MicroRNA silencing of tumor suppressor DLC‐1 promotes efficient hepatitis C virus replication in primary human hepatocytes

MicroRNAs (miRNAs) are approximately 22‐nucleotide noncoding RNAs that constitute silencers of target gene expression. Aberrant expression of miRNA has been linked to a variety of cancers, including hepatocellular carcinoma (HCC). Hepatitis C virus (HCV) infection is considered a major cause of chro...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2011-01, Vol.53 (1), p.53-61
Hauptverfasser:	Banaudha, Krishna, Kaliszewski, Michael, Korolnek, Tamara, Florea, Liliana, Yeung, Man Lung, Jeang, Kuan‐Teh, Kumar, Ajit
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell growth Cells, Cultured Coculture Techniques Gastroenterology. Liver. Pancreas. Abdomen Gene expression GTPase-Activating Proteins - genetics Hepacivirus - physiology Hepatitis Hepatitis C Hepatitis C virus Hepatocytes - virology Hepatology Humans Infections Liver cancer Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences MicroRNAs MicroRNAs - pharmacology MicroRNAs - physiology Proteins RNA Interference - physiology Tumor Suppressor Proteins - genetics Virus Replication - drug effects Virus Replication - genetics
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