Effect of various steroids on microsomal aliphatic hydroxylation and N-dealkylation

In rats, pretreatment for three days with spironolactone, norbelethone and ethylestrenol diminished the depth of anesthesia induced by hexobarbital, increased its aliphatic hydroxylation by liver microsomes and enhanced its elimination from blood. Similar pretreatment also enhanced the N-dealkylatio...

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Veröffentlicht in:	European journal of pharmacology 1970-04, Vol.10 (1), p.127-130
Hauptverfasser:	Solymoss, B., Varga, S., Classen, H.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Aminopyrine - metabolism Animals Drug-metabolizing Enzyme Induction - drug effects enzymes Ethylestrenol Ethylestrenol - pharmacology Female Hexobarbital - metabolism Microsomes, Liver - drug effects Norbolethone Pregnanes - pharmacology Progesterone Progesterone - pharmacology Rats Spironolactone Spironolactone - pharmacology
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