Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D₂ receptor antagonist

Compound 21 (AM432) was identified as a potent and selective antagonist of the DP₂ receptor (CRTH2). Modification of a bi-aryl core identified a series of tri-aryl antagonists of which compound 21 proved a viable clinical candidate. AM432 shows excellent potency in a human whole blood eosinophil sha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-02, Vol.21 (3), p.1036-1040
Hauptverfasser:	Stock, Nicholas, Volkots, Deborah, Stebbins, Karin, Broadhead, Alex, Stearns, Brian, Roppe, Jeffrey, Parr, Timothy, Baccei, Christopher, Bain, Gretchen, Chapman, Charles, Correa, Lucia, Darlington, Janice, King, Christopher, Lee, Catherine, Lorrain, Daniel S, Prodanovich, Pat, Santini, Angelina, Evans, Jilly F, Hutchinson, John H, Prasit, Peppi
Format:	Artikel
Sprache:	eng
Schlagworte:	acetates Administration, Oral animal models Animals antagonists Biological and medical sciences blood Bones, joints and connective tissue. Antiinflammatory agents Disease Models, Animal Dogs Eosinophils - drug effects Eosinophils - immunology Humans Immunomodulators Inflammation - drug therapy Medical sciences Mice pharmacokinetics Pharmacology. Drug treatments Phenylacetates - chemistry Phenylacetates - pharmacokinetics Phenylacetates - therapeutic use prostaglandins Pyridines - chemistry Pyridines - pharmacokinetics Pyridines - therapeutic use Receptors, Immunologic - antagonists & inhibitors Receptors, Immunologic - metabolism Receptors, Prostaglandin - antagonists & inhibitors Receptors, Prostaglandin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!