APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans
The mechanism that regulates the terminal maturation of hematopoietic stem cells into erythroid cells is poorly understood. Therefore, identifying genes and surface markers that are restricted to specific stages of erythroid maturation will further our understanding of erythropoiesis. To identify ge...
Gespeichert in:
| Veröffentlicht in: | Stem cell reviews 2011-03, Vol.7 (1), p.43-52 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 52 |
|---|---|
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Stem cell reviews |
| container_volume | 7 |
| creator | Inoue, Tomoko Sugiyama, Daisuke Kurita, Ryo Oikawa, Tatsuo Kulkeaw, Kasem Kawano, Hirotaka Miura, Yoshie Okada, Michiyo Suehiro, Youko Takahashi, Atsushi Marumoto, Tomotoshi Inoue, Hiroyuki Komatsu, Norio Tani, Kenzaburo |
| description | The mechanism that regulates the terminal maturation of hematopoietic stem cells into erythroid cells is poorly understood. Therefore, identifying genes and surface markers that are restricted to specific stages of erythroid maturation will further our understanding of erythropoiesis. To identify genes expressed at discrete stages of erythroid development, we screened for genes that contributed to the proliferation and maturation of erythropoietin (EPO)-dependent UT-7/EPO cells. After transducing erythroid cells with a human fetal liver (FL)-derived lentiviral cDNA library and culturing the cells in the absence of EPO, we identified 17 candidate genes that supported erythroid colony formation. In addition, the mouse homologues of these candidate genes were identified and their expression was examined in E12.5 erythroid populations by qRT-PCR. The expression of candidate erythroid marker was also assessed at the protein level by immunohistochemistry and ELISA. Our study demonstrated that expression of the
Apoa-1
gene, an apolipoprotein family member, significantly increased as hematopoietic stem cells differentiated into mature erythroid cells in the mouse FL. The Apoa-1 protein was more abundant in mature erythroid cells than hematopoietic stem and progenitor cells in the mouse FL by ELISA. Moreover,
APOA-1
gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans. |
| doi_str_mv | 10.1007/s12015-010-9140-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_847281917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>847281917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-a8ed32e787b4486135a43656157e45119db0603d24686d73fdad6ddb97455d163</originalsourceid><addsrcrecordid>eNp9kc1uEzEURi0EIqHwAGyQxYZu3PqO_5dRVBqklFYC1pYz9oBDZhzsGaS-fZ2mUKkSrGzpHn_-rg5Cb4GeAaXqvEBDQRAKlBjglKhnaA5CaCI15c_v75Row9kMvSplSynTXMNLNGsoU1IoNUfd4uZ6QQDHgh3-nH6HHb5y-WfIOHX4It-OP3KKHi_D7jAYp-zGmAbc5dTjVejdmPYphjG2-MsY-nuu4Djgq9gG7AaPV1PvhvIavejcroQ3D-cJ-vbx4utyRdbXl5-WizVpuTQjcTp41gSl1YZzLYEJx5kUEoQKXAAYv6GSMt9wqaVXrPPOS-83RnEhPEh2gj4cc_c5_ZpCGW0fS1tLuSGkqVjNVaPBgKrk6X9JoIbxWsKwir5_gm7TlIe6h9VCGgmy0RWCI9TmVEoOnd3n2Lt8W5PswZY92rLVlj3YsocO7x6Cp00f_N8Xf_RUoDkCpY6G7yE__vzv1Dt-JJwC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>856961628</pqid></control><display><type>article</type><title>APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Inoue, Tomoko ; Sugiyama, Daisuke ; Kurita, Ryo ; Oikawa, Tatsuo ; Kulkeaw, Kasem ; Kawano, Hirotaka ; Miura, Yoshie ; Okada, Michiyo ; Suehiro, Youko ; Takahashi, Atsushi ; Marumoto, Tomotoshi ; Inoue, Hiroyuki ; Komatsu, Norio ; Tani, Kenzaburo</creator><creatorcontrib>Inoue, Tomoko ; Sugiyama, Daisuke ; Kurita, Ryo ; Oikawa, Tatsuo ; Kulkeaw, Kasem ; Kawano, Hirotaka ; Miura, Yoshie ; Okada, Michiyo ; Suehiro, Youko ; Takahashi, Atsushi ; Marumoto, Tomotoshi ; Inoue, Hiroyuki ; Komatsu, Norio ; Tani, Kenzaburo</creatorcontrib><description>The mechanism that regulates the terminal maturation of hematopoietic stem cells into erythroid cells is poorly understood. Therefore, identifying genes and surface markers that are restricted to specific stages of erythroid maturation will further our understanding of erythropoiesis. To identify genes expressed at discrete stages of erythroid development, we screened for genes that contributed to the proliferation and maturation of erythropoietin (EPO)-dependent UT-7/EPO cells. After transducing erythroid cells with a human fetal liver (FL)-derived lentiviral cDNA library and culturing the cells in the absence of EPO, we identified 17 candidate genes that supported erythroid colony formation. In addition, the mouse homologues of these candidate genes were identified and their expression was examined in E12.5 erythroid populations by qRT-PCR. The expression of candidate erythroid marker was also assessed at the protein level by immunohistochemistry and ELISA. Our study demonstrated that expression of the
