Impact of excipients on coating efficiency in dry powder coating
The coating efficiency of dry powder coating can be increased by using excipients having a high spreadability resp. low contact angle on the polymer. Dry powder coating is a technique to coat substrates without the use of organic solvent or water. The polymer powder is directly applied to the cores...
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| Veröffentlicht in: | International journal of pharmaceutics 2011-02, Vol.405 (1), p.122-131 |
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| container_title | International journal of pharmaceutics |
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| creator | Smikalla, Martina Mescher, Axel Walzel, Peter Urbanetz, Nora Anne |
| description | The coating efficiency of dry powder coating can be increased by using excipients having a high spreadability resp. low contact angle on the polymer.
Dry powder coating is a technique to coat substrates without the use of organic solvent or water. The polymer powder is directly applied to the cores to be coated. Liquid additives are often used to lower the glass transition temperature of the polymer and to enhance the adhesion of the powder to the cores. This leads to an increase in coating efficiency of the process.
The impact of various liquid additives and their properties like spreading behavior, viscosity and plasticizing activity were investigated with respect to their influence on the coating efficiency of the process. Ethylcellulose and hydroxypropyl methylcellulose acetate succinate were used as coating polymers. Spreading behavior of the liquid additive on the polymer was the most influencing parameter and could be successfully predicted with contact angle measurements on polymer films. Calculations of works of adhesion and spreading coefficients also revealed to be promising predictive techniques for choosing suitable additives to improve process efficiency. Isopropyl myristate showed the best spreading behavior resulting in the highest coating efficiency.
Based on these results, a formulation for ethylcellulose containing isopropyl myristate was developed and film formation was examined using dissolution testing and imaging techniques to evaluate the optimum curing conditions. |
| doi_str_mv | 10.1016/j.ijpharm.2010.12.001 |
| format | Article |
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Dry powder coating is a technique to coat substrates without the use of organic solvent or water. The polymer powder is directly applied to the cores to be coated. Liquid additives are often used to lower the glass transition temperature of the polymer and to enhance the adhesion of the powder to the cores. This leads to an increase in coating efficiency of the process.
The impact of various liquid additives and their properties like spreading behavior, viscosity and plasticizing activity were investigated with respect to their influence on the coating efficiency of the process. Ethylcellulose and hydroxypropyl methylcellulose acetate succinate were used as coating polymers. Spreading behavior of the liquid additive on the polymer was the most influencing parameter and could be successfully predicted with contact angle measurements on polymer films. Calculations of works of adhesion and spreading coefficients also revealed to be promising predictive techniques for choosing suitable additives to improve process efficiency. Isopropyl myristate showed the best spreading behavior resulting in the highest coating efficiency.
Based on these results, a formulation for ethylcellulose containing isopropyl myristate was developed and film formation was examined using dissolution testing and imaging techniques to evaluate the optimum curing conditions.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2010.12.001</identifier><identifier>PMID: 21145382</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Cellulose - analogs & derivatives ; Cellulose - chemistry ; Cellulose - metabolism ; Coating efficiency ; Contact angle ; Drug Compounding ; Dry powder coating ; Ethylcellulose ; Excipients - chemistry ; General pharmacology ; Medical sciences ; Methylcellulose - analogs & derivatives ; Methylcellulose - chemistry ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymers - chemistry ; Powders - chemistry ; Powders - metabolism ; Pressure ; Rotary fluid bed ; Solubility ; Surface energy ; Surface Tension ; Sustained release ; Transition Temperature ; Viscosity</subject><ispartof>International journal of pharmaceutics, 2011-02, Vol.405 (1), p.122-131</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-9d37c4a7c48090014c77716d02937a7e45e8f785efd9f62190db52bec0958d0a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2010.12.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23834266$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21145382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smikalla, Martina</creatorcontrib><creatorcontrib>Mescher, Axel</creatorcontrib><creatorcontrib>Walzel, Peter</creatorcontrib><creatorcontrib>Urbanetz, Nora Anne</creatorcontrib><title>Impact of excipients on coating efficiency in dry powder coating</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The coating efficiency of dry powder coating can be increased by using excipients having a high spreadability resp. low contact angle on the polymer.
Dry powder coating is a technique to coat substrates without the use of organic solvent or water. The polymer powder is directly applied to the cores to be coated. Liquid additives are often used to lower the glass transition temperature of the polymer and to enhance the adhesion of the powder to the cores. This leads to an increase in coating efficiency of the process.
The impact of various liquid additives and their properties like spreading behavior, viscosity and plasticizing activity were investigated with respect to their influence on the coating efficiency of the process. Ethylcellulose and hydroxypropyl methylcellulose acetate succinate were used as coating polymers. Spreading behavior of the liquid additive on the polymer was the most influencing parameter and could be successfully predicted with contact angle measurements on polymer films. Calculations of works of adhesion and spreading coefficients also revealed to be promising predictive techniques for choosing suitable additives to improve process efficiency. Isopropyl myristate showed the best spreading behavior resulting in the highest coating efficiency.
