Characterization of Diverse Subvariants of the Meningococcal Factor H (fH) Binding Protein for Their Ability To Bind fH, To Mediate Serum Resistance, and To Induce Bactericidal Antibodies

Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds human factor H (fH), enabling downregulation of complement activation on the bacterial surface. fHbp is a component of two se...

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Veröffentlicht in:	Infection and Immunity 2011-02, Vol.79 (2), p.970-981
Hauptverfasser:	Seib, Kate L, Brunelli, Brunella, Brogioni, Barbara, Palumbo, Emmanuelle, Bambini, Stefania, Muzzi, Alessandro, DiMarcello, Federica, Marchi, Sara, van der Ende, Arie, Aricó, Beatrice, Savino, Silvana, Scarselli, Maria, Comanducci, Maurizio, Rappuoli, Rino, Giuliani, Marzia M, Pizza, Mariagrazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Bacterial - metabolism Bacteria Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Complement Factor H - metabolism Complement System Proteins Female Fundamental and applied biological sciences. Psychology Genetic Variation Humans Meningococcal Infections - immunology Meningococcal Infections - microbiology Mice Microbial Immunity and Vaccines Microbiology Miscellaneous Molecular Sequence Data Neisseria meningitidis Neisseria meningitidis - genetics Neisseria meningitidis - metabolism Phylogeny Protein Binding Rabbits
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