Apoa-1
gene, an apolipoprotein family member, significantly increased as hematopoietic stem cells differentiated into mature erythroid cells in the mouse FL. The Apoa-1 protein was more abundant in mature erythroid cells than hematopoietic stem and progenitor cells in the mouse FL by ELISA. Moreover,
APOA-1
gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans.</description><identifier>ISSN: 1550-8943</identifier><identifier>ISSN: 2629-3269</identifier><identifier>EISSN: 1558-6804</identifier><identifier>EISSN: 2629-3277</identifier><identifier>DOI: 10.1007/s12015-010-9140-7</identifier><identifier>PMID: 20376577</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Animals ; Apolipoprotein A-I - genetics ; Apolipoprotein A-I - metabolism ; Apolipoproteins ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Cell Biology ; Cell Differentiation ; Cell Line ; Cell Proliferation ; Cell Separation ; Erythroid Cells - cytology ; Erythroid Cells - metabolism ; Erythropoietin - metabolism ; Fetus - metabolism ; Gene Expression Regulation, Developmental ; Gene Library ; Genetic Association Studies ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - metabolism ; Humans ; Lentivirus - genetics ; Life Sciences ; Liver - cytology ; Liver - metabolism ; Mice ; Receptors, Erythropoietin - metabolism ; Regenerative Medicine/Tissue Engineering ; Signal Transduction ; Stem Cells ; Transduction, Genetic</subject><ispartof>Stem cell reviews, 2011-03, Vol.7 (1), p.43-52</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-a8ed32e787b4486135a43656157e45119db0603d24686d73fdad6ddb97455d163</citedby><cites>FETCH-LOGICAL-c469t-a8ed32e787b4486135a43656157e45119db0603d24686d73fdad6ddb97455d163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20376577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Tomoko</creatorcontrib><creatorcontrib>Sugiyama, Daisuke</creatorcontrib><creatorcontrib>Kurita, Ryo</creatorcontrib><creatorcontrib>Oikawa, Tatsuo</creatorcontrib><creatorcontrib>Kulkeaw, Kasem</creatorcontrib><creatorcontrib>Kawano, Hirotaka</creatorcontrib><creatorcontrib>Miura, Yoshie</creatorcontrib><creatorcontrib>Okada, Michiyo</creatorcontrib><creatorcontrib>Suehiro, Youko</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Marumoto, Tomotoshi</creatorcontrib><creatorcontrib>Inoue, Hiroyuki</creatorcontrib><creatorcontrib>Komatsu, Norio</creatorcontrib><creatorcontrib>Tani, Kenzaburo</creatorcontrib><title>APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans</title><title>Stem cell reviews</title><addtitle>Stem Cell Rev and Rep</addtitle><addtitle>Stem Cell Rev Rep</addtitle><description>The mechanism that regulates the terminal maturation of hematopoietic stem cells into erythroid cells is poorly understood. Therefore, identifying genes and surface markers that are restricted to specific stages of erythroid maturation will further our understanding of erythropoiesis. To identify genes expressed at discrete stages of erythroid development, we screened for genes that contributed to the proliferation and maturation of erythropoietin (EPO)-dependent UT-7/EPO cells. After transducing erythroid cells with a human fetal liver (FL)-derived lentiviral cDNA library and culturing the cells in the absence of EPO, we identified 17 candidate genes that supported erythroid colony formation. In addition, the mouse homologues of these candidate genes were identified and their expression was examined in E12.5 erythroid populations by qRT-PCR. The expression of candidate erythroid marker was also assessed at the protein level by immunohistochemistry and ELISA. Our study demonstrated that expression of the
Apoa-1
