Enteroviruses associated with the hemolytic-uremic syndrome
Nine cases of the hemolytic-uremic syndrome and one case of purpura fulminans were studied clinically and virologically. All were thought to represent examples of varying degrees of intravascular coagulation. Virological studies demonstrated a high frequency of infections with enteroviruses, particu...
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| Veröffentlicht in: | Pediatrics (Evanston) 1970-09, Vol.46 (3), p.378-388 |
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| container_title | Pediatrics (Evanston) |
| container_volume | 46 |
| creator | Ray, C G Tucker, V L Harris, D J Cuppage, F E Chin, T D |
| description | Nine cases of the hemolytic-uremic syndrome and one case of purpura fulminans were studied clinically and virologically. All were thought to represent examples of varying degrees of intravascular coagulation.
Virological studies demonstrated a high frequency of infections with enteroviruses, particularly Coxsackie viruses. Evidence of such infections was found in 7 of the 10 subjects, and similar viral Infections were found among family contacts of 5 of the subjects.
Studies of the various subjects and the available family contacts demonstrated evidence of having recent enteroviral infection in the patient and/or the immediate family in 9 of the 10 subjects studied.
It is suggested that enteroviruses may have a role in initiating the sequence of events involved in the pathogenesis of these illnesses. |
| doi_str_mv | 10.1542/peds.46.3.378 |
| format | Article |
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Virological studies demonstrated a high frequency of infections with enteroviruses, particularly Coxsackie viruses. Evidence of such infections was found in 7 of the 10 subjects, and similar viral Infections were found among family contacts of 5 of the subjects.
Studies of the various subjects and the available family contacts demonstrated evidence of having recent enteroviral infection in the patient and/or the immediate family in 9 of the 10 subjects studied.
It is suggested that enteroviruses may have a role in initiating the sequence of events involved in the pathogenesis of these illnesses.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.46.3.378</identifier><identifier>PMID: 4318342</identifier><language>eng</language><publisher>United States</publisher><subject>Acute Kidney Injury - complications ; Acute Kidney Injury - drug therapy ; Acute Kidney Injury - microbiology ; Acute Kidney Injury - pathology ; Anemia, Hemolytic - complications ; Anemia, Hemolytic - drug therapy ; Anemia, Hemolytic - microbiology ; Anemia, Hemolytic - pathology ; Antibodies ; Antigen-Antibody Reactions ; Child ; Child, Preschool ; Enterovirus ; Enterovirus B, Human ; Enterovirus Infections - genetics ; Erythrocyte Aggregation - complications ; Erythrocyte Aggregation - microbiology ; Female ; Heparin - therapeutic use ; Humans ; Immunoglobulins ; Infant ; Kidney - pathology ; Male ; Purpura - complications ; Purpura - drug therapy ; Purpura - microbiology ; Purpura - pathology ; Shwartzman Phenomenon - microbiology ; Thrombocytopenia - complications ; Thrombocytopenia - drug therapy ; Thrombocytopenia - microbiology ; Thrombocytopenia - pathology</subject><ispartof>Pediatrics (Evanston), 1970-09, Vol.46 (3), p.378-388</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c288t-47d5c1a6ee4b6a0ae58f75c854f629424e5ba640499c831d301d951cb07a588f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4318342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ray, C G</creatorcontrib><creatorcontrib>Tucker, V L</creatorcontrib><creatorcontrib>Harris, D J</creatorcontrib><creatorcontrib>Cuppage, F E</creatorcontrib><creatorcontrib>Chin, T D</creatorcontrib><title>Enteroviruses associated with the hemolytic-uremic syndrome</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Nine cases of the hemolytic-uremic syndrome and one case of purpura fulminans were studied clinically and virologically. All were thought to represent examples of varying degrees of intravascular coagulation.
Virological studies demonstrated a high frequency of infections with enteroviruses, particularly Coxsackie viruses. Evidence of such infections was found in 7 of the 10 subjects, and similar viral Infections were found among family contacts of 5 of the subjects.
Studies of the various subjects and the available family contacts demonstrated evidence of having recent enteroviral infection in the patient and/or the immediate family in 9 of the 10 subjects studied.
