FOOT-AND-MOUTH DISEASE: THE AGAR GEL DIFFUSION PRECIPITIN TEST FOR ANTIBODY TO VIRUS-INFECTION-ASSOCIATED (VIA) ANTIGEN AS A TOOL FOR EPIZOOTIOLOGIC SURVEYS
McVicar, J. W. (Plum Island Animal Disease Lab., U. S. Dept. of Agriculture, P.O. Box 848, Greenport, N. Y. 11944) and P. Sutmoller. Foot-and-mouth disease: The agar gel diffusion precipitin test for antibody to virus-infection-associated (VIA) antigen as a tool for epizootiologic surveys. Amer. J....
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| Veröffentlicht in: | American journal of epidemiology 1970-10, Vol.92 (4), p.273-278 |
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| description | McVicar, J. W. (Plum Island Animal Disease Lab., U. S. Dept. of Agriculture, P.O. Box 848, Greenport, N. Y. 11944) and P. Sutmoller. Foot-and-mouth disease: The agar gel diffusion precipitin test for antibody to virus-infection-associated (VIA) antigen as a tool for epizootiologic surveys. Amer. J. Epid., 1970, 92; 273–278.—Sera from animals with well-documented pre- and postexposure histories were used for a retrospective study to evaluate the agar gel diffusion precipitin (AGDP) test as a method of detecting antibody to VIA antigen. Sera of all but 2 of 304 animals (cattle, sheep, goats, and pigs) obtained before exposure to live virus were negative. One vaccinated and one passively immunized steer had weakly positive reactions. When non-immunized animals become infected, 80–90% had positive reactions 3–4 weeks postexposure. Some of these animals were followed for 12 weeks after infection and all continued to have either positive or weakly positive reactions. A few sheep had positive reactions for 19 months. Sera were tested from vaccinated cattle which became infected following exposure to live virus. Cattle immunized with a vaccine produced from tissue culture virus, adsorbed to aluminum hydroxide gel and inactivated with formalin, developed positive reactions following infection comparable to those of non-im-munized animals. Cattle immunized with a tissue culture virus inactivated with acetylethyleneimine and mixed with modified Freund's adjuvant had consistently weaker and shorter-lived positive reactions after infection. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a121207 |
| format | Article |
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W. (Plum Island Animal Disease Lab., U. S. Dept. of Agriculture, P.O. Box 848, Greenport, N. Y. 11944) and P. Sutmoller. Foot-and-mouth disease: The agar gel diffusion precipitin test for antibody to virus-infection-associated (VIA) antigen as a tool for epizootiologic surveys. Amer. J. Epid., 1970, 92; 273–278.—Sera from animals with well-documented pre- and postexposure histories were used for a retrospective study to evaluate the agar gel diffusion precipitin (AGDP) test as a method of detecting antibody to VIA antigen. Sera of all but 2 of 304 animals (cattle, sheep, goats, and pigs) obtained before exposure to live virus were negative. One vaccinated and one passively immunized steer had weakly positive reactions. When non-immunized animals become infected, 80–90% had positive reactions 3–4 weeks postexposure. Some of these animals were followed for 12 weeks after infection and all continued to have either positive or weakly positive reactions. 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Cattle immunized with a tissue culture virus inactivated with acetylethyleneimine and mixed with modified Freund's adjuvant had consistently weaker and shorter-lived positive reactions after infection.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a121207</identifier><identifier>PMID: 4989807</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Agar ; agar gel diffusion precipitin test ; Animals ; Antibodies - analysis ; Antibody Formation ; Antigen-Antibody Reactions ; antigens ; Cattle ; Cattle Diseases - immunology ; epizootiology ; foot-and-mouth disease ; Foot-and-Mouth Disease - immunology ; foot-and-mouth disease virus ; Goats ; Immunodiffusion ; Mice ; Retrospective Studies ; serology ; Sheep ; Sheep Diseases - immunology ; Swine ; Swine Diseases - immunology ; Viral Vaccines - therapeutic use</subject><ispartof>American journal of epidemiology, 1970-10, Vol.92 (4), p.273-278</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27869,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4989807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McVICAR, JOHN W.</creatorcontrib><creatorcontrib>SUTMOLLER, PAUL</creatorcontrib><title>FOOT-AND-MOUTH DISEASE: THE AGAR GEL DIFFUSION PRECIPITIN TEST FOR ANTIBODY TO VIRUS-INFECTION-ASSOCIATED (VIA) ANTIGEN AS A TOOL FOR EPIZOOTIOLOGIC SURVEYS</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>McVicar, J. W. (Plum Island Animal Disease Lab., U. S. Dept. of Agriculture, P.O. Box 848, Greenport, N. Y. 11944) and P. Sutmoller. Foot-and-mouth disease: The agar gel diffusion precipitin test for antibody to virus-infection-associated (VIA) antigen as a tool for epizootiologic surveys. Amer. J. Epid., 1970, 92; 273–278.