gene, an apolipoprotein family member, significantly increased as hematopoietic stem cells differentiated into mature erythroid cells in the mouse FL. The Apoa-1 protein was more abundant in mature erythroid cells than hematopoietic stem and progenitor cells in the mouse FL by ELISA. Moreover,
APOA-1
gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans.</description><subject>Animals</subject><subject>Apolipoprotein A-I - genetics</subject><subject>Apolipoprotein A-I - metabolism</subject><subject>Apolipoproteins</subject><subject>Biomarkers - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Cell Separation</subject><subject>Erythroid Cells - cytology</subject><subject>Erythroid Cells - metabolism</subject><subject>Erythropoietin - metabolism</subject><subject>Fetus - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Library</subject><subject>Genetic Association Studies</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Humans</subject><subject>Lentivirus - genetics</subject><subject>Life Sciences</subject><subject>Liver - cytology</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Receptors, Erythropoietin - metabolism</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Signal Transduction</subject><subject>Stem Cells</subject><subject>Transduction, Genetic</subject><issn>1550-8943</issn><issn>2629-3269</issn><issn>1558-6804</issn><issn>2629-3277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1uEzEURi0EIqHwAGyQxYZu3PqO_5dRVBqklFYC1pYz9oBDZhzsGaS-fZ2mUKkSrGzpHn_-rg5Cb4GeAaXqvEBDQRAKlBjglKhnaA5CaCI15c_v75Row9kMvSplSynTXMNLNGsoU1IoNUfd4uZ6QQDHgh3-nH6HHb5y-WfIOHX4It-OP3KKHi_D7jAYp-zGmAbc5dTjVejdmPYphjG2-MsY-nuu4Djgq9gG7AaPV1PvhvIavejcroQ3D-cJ-vbx4utyRdbXl5-WizVpuTQjcTp41gSl1YZzLYEJx5kUEoQKXAAYv6GSMt9wqaVXrPPOS-83RnEhPEh2gj4cc_c5_ZpCGW0fS1tLuSGkqVjNVaPBgKrk6X9JoIbxWsKwir5_gm7TlIe6h9VCGgmy0RWCI9TmVEoOnd3n2Lt8W5PswZY92rLVlj3YsocO7x6Cp00f_N8Xf_RUoDkCpY6G7yE__vzv1Dt-JJwC</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Inoue, Tomoko</creator><creator>Sugiyama, Daisuke</creator><creator>Kurita, Ryo</creator><creator>Oikawa, Tatsuo</creator><creator>Kulkeaw, Kasem</creator><creator>Kawano, Hirotaka</creator><creator>Miura, Yoshie</creator><creator>Okada, Michiyo</creator><creator>Suehiro, Youko</creator><creator>Takahashi, Atsushi</creator><creator>Marumoto, Tomotoshi</creator><creator>Inoue, Hiroyuki</creator><creator>Komatsu, Norio</creator><creator>Tani, Kenzaburo</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans</title><author>Inoue, Tomoko ; Sugiyama, Daisuke ; Kurita, Ryo ; Oikawa, Tatsuo ; Kulkeaw, Kasem ; Kawano, Hirotaka ; Miura, Yoshie ; Okada, Michiyo ; Suehiro, Youko ; Takahashi, Atsushi ; Marumoto, Tomotoshi ; Inoue, Hiroyuki ; Komatsu, Norio ; Tani, Kenzaburo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-a8ed32e787b4486135a43656157e45119db0603d24686d73fdad6ddb97455d163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Apolipoprotein A-I - genetics</topic><topic>Apolipoprotein A-I - metabolism</topic><topic>Apolipoproteins</topic><topic>Biomarkers - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Cell Line</topic><topic>Cell Proliferation</topic><topic>Cell Separation</topic><topic>Erythroid Cells - cytology</topic><topic>Erythroid Cells - metabolism</topic><topic>Erythropoietin - metabolism</topic><topic>Fetus - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Library</topic><topic>Genetic Association Studies</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Humans</topic><topic>Lentivirus - genetics</topic><topic>Life Sciences</topic><topic>Liver - cytology</topic><topic>Liver - metabolism</topic><topic>Mice</topic><topic>Receptors, Erythropoietin - metabolism</topic><topic>Regenerative Medicine/Tissue Engineering</topic><topic>Signal Transduction</topic><topic>Stem Cells</topic><topic>Transduction, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Tomoko</creatorcontrib><creatorcontrib>Sugiyama, Daisuke</creatorcontrib><creatorcontrib>Kurita, Ryo</creatorcontrib><creatorcontrib>Oikawa, Tatsuo</creatorcontrib><creatorcontrib>Kulkeaw, Kasem</creatorcontrib><creatorcontrib>Kawano, Hirotaka</creatorcontrib><creatorcontrib>Miura, Yoshie</creatorcontrib><creatorcontrib>Okada, Michiyo</creatorcontrib><creatorcontrib>Suehiro, Youko</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Marumoto, Tomotoshi</creatorcontrib><creatorcontrib>Inoue, Hiroyuki</creatorcontrib><creatorcontrib>Komatsu, Norio</creatorcontrib><creatorcontrib>Tani, Kenzaburo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Stem