral hepatitis</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1PGzEQhi1URAPl3ksln3rb4PHY-9Eb4qMBBaEqtEJcXK_Xbk2T3dR2EPx7HBKFgzXWPO-MRg8hn4GNgTV44nvX-XgCnI_lWCDfIyOQWBVlCfiBjBjjvIC6aT6SwxgfGWMCy-qAHEhRldjgiPye2KVOPvlIf_mwit_ohXPWJDo4OrE6156mv5Ze9euuf_Lpheq-o6d98n9s7826kbPrzM2sgDeYP5zOUtC-j5_IvtPzaI-39Yj8vLy4O5sU09vvV2en08KgFKmQ0lTQldBw2-QnXad1C8a2kM_HpkLLULgOALirjbO147rtOm5dK7ERBo_I183eZRj-r2xMauGjsfO57u2wiqoWlahrCTnINkEThhiDdWoZ_EKHFwVMraWqjVSVpSqpstQ88mW7e9UubLcb2Fp8548xDWGHkQGrUcrMiw33MdnnHdfhnyorrKSa3D-omfhxWd6dX6spvgLZuIwl</recordid><startdate>197011</startdate><enddate>197011</enddate><creator>Krugman, Saul</creator><creator>Giles, Joan P.</creator><creator>Hammond, Jack</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197011</creationdate><title>Hepatitis Virus: Effect of Heat on the Infectivity and Antigenicity of the MS-1 and MS-2 Strains</title><author>Krugman, Saul ; Giles, Joan P. ; Hammond, Jack</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-55c71d6192e992e5fdaab1ceb11893973e034fd1112f8cfe8f2abdd2efb5394c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Antigen-Antibody Reactions</topic><topic>Antigens</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Complement Fixation Tests</topic><topic>Flasks</topic><topic>Furunculosis</topic><topic>Hepatitis</topic><topic>Hepatitis A</topic><topic>Hepatitis B virus - pathogenicity</topic><topic>Hepatitis viruses</topic><topic>Hepatitis Viruses - immunology</topic><topic>Hepatitis Viruses - pathogenicity</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liquids</topic><topic>Original Articles</topic><topic>Viral hepatitis</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krugman, Saul</creatorcontrib><creatorcontrib>Giles, Joan P.</creatorcontrib><creatorcontrib>Hammond, Jack</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krugman, Saul</au><au>Giles, Joan P.</au><au>Hammond, Jack</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis Virus: Effect of Heat on the Infectivity and Antigenicity of the MS-1 and MS-2 Strains</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1970-11</date><risdate>1970</risdate><volume>122</volume><issue>5</issue><spage>432</spage><epage>436</epage><pages>432-436</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>A serum pool containing the MS-1 strain of viral hepatitis, type A (IH) was boiled for 1 min at a temperature of 98 C. The heated serum was neither infectious nor immunogenic; it did not protect susceptible individuals who were infected by the unheated MS-1 serum pool S months later. A serum pool containing the MS-2 strain of viral hepatitis, type B (SH) was boiled for 1 min at 98 C. This treatment modified infectivity with out affecting antigenicity. The complement-fixation titer of hepatitis-associated antigen was not significantly affected by the heating.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>5476393</pmid><doi>10.1093/infdis/122.5.432</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1970-11, Vol.122 (5), p.432-436 |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Antigen-Antibody Reactions Antigens Child Child, Preschool Complement Fixation Tests Flasks Furunculosis Hepatitis Hepatitis A Hepatitis B virus - pathogenicity Hepatitis viruses Hepatitis Viruses - immunology Hepatitis Viruses - pathogenicity Hot Temperature Humans Infectious diseases Liquids Original Articles Viral hepatitis Viruses |
| title | Hepatitis Virus: Effect of Heat on the Infectivity and Antigenicity of the MS-1 and MS-2 Strains |
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