4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents

A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as for their cytotoxicity toward VERO cell line. Five compounds ( 19, 20, 23, 41 and 45) exhibited the antimalari...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2011-02, Vol.46 (2), p.676-690
Hauptverfasser:	Kumar, Ashok, Srivastava, Kumkum, Raja Kumar, S., Siddiqi, M.I., Puri, Sunil K., Sexana, Jitendra K., Chauhan, Prem M.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-anilinoquinoline triazine Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarial Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Antiparasitic agents Biological and medical sciences Cell Proliferation - drug effects Cercopithecus aethiops Hemeproteins - antagonists & inhibitors Malaria - drug therapy Medical sciences Mice Models, Molecular Molecular Structure P. falciparum P. yoelii Parasitic Sensitivity Tests Pharmacology. Drug treatments Plasmodium falciparum - drug effects Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Stereoisomerism Structure-Activity Relationship Triazines - chemical synthesis Triazines - chemistry Triazines - pharmacology Vero Cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!