cell reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Tomoko</au><au>Sugiyama, Daisuke</au><au>Kurita, Ryo</au><au>Oikawa, Tatsuo</au><au>Kulkeaw, Kasem</au><au>Kawano, Hirotaka</au><au>Miura, Yoshie</au><au>Okada, Michiyo</au><au>Suehiro, Youko</au><au>Takahashi, Atsushi</au><au>Marumoto, Tomotoshi</au><au>Inoue, Hiroyuki</au><au>Komatsu, Norio</au><au>Tani, Kenzaburo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans</atitle><jtitle>Stem cell reviews</jtitle><stitle>Stem Cell Rev and Rep</stitle><addtitle>Stem Cell Rev Rep</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>7</volume><issue>1</issue><spage>43</spage><epage>52</epage><pages>43-52</pages><issn>1550-8943</issn><issn>2629-3269</issn><eissn>1558-6804</eissn><eissn>2629-3277</eissn><abstract>The mechanism that regulates the terminal maturation of hematopoietic stem cells into erythroid cells is poorly understood. Therefore, identifying genes and surface markers that are restricted to specific stages of erythroid maturation will further our understanding of erythropoiesis. To identify genes expressed at discrete stages of erythroid development, we screened for genes that contributed to the proliferation and maturation of erythropoietin (EPO)-dependent UT-7/EPO cells. After transducing erythroid cells with a human fetal liver (FL)-derived lentiviral cDNA library and culturing the cells in the absence of EPO, we identified 17 candidate genes that supported erythroid colony formation. In addition, the mouse homologues of these candidate genes were identified and their expression was examined in E12.5 erythroid populations by qRT-PCR. The expression of candidate erythroid marker was also assessed at the protein level by immunohistochemistry and ELISA. Our study demonstrated that expression of the
Apoa-1
gene, an apolipoprotein family member, significantly increased as hematopoietic stem cells differentiated into mature erythroid cells in the mouse FL. The Apoa-1 protein was more abundant in mature erythroid cells than hematopoietic stem and progenitor cells in the mouse FL by ELISA. Moreover,
APOA-1
gene expression was detected in mature erythroid cells from human peripheral blood. We conclude that APOA-1 is a novel marker of the terminal erythroid maturation of hematopoietic stem cells in both mice and humans.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>20376577</pmid><doi>10.1007/s12015-010-9140-7</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-8943 |
| ispartof | Stem cell reviews, 2011-03, Vol.7 (1), p.43-52 |
| issn | 1550-8943 2629-3269 1558-6804 2629-3277 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_847281917 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Apolipoprotein A-I - genetics Apolipoprotein A-I - metabolism Apolipoproteins Biomarkers - metabolism Biomedical and Life Sciences Biomedical Engineering and Bioengineering Cell Biology Cell Differentiation Cell Line Cell Proliferation Cell Separation Erythroid Cells - cytology Erythroid Cells - metabolism Erythropoietin - metabolism Fetus - metabolism Gene Expression Regulation, Developmental Gene Library Genetic Association Studies Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Lentivirus - genetics Life Sciences Liver - cytology Liver - metabolism Mice Receptors, Erythropoietin - metabolism Regenerative Medicine/Tissue Engineering Signal Transduction Stem Cells Transduction, Genetic |
| title | APOA-1 is a Novel Marker of Erythroid Cell Maturation from Hematopoietic Stem Cells in Mice and Humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T19%3A53%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=APOA-1%20is%20a%20Novel%20Marker%20of%20Erythroid%20Cell%20Maturation%20from%20Hematopoietic%20Stem%20Cells%20in%20Mice%20and%20Humans&rft.jtitle=Stem%20cell%20reviews&rft.au=Inoue,%20Tomoko&rft.date=2011-03-01&rft.volume=7&rft.issue=1&rft.spage=43&rft.epage=52&rft.pages=43-52&rft.issn=1550-8943&rft.eissn=1558-6804&rft_id=info:doi/10.1007/s12015-010-9140-7&rft_dat=%3Cproquest_cross%3E847281917%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=856961628&rft_id=info:pmid/20376577&rfr_iscdi=true |