It is suggested that enteroviruses may have a role in initiating the sequence of events involved in the pathogenesis of these illnesses.</description><subject>Acute Kidney Injury - complications</subject><subject>Acute Kidney Injury - drug therapy</subject><subject>Acute Kidney Injury - microbiology</subject><subject>Acute Kidney Injury - pathology</subject><subject>Anemia, Hemolytic - complications</subject><subject>Anemia, Hemolytic - drug therapy</subject><subject>Anemia, Hemolytic - microbiology</subject><subject>Anemia, Hemolytic - pathology</subject><subject>Antibodies</subject><subject>Antigen-Antibody Reactions</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Enterovirus</subject><subject>Enterovirus B, Human</subject><subject>Enterovirus Infections - genetics</subject><subject>Erythrocyte Aggregation - complications</subject><subject>Erythrocyte Aggregation - microbiology</subject><subject>Female</subject><subject>Heparin - therapeutic use</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Purpura - complications</subject><subject>Purpura - drug therapy</subject><subject>Purpura - microbiology</subject><subject>Purpura - pathology</subject><subject>Shwartzman Phenomenon - microbiology</subject><subject>Thrombocytopenia - complications</subject><subject>Thrombocytopenia - drug therapy</subject><subject>Thrombocytopenia - microbiology</subject><subject>Thrombocytopenia - pathology</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LwzAYh4Moc06PHoWevLXm402b4knG_ICBFz2HNH3LIu0yk1TZf2_Hhqff5eGB30PILaMFk8AfdtjGAspCFKJSZ2TOaK1y4JU8J3NKBcuBUnlJrmL8opSCrPiMzEAwJYDPyeNqmzD4HxfGiDEzMXrrTMI2-3Vpk6UNZhscfL9PzuZjwMHZLO63bfADXpOLzvQRb067IJ_Pq4_la75-f3lbPq1zy5VKOVSttMyUiNCUhhqUqqukVRK6ktfAAWVjSqBQ11YJ1grK2loy29DKSKU6sSD3R-8u-O8RY9KDixb73mzRj1ErqKbPSk1gfgRt8DEG7PQuuMGEvWZUH2LpQywNpRZ6ijXxdyfx2AzY_tOnOuIPgC9l3w</recordid><startdate>197009</startdate><enddate>197009</enddate><creator>Ray, C G</creator><creator>Tucker, V L</creator><creator>Harris, D J</creator><creator>Cuppage, F E</creator><creator>Chin, T D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197009</creationdate><title>Enteroviruses associated with the hemolytic-uremic syndrome</title><author>Ray, C G ; Tucker, V L ; Harris, D J ; Cuppage, F E ; Chin, T D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-47d5c1a6ee4b6a0ae58f75c854f629424e5ba640499c831d301d951cb07a588f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Acute Kidney Injury - complications</topic><topic>Acute Kidney Injury - drug therapy</topic><topic>Acute Kidney Injury - microbiology</topic><topic>Acute Kidney Injury - pathology</topic><topic>Anemia, Hemolytic - complications</topic><topic>Anemia, Hemolytic - drug therapy</topic><topic>Anemia, Hemolytic - microbiology</topic><topic>Anemia, Hemolytic - pathology</topic><topic>Antibodies</topic><topic>Antigen-Antibody Reactions</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Enterovirus</topic><topic>Enterovirus B, Human</topic><topic>Enterovirus Infections - genetics</topic><topic>Erythrocyte Aggregation - complications</topic><topic>Erythrocyte Aggregation - microbiology</topic><topic>Female</topic><topic>Heparin - therapeutic use</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>Purpura - complications</topic><topic>Purpura - drug therapy</topic><topic>Purpura - microbiology</topic><topic>Purpura - pathology</topic><topic>Shwartzman Phenomenon - microbiology</topic><topic>Thrombocytopenia - complications</topic><topic>Thrombocytopenia - drug therapy</topic><topic>Thrombocytopenia - microbiology</topic><topic>Thrombocytopenia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ray, C G</creatorcontrib><creatorcontrib>Tucker, V L</creatorcontrib><creatorcontrib>Harris, D J</creatorcontrib><creatorcontrib>Cuppage, F E</creatorcontrib><creatorcontrib>Chin, T D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ray, C G</au><au>Tucker, V L</au><au>Harris, D J</au><au>Cuppage, F E</au><au>Chin, T D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enteroviruses associated with the hemolytic-uremic syndrome</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1970-09</date><risdate>1970</risdate><volume>46</volume><issue>3</issue><spage>378</spage><epage>388</epage><pages>378-388</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Nine cases of the hemolytic-uremic syndrome and one case of purpura fulminans were studied clinically and virologically. All were thought to represent examples of varying degrees of intravascular coagulation.
Virological studies demonstrated a high frequency of infections with enteroviruses, particularly Coxsackie viruses. Evidence of such infections was found in 7 of the 10 subjects, and similar viral Infections were found among family contacts of 5 of the subjects.
Studies of the various subjects and the available family contacts demonstrated evidence of having recent enteroviral infection in the patient and/or the immediate family in 9 of the 10 subjects studied.
It is suggested that enteroviruses may have a role in initiating the sequence of events involved in the pathogenesis of these illnesses.</abstract><cop>United States</cop><pmid>4318342</pmid><doi>10.1542/peds.46.3.378</doi><tpages>11</tpages></addata></record> |
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| ispartof | Pediatrics (Evanston), 1970-09, Vol.46 (3), p.378-388 |
| issn | 0031-4005 1098-4275 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acute Kidney Injury - complications Acute Kidney Injury - drug therapy Acute Kidney Injury - microbiology Acute Kidney Injury - pathology Anemia, Hemolytic - complications Anemia, Hemolytic - drug therapy Anemia, Hemolytic - microbiology Anemia, Hemolytic - pathology Antibodies Antigen-Antibody Reactions Child Child, Preschool Enterovirus Enterovirus B, Human Enterovirus Infections - genetics Erythrocyte Aggregation - complications Erythrocyte Aggregation - microbiology Female Heparin - therapeutic use Humans Immunoglobulins Infant Kidney - pathology Male Purpura - complications Purpura - drug therapy Purpura - microbiology Purpura - pathology Shwartzman Phenomenon - microbiology Thrombocytopenia - complications Thrombocytopenia - drug therapy Thrombocytopenia - microbiology Thrombocytopenia - pathology |
| title | Enteroviruses associated with the hemolytic-uremic syndrome |
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