RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor

RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell de...

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Veröffentlicht in:	Oncology reports 2011-03, Vol.25 (3), p.849-853
Hauptverfasser:	TSENG, Hsu-Hung, YU, Yung-Luen, YIANG, Giou-Teng, SOPHIA CHEN, Yi-Lin, CHEN, Jia-Hui, CHOU, Chu-Lin, KUO, Tsun-Yung, WANG, Jaang-Jiun, LEE, Ming-Chieh, HUANG, Ting-Han, CHEN, Mark Hung-Chih
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphibian Proteins - pharmacology Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Caspase 3 - metabolism Cell Death - drug effects Cell Line, Tumor Down-Regulation - drug effects Down-Regulation - genetics Drug Evaluation, Preclinical Endoribonucleases - pharmacology Female Gene Expression Regulation, Neoplastic - drug effects Genes, bcl-2 - drug effects Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Signal Transduction - drug effects Tumors
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