—Sera from animals with well-documented pre- and postexposure histories were used for a retrospective study to evaluate the agar gel diffusion precipitin (AGDP) test as a method of detecting antibody to VIA antigen. Sera of all but 2 of 304 animals (cattle, sheep, goats, and pigs) obtained before exposure to live virus were negative. One vaccinated and one passively immunized steer had weakly positive reactions. When non-immunized animals become infected, 80–90% had positive reactions 3–4 weeks postexposure. Some of these animals were followed for 12 weeks after infection and all continued to have either positive or weakly positive reactions. A few sheep had positive reactions for 19 months. Sera were tested from vaccinated cattle which became infected following exposure to live virus. Cattle immunized with a vaccine produced from tissue culture virus, adsorbed to aluminum hydroxide gel and inactivated with formalin, developed positive reactions following infection comparable to those of non-im-munized animals. Cattle immunized with a tissue culture virus inactivated with acetylethyleneimine and mixed with modified Freund's adjuvant had consistently weaker and shorter-lived positive reactions after infection.</description><subject>Agar</subject><subject>agar gel diffusion precipitin test</subject><subject>Animals</subject><subject>Antibodies - analysis</subject><subject>Antibody Formation</subject><subject>Antigen-Antibody Reactions</subject><subject>antigens</subject><subject>Cattle</subject><subject>Cattle Diseases - immunology</subject><subject>epizootiology</subject><subject>foot-and-mouth disease</subject><subject>Foot-and-Mouth Disease - immunology</subject><subject>foot-and-mouth disease virus</subject><subject>Goats</subject><subject>Immunodiffusion</subject><subject>Mice</subject><subject>Retrospective Studies</subject><subject>serology</subject><subject>Sheep</subject><subject>Sheep Diseases - immunology</subject><subject>Swine</subject><subject>Swine Diseases - immunology</subject><subject>Viral Vaccines - 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W. (Plum Island Animal Disease Lab., U. S. Dept. of Agriculture, P.O. Box 848, Greenport, N. Y. 11944) and P. Sutmoller. Foot-and-mouth disease: The agar gel diffusion precipitin test for antibody to virus-infection-associated (VIA) antigen as a tool for epizootiologic surveys. Amer. J. Epid., 1970, 92; 273–278.—Sera from animals with well-documented pre- and postexposure histories were used for a retrospective study to evaluate the agar gel diffusion precipitin (AGDP) test as a method of detecting antibody to VIA antigen. Sera of all but 2 of 304 animals (cattle, sheep, goats, and pigs) obtained before exposure to live virus were negative. One vaccinated and one passively immunized steer had weakly positive reactions. When non-immunized animals become infected, 80–90% had positive reactions 3–4 weeks postexposure. Some of these animals were followed for 12 weeks after infection and all continued to have either positive or weakly positive reactions. A few sheep had positive reactions for 19 months. Sera were tested from vaccinated cattle which became infected following exposure to live virus. Cattle immunized with a vaccine produced from tissue culture virus, adsorbed to aluminum hydroxide gel and inactivated with formalin, developed positive reactions following infection comparable to those of non-im-munized animals. Cattle immunized with a tissue culture virus inactivated with acetylethyleneimine and mixed with modified Freund's adjuvant had consistently weaker and shorter-lived positive reactions after infection.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>4989807</pmid><doi>10.1093/oxfordjournals.aje.a121207</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | American journal of epidemiology, 1970-10, Vol.92 (4), p.273-278 |
| issn | 0002-9262 1476-6256 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84743176 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Periodicals Index Online |
| subjects | Agar agar gel diffusion precipitin test Animals Antibodies - analysis Antibody Formation Antigen-Antibody Reactions antigens Cattle Cattle Diseases - immunology epizootiology foot-and-mouth disease Foot-and-Mouth Disease - immunology foot-and-mouth disease virus Goats Immunodiffusion Mice Retrospective Studies serology Sheep Sheep Diseases - immunology Swine Swine Diseases - immunology Viral Vaccines - therapeutic use |
| title | FOOT-AND-MOUTH DISEASE: THE AGAR GEL DIFFUSION PRECIPITIN TEST FOR ANTIBODY TO VIRUS-INFECTION-ASSOCIATED (VIA) ANTIGEN AS A TOOL FOR EPIZOOTIOLOGIC SURVEYS |
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