Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

Endothelial dysfunction is a hallmark of, and plays a pivotal role in the pathogenesis of cardiometabolic diseases, including type II diabetes, obesity, and hypertension. It has been well established that epoxyeicosatrienoic acids (EETs) act as an endothelial derived hyperpolarization factor (EDHF)....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2011-03, Vol.654 (1), p.68-74
Hauptverfasser:	Zhang, Le-Ning, Vincelette, Jon, Chen, Dawn, Gless, Richard D., Anandan, Sampath-Kumar, Rubanyi, Gabor M., Webb, Heather K., MacIntyre, D. Euan, Wang, Yi-Xin (Jim)
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Adamantane - administration & dosage Adamantane - analogs & derivatives Adamantane - pharmacology Administration, Oral animal models Animals aorta Aorta - drug effects Aorta - metabolism Arterial hypertension. Arterial hypotension bioactive properties Biological and medical sciences blood Blood and lymphatic vessels Cardiology. Vascular system Cardiometabolic diseases Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelial derived hyperpolarization factors Endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - pathology epoxide hydrolase Epoxide Hydrolases - antagonists & inhibitors Epoxide Hydrolases - metabolism epoxides Epoxyeicosatrienoic acids Etiopathogenesis. Screening. Investigations. Target tissue resistance hypertension Hypertension - drug therapy Hypertension - physiopathology indomethacin Male Medical sciences mesenteric arteries Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Metabolic diseases Mice Mice, Inbred C57BL Niacinamide - administration & dosage Niacinamide - analogs & derivatives Niacinamide - pharmacology nitric oxide nitroprusside noninsulin-dependent diabetes mellitus Obesity Obesity - drug therapy Obesity - physiopathology oral administration pathogenesis Pharmacology. Drug treatments phenylephrine Phenylurea Compounds - administration & dosage Phenylurea Compounds - pharmacology prostacyclin prostaglandin synthase Rats Rats, Sprague-Dawley Soluble epoxide hydrolase Urea - administration & dosage Urea - analogs & derivatives Urea - pharmacology vasodilation Vasodilation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!