Pioglitazone modulates the balance of effector and regulatory T cells in apolipoprotein E deficient mice

Abstract Background and aims Pioglitazone (PIO) affects T cell-mediated immunity through actions of peroxisome proliferator activated receptor γ (PPARγ). Effector and regulatory T cells control the development of atherosclerosis, a chronic inflammatory disease affecting the arterial blood vessels. T...

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Veröffentlicht in:	Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2011-01, Vol.21 (1), p.25-32
Hauptverfasser:	Tian, Y, Yuan, Z, Liu, Y, Liu, W, Zhang, W, Xue, J, Shen, Y, Liang, X, Chen, T, Kishimoto, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apolipoprotein E Apolipoproteins E - genetics Apolipoproteins E - physiology Atherosclerosis Atherosclerosis - pathology Atherosclerosis - prevention & control blood vessels Cardiovascular cell-mediated immunity collagen Cytokines - metabolism Disease Progression Flow Cytometry Forkhead Transcription Factors - genetics Foxp3 Hypoglycemic Agents - pharmacology Immunohistochemistry Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Lipid Metabolism - drug effects Lipids - blood macrophages Mice Mice, Knockout myocytes Pioglitazone PPARγ Reverse Transcriptase Polymerase Chain Reaction RNA - genetics smooth muscle spleen Spleen - pathology T cells T-lymphocytes Th1 Cells - drug effects Th2 Cells - drug effects Thiazolidinediones - pharmacology Western diets
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