Uptake of probenecid by rat liver slices

The uptake of 14C-probenecid by rat liver has been studied by standard tissue-slice methods. No metabolites of this transport inhibitor accumulated in the slices, but the.parent drug and a single metabolite appeared in the incubation media. The metabolite was identified by GLC-MS procedures as the g...

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Veröffentlicht in:	Biochemical pharmacology 1970-09, Vol.19 (9), p.2653-2662
Hauptverfasser:	Gigon, Philippe L., Guarino, Anthony M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport, Active - drug effects Carbon Isotopes Chlorothiazide - pharmacology Chromatography, Gas Cyanides - pharmacology Filtration Glucuronates - analysis Imides - pharmacology In Vitro Techniques Iodoacetates - pharmacology Iopanoic Acid - pharmacology Liver - drug effects Liver - metabolism Male Maleates - pharmacology NAD - pharmacology Phlorhizin - pharmacology Probenecid - metabolism Procainamide - pharmacology Protein Binding - drug effects Rats Sodium - pharmacology Sulfobromophthalein - pharmacology Triazines - pharmacology Ultracentrifugation
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