miR-126 functions as a tumour suppressor in human gastric cancer

Abstract MicroRNAs have emerged as important gene regulators and are recognised as key players in carcinogenesis. In the present study, we show that miR-126 was significantly down-regulated in gastric cancer tissues compared with matched normal tissues and was associated with clinicopathological fea...

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Veröffentlicht in:	Cancer letters 2010-12, Vol.298 (1), p.50-63
Hauptverfasser:	Feng, Runhua, Chen, Xuehua, Yu, Yingyan, Su, Liping, Yu, Beiqin, Li, Jianfang, Cai, Qu, Yan, Min, Liu, Bingya, Zhu, Zhenggang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cancer therapies Carcinogenesis Cell cycle Cell Cycle - genetics Cell growth Cell Growth Processes - genetics Cell Line, Tumor Crk Down-Regulation Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor Hematology, Oncology and Palliative Medicine Hospitals Humans Infections Invasion Male Medicine Mice Mice, Nude MicroRNA MicroRNAs - biosynthesis MicroRNAs - genetics Proliferation Proteins Proto-Oncogene Proteins c-crk - biosynthesis Proto-Oncogene Proteins c-crk - genetics Stomach Neoplasms - genetics Stomach Neoplasms - pathology Technological change Transfection
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