Based on these results, a formulation for ethylcellulose containing isopropyl myristate was developed and film formation was examined using dissolution testing and imaging techniques to evaluate the optimum curing conditions.</description><subject>Biological and medical sciences</subject><subject>Cellulose - analogs & derivatives</subject><subject>Cellulose - chemistry</subject><subject>Cellulose - metabolism</subject><subject>Coating efficiency</subject><subject>Contact angle</subject><subject>Drug Compounding</subject><subject>Dry powder coating</subject><subject>Ethylcellulose</subject><subject>Excipients - chemistry</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Methylcellulose - chemistry</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymers - chemistry</subject><subject>Powders - chemistry</subject><subject>Powders - metabolism</subject><subject>Pressure</subject><subject>Rotary fluid bed</subject><subject>Solubility</subject><subject>Surface energy</subject><subject>Surface Tension</subject><subject>Sustained release</subject><subject>Transition Temperature</subject><subject>Viscosity</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQx4Motj4-grIX8bQ1r91kTyrFR6HgRc8hTSaa0n2YbNV-e1Pb6tHDMDD8ZubPD6EzgkcEk_JqPvLz7k2HekTxekZHGJM9NCRSsJxxUe6jIWZC5gURbICOYpxjjEtK2CEaUEJ4wSQdoptJ3WnTZ63L4Mv4zkPTx6xtMtPq3jevGTjnTZqaVeabzIZV1rWfFsIOOEEHTi8inG77MXq5v3seP-bTp4fJ-HaaG87LPq8sE4brVBJXKSk3QghSWkwrJrQAXoB0QhbgbOVSygrbWUFnYHBVSIs1O0aXm7tdaN-XEHtV-2hgsdANtMuoJBecFakSWWxIE9oYAzjVBV_rsFIEq7U7NVdbd2rtThGqUqK0d779sJzVYH-3drIScLEFdDR64YJujI9_HJOM07JM3PWGg-Tjw0NQ8ccgWB_A9Mq2_p8o32SujlA</recordid><startdate>20110228</startdate><enddate>20110228</enddate><creator>Smikalla, Martina</creator><creator>Mescher, Axel</creator><creator>Walzel, Peter</creator><creator>Urbanetz, Nora Anne</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110228</creationdate><title>Impact of excipients on coating efficiency in dry powder coating</title><author>Smikalla, Martina ; Mescher, Axel ; Walzel, Peter ; Urbanetz, Nora Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-9d37c4a7c48090014c77716d02937a7e45e8f785efd9f62190db52bec0958d0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Cellulose - analogs & derivatives</topic><topic>Cellulose - chemistry</topic><topic>Cellulose - metabolism</topic><topic>Coating efficiency</topic><topic>Contact angle</topic><topic>Drug Compounding</topic><topic>Dry powder coating</topic><topic>Ethylcellulose</topic><topic>Excipients - chemistry</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Methylcellulose - analogs & derivatives</topic><topic>Methylcellulose - chemistry</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymers - chemistry</topic><topic>Powders - chemistry</topic><topic>Powders - metabolism</topic><topic>Pressure</topic><topic>Rotary fluid bed</topic><topic>Solubility</topic><topic>Surface energy</topic><topic>Surface Tension</topic><topic>Sustained release</topic><topic>Transition Temperature</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smikalla, Martina</creatorcontrib><creatorcontrib>Mescher, Axel</creatorcontrib><creatorcontrib>Walzel, Peter</creatorcontrib><creatorcontrib>Urbanetz, Nora Anne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smikalla, Martina</au><au>Mescher, Axel</au><au>Walzel, Peter</au><au>Urbanetz, Nora Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of excipients on coating efficiency in dry powder coating</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2011-02-28</date><risdate>2011</risdate><volume>405</volume><issue>1</issue><spage>122</spage><epage>131</epage><pages>122-131</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>The coating efficiency of dry powder coating can be increased by using excipients having a high spreadability resp. low contact angle on the polymer.
Dry powder coating is a technique to coat substrates without the use of organic solvent or water. The polymer powder is directly applied to the cores to be coated. Liquid additives are often used to lower the glass transition temperature of the polymer and to enhance the adhesion of the powder to the cores. This leads to an increase in coating efficiency of the process.
The impact of various liquid additives and their properties like spreading behavior, viscosity and plasticizing activity were investigated with respect to their influence on the coating efficiency of the process. Ethylcellulose and hydroxypropyl methylcellulose acetate succinate were used as coating polymers. Spreading behavior of the liquid additive on the polymer was the most influencing parameter and could be successfully predicted with contact angle measurements on polymer films. Calculations of works of adhesion and spreading coefficients also revealed to be promising predictive techniques for choosing suitable additives to improve process efficiency. Isopropyl myristate showed the best spreading behavior resulting in the highest coating efficiency.
Based on these results, a formulation for ethylcellulose containing isopropyl myristate was developed and film formation was examined using dissolution testing and imaging techniques to evaluate the optimum curing conditions.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21145382</pmid><doi>10.1016/j.ijpharm.2010.12.001</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Cellulose - analogs & derivatives Cellulose - chemistry Cellulose - metabolism Coating efficiency Contact angle Drug Compounding Dry powder coating Ethylcellulose Excipients - chemistry General pharmacology Medical sciences Methylcellulose - analogs & derivatives Methylcellulose - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers - chemistry Powders - chemistry Powders - metabolism Pressure Rotary fluid bed Solubility Surface energy Surface Tension Sustained release Transition Temperature Viscosity |
| title | Impact of excipients on coating efficiency in dry powder coating |
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