Uncoupling Action of Sulfonylureas on Brown Fat Cells

Tolbutamide markedly enhanced glucose oxidation to carbon dioxide and inhibited lactate formation by rat brown fat cells in the presence of insulin or cysteine. Tolbutamide alone increased oxygen uptake, and this stimulation was enhanced by insulin or cysteine. The effects of tolbutamide were simila...

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Veröffentlicht in:	Molecular pharmacology 1970-09, Vol.6 (5), p.513-523
Hauptverfasser:	Chan, S S, Fain, J N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Animals Carbon Dioxide - biosynthesis Carbon Isotopes Cysteine - pharmacology Female Glucose - metabolism Hypoglycemic Agents - pharmacology Insulin - pharmacology Lactates - biosynthesis Lipids - biosynthesis Oxidation-Reduction Oxygen Consumption - drug effects Phenformin - pharmacology Rabbits Rats Tolbutamide - pharmacology Triglycerides - metabolism
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