Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity

Defective mismatch repair leads to the microsatellite instability (MSI) phenotype of colorectal cancer (CRC). We previously showed that the MLH1-93G>A promoter polymorphism is strongly associated with MSI tumours, suggesting a modifier role for this polymorphism in CRC. The MLH1 promoter is bi-di...

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Veröffentlicht in:	Oncology reports 2011-03, Vol.25 (3), p.809-815
Hauptverfasser:	PERERA, Sheron, MRKONJIC, Miralem, RAWSON, James B, BAPAT, Bharati
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Biological and medical sciences Carcinoma - genetics Carrier Proteins - genetics Carrier Proteins - physiology Cells, Cultured Colorectal Neoplasms - genetics Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic HCT116 Cells HT29 Cells Humans Medical sciences Microsatellite Instability MutL Protein Homolog 1 Nuclear Proteins - genetics Nuclear Proteins - physiology Polymorphism, Single Nucleotide - physiology Promoter Regions, Genetic - genetics Promoter Regions, Genetic - physiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription, Genetic Transfection Tumors
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